Early glycaemic control for maintaining visual function in type 1 diabetes: The Oulu cohort study of diabetic retinopathy

2018 ◽  
Vol 28 (6) ◽  
pp. 684-689 ◽  
Author(s):  
Nina Hautala ◽  
Mira Siiskonen ◽  
Virva Hannula ◽  
Kaisu Järvinen ◽  
Aura Falck
Keyword(s):  
Visual Acuity ◽  
Type 1 Diabetes ◽  
Contrast Sensitivity ◽  
Visual Function ◽  
Glycated Haemoglobin ◽  
Haemoglobin A1c ◽  
Corrected Visual Acuity ◽  
Long Duration ◽  
Haemoglobin A1

Purpose: The purpose of this study was to evaluate the visual function and the ophthalmic status of young Finnish adults with long duration of type 1 diabetes in relation to the history of the metabolic control. Methods: A population-based cohort of children with type 1 diabetes examined in the Northern Ostrobothnia hospital district in 1989 (n = 216) was re-examined 18 years later. High-contrast visual acuity (best-corrected visual acuity), contrast sensitivity, refractive error, lens status, intraocular pressure, stage of diabetic retinopathy and received treatments were evaluated. The metabolic control was reflected by the mean of glycated haemoglobin A1 or glycated haemoglobin A1c values of the years 1983–1989 and 1992–2007, respectively. Results: In all, 96 men and 76 women age 30 ± 3 years with type 1 diabetes duration of 23 ± 4 years attended the re-evaluation. About 60% (103/172) had normal best-corrected visual acuity and 3% had low vision. Contrast sensitivity was abnormal in two-thirds. Half had myopia. Four patients had cataract surgery. Low childhood glycated haemoglobin A1 was indicative, and favourable glycated haemoglobin A1c during youth was a significant predictor of better contrast sensitivity and ocular state in adulthood. Conclusion: The majority of the patients have useful vision, although minor functional impairments are commonly detectable. Long duration of type 1 diabetes in association with non-optimal glycaemic control threatens visual function already at young adulthood. Thus, strong emphasis to control diabetes from onset is important in maintaining good visual function.

scholarly journals Glycated haemoglobin variations in paediatric type 1 diabetes: the impact of season, gender and age

2013 ◽  
Vol 103 (4) ◽  
pp. 398-403 ◽  
Author(s):  
L Hanberger ◽  
K Åkesson ◽  
U Samuelsson
Keyword(s):  
Type 1 Diabetes ◽  
Glycated Haemoglobin ◽  
Gender And Age ◽  
The Impact

Self-Reported Haemoglobin A1c Highly Agrees with Laboratory-Measured Haemoglobin A1c Among Adults Living with Type 1 Diabetes: a BETTER Registry Study

2021 ◽  
pp. 101277
Author(s):  
Zekai Wu ◽  
Rémi Rabasa-Lhoret ◽  
Virginie Messier ◽  
Azadeh Shohoudi ◽  
Kaberi Dasgupta ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Haemoglobin A1c ◽  
Registry Study

scholarly journals Risk of future microvascular and macrovascular disease in people with Type 1 diabetes of very long duration: a national study with 10-year follow-up

2016 ◽  
Vol 34 (3) ◽  
pp. 411-418 ◽  
Author(s):  
S. Adamsson Eryd ◽  
A.-M. Svensson ◽  
S. Franzén ◽  
B. Eliasson ◽  
P. M. Nilsson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Macrovascular Disease ◽  
National Study ◽  
Long Duration

scholarly journals Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Marta Garcia-Contreras ◽  
Sanket H. Shah ◽  
Alejandro Tamayo ◽  
Paul D. Robbins ◽  
Ronald B. Golberg ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Long Duration

Insulin Resistance in Type 1 Diabetes of Long Duration

1986 ◽  
Vol 70 (s13) ◽  
pp. 19P-19P
Author(s):  
B.M. Singh ◽  
M. Nattrass
Keyword(s):  
Insulin Resistance ◽  
Type 1 Diabetes ◽  
Long Duration

Presence and Determinants of Cardiovascular Disease and Mortality in Individuals With Type 1 Diabetes of Long Duration: The FinnDiane 50 Years of Diabetes Study

Diabetes Care ◽  
2021 ◽  
pp. dc202816
Author(s):  
Valma Harjutsalo ◽  
Drazenka Pongrac Barlovic ◽  
Daniel Gordin ◽  
Carol Forsblom ◽  
George King ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Long Duration

scholarly journals Visual Acuity, Contrast Sensitivity and Color Vision Three Years After Iodine-125 Brachytherapy for Choroidal and Ciliary Body Melanoma

2015 ◽  
Vol 9 (1) ◽  
pp. 131-135 ◽  
Author(s):  
Irena Tsui ◽  
Robert M Beardsley ◽  
Tara A McCannel ◽  
Scott C Oliver ◽  
Melissa W Chun ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Contrast Sensitivity ◽  
Color Vision ◽  
Ciliary Body ◽  
Case Series ◽  
Vision Measurement ◽  
Corrected Visual Acuity ◽  
Iodine 125 ◽  
Decrease In Visual Acuity ◽  
Ciliary Body Melanoma

Purpose : To report visual acuity, contrast sensitivity and color vision prior to, 1 year after, 2 years after and 3 years after iodine-125 brachytherapy for choroidal and ciliary body melanoma (CCM). Design : Prospective interventional case series. Participants : Thirty-seven patients (37 eyes) with CCM. Methods : Patients had best-corrected Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity, Pelli-Robson contrast sensitivity and Hardy-Rand-Rittler color vision measurement; comprehensive ophthalmology examination; optical coherence tomography; and ultrasonography at baseline prior to, 1 year after, 2 years after and 3 years after I-125 brachytherapy. Main Outcome Measures : Visual acuity, contrast sensitivity and color vision prior to, 1 year after, 2 years after and 3 years after brachytherapy. Results : Nineteen (19) men and 18 women with mean age of 58 years (SD 13, range 30-78) prior to, 1 year after, 2 years after and 3 years after brachytherapy had mean best-corrected visual acuity of 77 letters (20/32), 65 letters (20/50), 56 letters (20/80) and 47 letters (20/125); contrast sensitivity of 30, 26, 22 and 19 letters; color vision of 26, 20, 17 and 14 test figures, respectively. Decrease in visual acuity, contrast sensitivity and color vision was statistically significant from baseline at 1 year, 2 years, and 3 years after brachytherapy. Decreased acuity at 3 years was associated with mid-choroid and macula melanoma location, ≥ 4.1 mm melanoma height, radiation maculopathy and radiation optic neuropathy. Conclusion : 1, 2 and 3 years after brachytherapy, eyes with CCM had significantly decreased visual acuity, contrast sensitivity and color vision.

Ketoacidosis in new-onset type 1 diabetes: did the severity increase during the COVID-19 pandemic?

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Teresa A. Botelho ◽  
Joana M. N. Santos ◽  
Crisbety M. S. Pinho ◽  
Ana Isabel B. R. Martins ◽  
Adriana I. S. Formiga ◽  
...  
Keyword(s):  
Weight Loss ◽  
Type 1 Diabetes ◽  
Relative Risk ◽  
Glycated Haemoglobin ◽  
Treatment Delay ◽  
Duration Of Symptoms ◽  
The Mean ◽  
Mean Differences ◽  
New Onset

Abstract Objectives Since the beginning of the COVID-19 pandemic, there has been a consistent decrease in the number of admissions to the emergency department, leading to a delay in the diagnosis of several pathologies. The time from onset of symptoms to the diagnosis of Type 1 diabetes is highly variable. This treatment delay can lead to the appearance of ketoacidosis. Methods Retrospective study of inaugural Type 1 diabetes cases, from March 2016 to March 2021. The pandemic group was considered between March 2020 to March 2021, and the remaining period was considered as pre-pandemic. Clinical variables were analysed: duration of symptoms, weight loss and value of ketonemia and glycated haemoglobin on admission. The mean differences were considered statistically significant at p<0.05. Results 103 inaugural episodes of Type 1 diabetes were registered. The pandemic group had a lower mean age when compared to pre-pandemic group, and 51.7% of the episodes had ketoacidosis with a higher relative risk of ketoacidosis and severe ketoacidosis, when compared the pandemic with pre-pandemic group, there was a longer symptom evolution time (34 vs. 20 days), greater weight loss occurred (9.5% vs. 6.3%), the pH and HCO3 − values were lower (7.30 vs. 7.36 and 16.43 vs. 20.71 mmol/L respectively) and ketonemia was higher (5.9 vs. 2.3 mmol/L). Conclusions The COVID-19 pandemic caused a delay in the diagnosis of Type 1 diabetes, greater length of disease, greater weight loss, higher ketonemia and lower pH and HCO3 −. There was greater ketoacidosis relative risk in pandemic group when compared to pre-pandemic group.

Electrocardiographic data of children with type 1 diabetes mellitus

2021 ◽  
pp. 1-5
Author(s):  
Mehmet Türe ◽  
Alper Akın ◽  
Edip Unal ◽  
Ahmet Kan ◽  
Suat Savaş
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Sudden Death ◽  
Type 1 Diabetes Mellitus ◽  
Qt Dispersion ◽  
Control Group ◽  
Haemoglobin A1c ◽  
Duration Of Diabetes ◽  
And Gender

Abstract Background: Adult patients diagnosed with type 1 diabetes mellitus are at risk for ventricular arrhythmias and sudden cardiac death. Aim: The objective of our study is to evaluate the electrocardiographic data of children diagnosed with type 1 diabetes mellitus and to determine the possibility of arrhythmia in order to prevent sudden death. Methods: Electrocardiographic data of 60 patients diagnosed with type 1 diabetes mellitus and 86 controls, who were compatible with the patient group in terms of age and gender, were compared. Results: The duration of diabetes in our patients with type 1 diabetes mellitus was 5.23 ± 1.76 years, and the haemoglobin A1c levels were 9.63% ± 1.75%. The heart rate, QRS, QT maximum, QT dispersion, QTc minimum, QTc maximum, QTc dispersion, Tp-e maximum, Tp-e maximum/QTc maximum and the JTc were significantly higher compared to the control group. There was no significant correlation between the duration of type 1 diabetes mellitus and HbA1c levels and the electrocardiographic data. Conclusion: We attributed the lack of a significant correlation between the duration of type 1 diabetes mellitus and the haemoglobin A1c levels and the electrocardiographic data to the fact that the duration of diabetes was short, since our patients were children. We believe that patients with type 1 diabetes mellitus should be followed up closely in terms of sudden death, as they have electrocardiographic changes that may cause arrhythmias compared to the control group. However, more studies with longer follow-up periods are necessary to support our data.

A Patient With Type 1 Diabetes, Visual Acuity Loss, and Retinal Thickening

2019 ◽  
Vol 137 (9) ◽  
pp. 1078
Author(s):  
Anat Loewenstein ◽  
Jean-François Korobelnik ◽  
Annabelle A. Okada
Keyword(s):  
Visual Acuity ◽  
Type 1 Diabetes ◽  
Visual Acuity Loss
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