scholarly journals Evaluation of the Switch From Amiodarone to Dronedarone in Patients With Atrial Fibrillation: Results of the ARTEMIS AF Studies

2020 ◽  
Vol 25 (5) ◽  
pp. 425-437
Author(s):  
Gerald V. Naccarelli ◽  
Deepak L. Bhatt ◽  
A. John Camm ◽  
Jean-Yves Le Heuzey ◽  
Federico Lombardi ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Antiarrhythmic Drugs ◽  
Adverse Reactions ◽  
Optimal Timing ◽  
Atrial Fibrillation Recurrence ◽  
Term Study ◽  
Long Term Study ◽  
Poor Recruitment ◽  
Long Term Studies

Background: Switching between antiarrhythmic drugs is timed to minimize arrhythmia recurrence and adverse reactions. Dronedarone and amiodarone have similar electrophysiological profiles; however, little is known about the optimal timing of switching, given the long half-life of amiodarone. Methods: The ARTEMIS atrial fibrillation (AF) Loading and Long-term studies evaluated switching patients with paroxysmal/persistent AF from amiodarone to dronedarone. Patients were randomized based on the timing of the switch: immediate, after a 2-week, or after a 4-week washout of amiodarone. Patients who did not convert to sinus rhythm after amiodarone loading underwent electrical cardioversion. The primary objectives were, for the Loading study, to evaluate recurrence of AF ≤60 days; and for the Long-term study, to profile the pharmacokinetics of dronedarone and its metabolite according to different timings of dronedarone initiation. Results: In ARTEMIS AF Loading, 176 were randomized (planned 768) after a 28 ± 2 days load of oral amiodarone. Atrial fibrillation recurrence trended less in the immediate switch versus 4-week washout group (hazard ratio [HR] = 0.65 [97.5% CI: 0.34-1.23]; P = .14) and in the 2-week washout versus the 4-week washout group (HR = 0.75 [97.5% CI: 0.41-1.37]; P = .32). In ARTEMIS AF Long-term, 108 patients were randomized (planned 105). Pharmacokinetic analyses (n = 97) showed no significant differences for dronedarone/SR35021 exposures in the 3 groups. Conclusion: The trial was terminated early due to poor recruitment and so our findings are limited by low numbers. However, immediate switching from amiodarone to dronedarone appeared to be well tolerated and safe.

scholarly journals Climatic Factors, Reproductive Success and Population Dynamics in the Montane Vole, Microtus montanus

1997 ◽  
Vol 21 ◽  
pp. 57-59
Author(s):  
Aelita Pinter
Keyword(s):  
Population Dynamics ◽  
Population Density ◽  
National Park ◽  
Climatic Factors ◽  
Term Study ◽  
Microtus Montanus ◽  
Long Term Study ◽  
Small Measure ◽  
Long Term Studies

Multiannual fluctuations ("cycles") in population density of small rodents doubtless result from the interaction of a multitude of factors, as evidenced by the variety of hypotheses proposed to explain the phenomenon (for reviews see Finerty 1980, Taitt and Krebs 1985). However, the inability of these hypotheses - alone or in combination - to explain the causality of cycles rests in no small measure with the fact that long-term studies of the phenomenon are notoriously uncommon. The objectives of this project are to continue a long-term study of the population dynamics of the montane vole, Microtus montanus, in Grand Teton National Park. On the basis of earlier observations (Pinter 1986, 1988) particular emphasis will be placed on how environmental variables, possibly acting through reproductive responses, contribute to the population density cycles of these rodents.

scholarly journals Climatic Factors, Reproductive Success and Population Dynamics in the Montane Vole, Microtus montanus.

2003 ◽  
Vol 27 ◽  
pp. 42-44
Author(s):  
Aelita Pinter
Keyword(s):  
Population Dynamics ◽  
Population Density ◽  
National Park ◽  
Climatic Factors ◽  
Term Study ◽  
Microtus Montanus ◽  
Long Term Study ◽  
Small Measure ◽  
Long Term Studies

A variety of hypotheses have been proposed to explain multiannual fluctuations in population density ("cycles") of small rodents (for reviews see Finerty 1980, Taitt and Krebs 1985). Doubtless, such cycles - known since antiquity (Elton 1942) - result from an interaction of a multitude of factors. However, the inability of extant hypotheses, alone or in combination, to explain the causality of cycles rests in no small measure with the fact that long-term studies of the phenomenon are notoriously uncommon. The objectives of this project are to continue the long-term study of population dynamics of the montane vole, Microtus montanus, in Grand Teton National Park. Earlier observations (Pinter 1986, 1988) indicate that environmental variables might contribute to the population density cycles of these rodents, possibly by influencing their growth and various aspects of their reproduction.

scholarly journals Therapy Directed at Stretch Reduces the Frequency of Clinical Atrial Fibrillation: A Long Term Study in Patients With Mitral Stenosis

2011 ◽  
Vol 20 ◽  
pp. S87-S88
Author(s):  
B. John ◽  
J. Roshan ◽  
G. Joseph ◽  
J. Jose ◽  
O. George ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Mitral Stenosis ◽  
Term Study ◽  
Long Term Study

scholarly journals Distribution of natal dispersal distances and the genetic structure of Spruce Grouse (Falcipennis canadensis) populations

2016 ◽  
Vol 94 (6) ◽  
pp. 421-425 ◽  
Author(s):  
G.F. Barrowclough ◽  
M.A. Schroeder
Keyword(s):  
Genetic Structure ◽  
Natural Populations ◽  
Natal Dispersal ◽  
Term Study ◽  
Long Term Study ◽  
The Mean ◽  
Dispersal Distances ◽  
Breeding Seasons ◽  
Long Term Studies

Natal dispersal distances are difficult to measure, yet important for estimating the genetic structure and demographic connectedness of natural populations. Here we provide estimates of the distributions of male and female natal dispersal distances from a long-term study of Spruce Grouse (Falcipennis canadensis (L., 1758)) in southwestern Alberta, Canada, based on individuals marked as brood chicks and re-observed as adults during subsequent breeding seasons. The mean distance dispersed by females (2.33 km) was twice that of males (1.13 km), and both dispersal distributions were leptokurtic. Given estimates of population density and survivorship, we estimated the genetic effective neighborhood size of this population as approximately 541 individuals. We computed equivalent estimates for two additional long-term studies of this species, based on data available in the literature; mean natal dispersal distances, averaged across sexes, ranged from 1.73 to 2.73 km for the three populations; effective deme sizes ranged from 541 to 890. Consequently, three widespread populations of Spruce Grouse yielded roughly similar estimates of demographic and genetic structure.

scholarly journals Climatic Factors, Reproductive Success and Population Dynamics in the Montane Vole, Microtus montanus

2002 ◽  
Vol 26 ◽  
pp. 38-40
Author(s):  
Aelita Pinter
Keyword(s):  
Population Dynamics ◽  
Population Density ◽  
National Park ◽  
Climatic Factors ◽  
Term Study ◽  
Microtus Montanus ◽  
Long Term Study ◽  
Small Measure ◽  
Long Term Studies

Multiannual fluctuations ("cycles") in population density of small rodents doubtless result from the interaction of a multitude of factors, as evidenced by the variety of hypotheses proposed to explain the phenomenon (for reviews see Finerty 1980, Taitt and Krebs 1985). However, the inability of these hypotheses - alone or in combination - to explain the causality of cycles rests in no small measure with the fact that long-term studies of the phenomenon are notoriously uncommon. The objectives of this project are to continue the long-term study of the population dynamics of the montane vole, Microtus montanus, in Grand Teton National Park. On the basis of earlier observations (Pinter 1986, 1988) particular emphasis will be placed on how environmental variables, possibly acting through reproductive responses, contribute to the population density cycles of these rodents.

Variation in the milk yield, endocrine and metabolic responses following bovine somatotropin administration to dairy cows

1992 ◽  
Vol 1992 ◽  
pp. 36-36
Author(s):  
M.T. Rose ◽  
T.E.C. Weekes ◽  
P. Rowlinson
Keyword(s):  
Dairy Cows ◽  
Milk Yield ◽  
Subcutaneous Administration ◽  
Bovine Somatotropin ◽  
Yield Response ◽  
Term Study ◽  
Long Term Study ◽  
Genetic Potential ◽  
Long Term Studies

It is well established that the subcutaneous administration of bovine somatotropin (bst) to dairy cows results in an increased level of milk production. This effect occurs irrespective of the method of application, the duration of the treatment or the time after calving after which it commences. However, the reported extent of this galactopoietic effect in the published literature has been highly variable, with one long term study reporting an increase of over 11.5 kg/day (Bauman et al. 1985), whilst other long term studies have reported relatively small increases or no significant increase at all (Hof et al. 1991, Morbeck et al. 1991). As yet it is unknown what factors control the milk yield response to bst, though there is a clear effect of dose of the hormone and possibly of energy and protein balance. There are also confusing reports on the effect of the previous milk yield and genetic potential of the animal on the observed increase.

scholarly journals Natural recovery of a marine foundation species emerges decades after landscape-scale mortality

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Margaret O. Hall ◽  
Susan S. Bell ◽  
Bradley T. Furman ◽  
Michael J. Durako
Keyword(s):  
Anthropogenic Impacts ◽  
Foundation Species ◽  
Ecosystem Recovery ◽  
Term Study ◽  
Ecosystem Responses ◽  
Seagrass Community ◽  
Long Term Study ◽  
Seagrass Ecosystems ◽  
Long Term Studies

AbstractGlobally, the conditions and time scales underlying coastal ecosystem recovery following disturbance remain poorly understood, and post-disturbance examples of resilience based on long-term studies are particularly rare. Here, we documented the recovery of a marine foundation species (turtlegrass) following a hypersalinity-associated die-off in Florida Bay, USA, one of the most spatially extensive mortality events for seagrass ecosystems on record. Based upon annual sampling over two decades, foundation species recovery across the landscape was demonstrated by two ecosystem responses: the range of turtlegrass biomass met or exceeded levels present prior to the die-off, and turtlegrass regained dominance of seagrass community structure. Unlike reports for most marine taxa, recovery followed without human intervention or reduction to anthropogenic impacts. Our long-term study revealed previously uncharted resilience in subtropical seagrass landscapes but warns that future persistence of the foundation species in this iconic ecosystem will depend upon the frequency and severity of drought-associated perturbation.

scholarly journals Heroin dependence in an English town: 33-year follow-up

2005 ◽  
Vol 187 (5) ◽  
pp. 421-425 ◽  
Author(s):  
Nehkant H. Rathod ◽  
W. Mary Addenbrooke ◽  
Alan F. Rosenbach
Keyword(s):  
Small Town ◽  
Heroin Dependence ◽  
Heroin Addiction ◽  
Clinical State ◽  
Multiple Sources ◽  
Term Study ◽  
Long Term Study ◽  
Long Term Studies

BackgroundThere has been no long-term study of people addicted to injected heroin who have been treated without the prescribing of substitute opioids.AimsTo investigate the outcome for patients treated for injected heroin addiction 33 years after they were first seen, and 26 years after they were first followed up, in terms of sustained abstinence, continuing maintenance on methadone and deaths.MethodEighty-six people with heroin addiction first seen in 1966–1967 in a small town in the south-east of England were located and their clinical state assessed using multiple sources, including personal interviews with a proportion of the cohort.ResultsForty-two per cent of the cohort had been abstinent for at least 10 years; 10% were taking methadone and were classified as addicted; and 22% had died. Eight per cent of the cohort could not be located.ConclusionsResults proved favourable in the above three parameters compared with other long-term studies.

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