Comparison of intraocular pressure fluctuation before and after cataract surgeries in normal-tension glaucoma patients

2018 ◽  
Vol 29 (5) ◽  
pp. 516-523 ◽  
Author(s):  
Naoki Tojo ◽  
Mitsuya Otsuka ◽  
Atsushi Hayashi
Keyword(s):  
Regression Analysis ◽  
Intraocular Pressure ◽  
Cataract Surgery ◽  
Contact Lens ◽  
Pressure Fluctuations ◽  
Normal Tension Glaucoma ◽  
Open Label ◽  
Before And After ◽  
Contact Lens Sensor ◽  
Harmonic Regression

Purpose: Cataract surgeries have been shown to reduce intraocular pressure. We used a Sensimed Triggerfish® contact lens sensor to compare intraocular pressure levels and their fluctuation between before and after cataract surgeries in patients with normal-tension glaucoma. Methods: This was a prospective open-label study. Thirteen patients with normal-tension glaucoma were included. All patients underwent a 1-month washout and discontinued glaucoma medications during this study. In each eye, intraocular pressure fluctuations over 24 h were measured with the contact lens sensor before and at 3 months after the cataract surgery. We compared intraocular pressure levels and their fluctuation between before and after cataract surgeries. We used two approaches to evaluate the amplitude of intraocular pressure fluctuations: dual-harmonic regression analysis, and measurement of the difference between the maximum and the minimum value. Results: The mean pre-operative intraocular pressure was 14.7 ± 2.2 mm Hg and mean post-operative intraocular pressure was 11.4 ± 2.2 mm Hg. Cataract surgery significantly decreased intraocular pressure (p = 0.0005). In both methods, the post-operative fluctuations in intraocular pressure over 24 h were significantly smaller than their pre-operative counterparts (dual-harmonic regression analysis: p = 0.0171; difference between the maximum and the minimum: p = 0.0398). Conclusion: Cataract surgery decreased both intraocular pressure values and intraocular pressure fluctuations in normal-tension glaucoma patients.

scholarly journals Triggerfish Recording of IOP Patterns in Combined HFDS Minimally Invasive Glaucoma and Cataract Surgery: A Prospective Study

2021 ◽  
Vol 10 (16) ◽  
pp. 3472
Author(s):  
Bojan Pajic ◽  
Mirko Resan ◽  
Brigitte Pajic-Eggspuehler ◽  
Horace Massa ◽  
Zeljka Cvejic
Keyword(s):  
Circadian Rhythm ◽  
Intraocular Pressure ◽  
Minimally Invasive ◽  
Prospective Study ◽  
Cataract Surgery ◽  
High Frequency ◽  
Glaucoma Surgery ◽  
Before And After ◽  
Contact Lens Sensor ◽  
A Prospective Study

Background: The aim of the study is to investigate whether the circadian IOP rhythm can be influenced by combined cataract surgery with high frequency deep sclerotomy (HFDS) and whether intraocular pressure (IOP) can be significantly reduced by HFDS. Methods: In our study 10 patients were included, in whom 24 h IOP monitoring was installed before and after HFDS/cataract surgery using a Triggerfish. HFDS is a minimally invasive glaucoma surgery (MIGS). Results: After performed HFDS combined with cataract surgery, the IOP was reduced from 27.7 ± 2.11 mmHg to 14.4 ± 2.59 mmHg, which is highly significant (p < 0.001). The contact lens sensor (CLS) cosinor analysis pre- and postoperatively showed that the circadian rhythm is not influenced by the surgery, i.e., the circadian IOP rhythm did not show significant differences before and after surgery. Conclusions: HFDS combined with cataract surgery is a potent surgical method that can significantly reduce the IOP. However, the circadian rhythm cannot be changed by the surgery. The acrophase remained during the night in all patients.

scholarly journals The Application of a Contact Lens Sensor in Detecting 24-Hour Intraocular Pressure-Related Patterns

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Sarah C. Xu ◽  
Angela C. Gauthier ◽  
Ji Liu
Keyword(s):  
Intraocular Pressure ◽  
Disease Progression ◽  
Contact Lens ◽  
Open Angle Glaucoma ◽  
Normal Tension Glaucoma ◽  
Angle Closure ◽  
Blink Rate ◽  
Disease States ◽  
Wide Range ◽  
Contact Lens Sensor

Glaucoma is one of the leading causes of blindness worldwide. Recent studies suggest that intraocular pressure (IOP) fluctuations, peaks, and rhythm are important factors in disease advancement. Yet, current glaucoma management remains hinged on single IOP measurements during clinic hours. To overcome this limitation, 24-hour IOP monitoring devices have been employed and include self-tonometry, permanent IOP, and temporary IOP monitoring. This review discusses each IOP measuring strategy and focuses on the recently FDA-approved contact lens sensor (CLS). The CLS records IOP-related ocular patterns for 24 hours continuously. Using the CLS, IOP-related parameters have been found to be associated with the rate of visual field progression in primary open-angle glaucoma, disease progression in primary angle-closure glaucoma, and various clinical variables in ocular hypertension. The CLS has been used to quantify blink rate and limbal strain and measure the circadian rhythm in a variety of disease states including normal-tension glaucoma and thyroid eye disease. The effects of various IOP-lowering interventions were also characterized using the CLS. CLS provides a unique, safe, and well-tolerated way to study IOP-related patterns in a wide range of disease states. IOP-related patterns may help identify patients most at risk for disease progression and assist with the development of tailored treatments.

scholarly journals Circadian intraocular pressure patterns in healthy subjects, primary open angle and normal tension glaucoma patients with a contact lens sensor

2014 ◽  
Vol 93 (1) ◽  
pp. e14-e21 ◽  
Author(s):  
Luca Agnifili ◽  
Rodolfo Mastropasqua ◽  
Paolo Frezzotti ◽  
Vincenzo Fasanella ◽  
Ilaria Motolese ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Contact Lens ◽  
Healthy Subjects ◽  
Normal Tension Glaucoma ◽  
Open Angle ◽  
Contact Lens Sensor

The Fluctuation of Intraocular Pressure Measured by a Contact Lens Sensor in Normal-Tension Glaucoma Patients and Nonglaucoma Subjects

2017 ◽  
Vol 26 (3) ◽  
pp. 195-200 ◽  
Author(s):  
Naoki Tojo ◽  
Shinya Abe ◽  
Masaaki Ishida ◽  
Takaaki Yagou ◽  
Atsushi Hayashi
Keyword(s):  
Intraocular Pressure ◽  
Contact Lens ◽  
Normal Tension Glaucoma ◽  
Contact Lens Sensor

scholarly journals Continuous 24-hour measurement of intraocular pressure in millimeters of mercury (mmHg) using a novel contact lens sensor: Comparison with pneumatonometry

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248211
Author(s):  
Kevin Gillmann ◽  
Robert Wasilewicz ◽  
Kirsten Hoskens ◽  
Sonja Simon-Zoula ◽  
Kaweh Mansouri
Keyword(s):  
Contact Lens ◽  
Open Angle Glaucoma ◽  
Unmet Need ◽  
The Novel ◽  
Open Label ◽  
Fellow Eye ◽  
Corneal Erosion ◽  
Removal Time ◽  
Severe Intensity ◽  
Contact Lens Sensor

Purpose To address the unmet need of continuous IOP monitoring, a Pressure-Measuring Contact Lens (PMCL) was developed to measure IOP in millimeters of mercury (mmHg) continuously over 24 hours. The present study assessed the reliability of the novel PMCL. Methods In this prospective open-label clinical study, healthy and open-angle glaucoma (OAG) subjects were fitted with the PMCL, and pneumatonometry was performed on study eyes (in absence of the PMCL) and on fellow eyes before, during, and after provocative tests. The primary outcome measures were (1) mean IOP difference between same-eye measurements, and (2) percentage of timepoints at which IOP measured by the PMCL was within 5 mmHg of that measured by pneumatonometry in the fellow eye. Results Eight subjects were analysed (4 healthy, 4 OAG). The average difference in successive IOP measurements made by pneumatonometry and with the PMCL was 2.0±4.3mmHg at placement-time, and 6.5±15.2mmHg at removal time. During water drinking test, a significant increase in IOP was detected both by PMCL in the study eye (2.4±2.5mmHg, p = 0.03) and by pneumatonometry in the fellow eye (1.9±1.9mmHg, p = 0.02). Over the 24-hour recording, 88.0% of IOP variations measured by the PMCL were within 5mmHg of that measured with the pneumatonometer in the fellow eye. A transient corneal erosion of severe intensity was observed following removal of the PMCL on one single eye, and may have affected measurement accuracy in that eye. Conclusions This study is a proof-of-concept for this novel PMCL, and its results are encouraging, with a fair accuracy in IOP values measurement and good sensitivity to subtle IOP variations.

Design and fabricate a contact lens sensor with a micro-inductor embedded for intraocular pressure monitoring

2012 ◽  
Author(s):  
Chien-Kai Tseng ◽  
Yu-Chieh Huang ◽  
Shang-Wei Tsai ◽  
Guan-Ting Yeh ◽  
Chung-Hao Chang ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Contact Lens ◽  
Pressure Monitoring ◽  
Contact Lens Sensor

Discrete Portable Measuring Device for Monitoring Noninvasive Intraocular Pressure with a Nano-Structured Sensing Contact Lens Prototype

2012 ◽  
pp. 214-229
Author(s):  
Ana Moya ◽  
Anton Guimerà ◽  
Irene Sánchez ◽  
Vladimir Laukin ◽  
Raúl Martín ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Contact Lens ◽  
Data Transfer ◽  
Measurement Instrument ◽  
Measuring System ◽  
Wireless Data ◽  
Film Sensor ◽  
Measuring Device ◽  
Electronic Measurement ◽  
Contact Lens Sensor

A new portable measuring device for monitoring intraocular pressure with a non invasive system using a prototype of contact lens has been developed. The contact lens is based on a new organic flexible highly piezo-resisitive film sensor that is glued to the central hole of a lens. The measuring system is wire connected to the contact lens and incorporates user interface methods and a Bluetooth link for bi-directional wireless data transfer. The key design aspects of such architecture are discussed in this paper. The system is designed with an architecture that can be integrated in the future in order to be placed in the contact lens. The discrete system is used to validate the electronic measurement operation and the contact lens sensor (CLS). The measurement instrument can calibrate the differences of the nominal value of the sensor and measure resistances variations that are related to pressure variations. The measuring system and the contact lens sensor were tested with an eye phantom and with enucleated pig eyes by applying pressure changes between 7 to 32 mmHg recording the electrical changes with the portable device.

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