Dose-related periorbital edema following sorafenib in a patient with acute myeloid leukemia

2018 ◽  
Vol 25 (8) ◽  
pp. 2035-2037 ◽  
Author(s):  
Craig W Freyer ◽  
James K Mangan
Keyword(s):  
Acute Myeloid Leukemia ◽  
Adverse Event ◽  
Dose Reduction ◽  
Myeloid Leukemia ◽  
Potential Role ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Periorbital Edema ◽  
Acute Myeloid

We describe a case of dose-related periorbital edema in a patient with FLT3-mutated acute myeloid leukemia taking sorafenib and voriconazole that resolved following sorafenib dose reduction. We hypothesize that the mechanism of this adverse event may be related to the inhibition of platelet-derived growth factor receptor (PDGFR) by sorafenib. Clinicians should be aware of this possible dose-related adverse event and the potential role of sorafenib dose reduction when on concurrent voriconazole.

scholarly journals Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

Blood ◽  
2019 ◽  
Vol 134 (24) ◽  
pp. 2195-2208 ◽  
Author(s):  
Daniel Sasca ◽  
Haiyang Yun ◽  
George Giotopoulos ◽  
Jakub Szybinski ◽  
Theo Evan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Potential Role ◽  
Regulation Of Gene Expression ◽  
Specific Gene ◽  
Myeloid Malignancy ◽  
Erythroid Maturation ◽  
Acute Myeloid

Cohesin mutations are common in myeloid malignancy. Sasca et al elucidate the potential role of cohesin loss in myelodysplastic syndrome and acute myeloid leukemia (MDS/AML). They demonstrate that cohesin binding is critical for erythroid-specific gene expression and that reduction in cohesin impairs terminal erythroid maturation and promotes myeloid malignancy.

Potential role of CREB as a prognostic marker in acute myeloid leukemia

2007 ◽  
Vol 3 (4) ◽  
pp. 475-480 ◽  
Author(s):  
Jerry C Cheng ◽  
Samuel Esparza ◽  
Salemiz Sandoval ◽  
Deepa Shankar ◽  
Cecilia Fu ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Prognostic Marker ◽  
Myeloid Leukemia ◽  
Potential Role ◽  
Acute Myeloid

scholarly journals Potential role of sorafenib in the treatment of acute myeloid leukemia

2008 ◽  
Vol 49 (12) ◽  
pp. 2246-2255 ◽  
Author(s):  
Shahram Mori ◽  
Jorge Cortes ◽  
Hagop Kantarjian ◽  
Weiguo Zhang ◽  
Michael Andreef ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Potential Role ◽  
Acute Myeloid
Sign in / Sign up

Export Citation Format

Share Document