Conjunctivitis as a sign of persistent SARS-COV-2 infection? An observational study and report of late symptoms

2021 ◽  
pp. 112067212110565
Author(s):  
Jose Luis Vallejo-Garcia ◽  
L Balia ◽  
R Raimondi ◽  
G Rustioni ◽  
FI Camesasca ◽  
...  
Keyword(s):  
Foreign Body ◽  
Observational Study ◽  
Respiratory Tract ◽  
Recovery Phase ◽  
Nasopharyngeal Swab ◽  
Upper Respiratory Tract ◽  
End Points ◽  
Body Sensation ◽  
Upper Respiratory ◽  
Mean Time

Purpose To investigate if symptomatic conjunctivitis during the recovery phase of the disease could be associated to a persistent presence of SARS-CoV-2 in the upper respiratory tract. Secondary end points were to analyze the presence of SARS-CoV-2 in the conjunctiva of ocular symptomatic patients and to record the presence of ocular disturbances at this point of the disease. Methods An observational study including consecutive COVID19 patients treated at Humanitas Clinical and Research Hospital who were attending for nasopharyngeal swab to confirm the resolution of SARS-CoV-2 infection and end of isolation. We examined 129 consecutive patients from May to June 2020. The primary end point was to determine if symptomatic conjunctivitis at this point of the disease could be associated to a persistent presence of SARS-CoV-2 in the upper respiratory tract. Secondary end points were to analyze the presence of SARS-CoV-2 in the conjunctiva of ocular symptomatic patients and to record the presence of ocular disturbances at this point of the disease. Results One hundred twenty eight patients were included, 9.38% had conjunctivitis, none resulted positive to conjunctival PCR swab test, while two of them had positive nasopharyngeal result. Mean time elapsed since the first COVID-19 positive swab to the time of examination was 6 weeks (  ± 3). The only significant association was the presence of conjunctivitis with older age (65.3  ±  12.7 vs 56.7  +  13.5. p  =  0.046). Nasopharyngeal swab resulted positive in 22 patients (17.19%). While 88 patients (68.2%) did not have any ocular complain during their COVID19 disease. The 40 patients (31.8%) reporting ocular disturbances complained about: redness (25.43%), tearing (19.53%), burning (18.35%), foreign body sensation (17.18%), itching (15.62%), and discharge (12.5%). Conclusion This study showed that late conjunctivitis cannot be considered as a marker of persistent infection when patients are sent to confirm the resolution of SARS-CoV-2 infection.

scholarly journals A combined oro-nasopharyngeal swab is more sensitive than mouthwash in detecting SARS-CoV-2 by a high-throughput PCR assay

2020 ◽  
Author(s):  
Wiebke Michel ◽  
Jacqueline Farber ◽  
Milica Dilas ◽  
Ina Tammer ◽  
Jannik Baar ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Test Performance ◽  
Nasopharyngeal Swab ◽  
Virus Concentration ◽  
Upper Respiratory Tract ◽  
Sterile Water ◽  
Test Results ◽  
Pcr Assay ◽  
Previous Diagnosis ◽  
Upper Respiratory

Objectives: The optimal diagnostic specimen to detect SARS-CoV-2 by PCR in the upper respiratory tract is unclear. Mouthwash fluid has been reported as an alternative to nasopharyngeal and oropharyngeal swabs. We compared mouthwash fluid with a combined oro-nasopharyngeal swab regarding test performance. Methods: We tested asymptomatic persons with a previous diagnosis of COVID-19 and their household contacts. First, a mouthwash (gargling for at least 5 sec) with sterile water was performed. Then, with a single flocked swab the back of the throat and subsequently the nasopharynx were sampled. Samples were inactivated and analysed on a Roche cobas 6800 system with the Roche SARS-CoV-2 test. Results: Of 76 persons, 39 (51%) tested positive for SARS-CoV-2 by oro-nasopharyngeal swab. Mouthwash detected 13 (17%) of these infections but did not detect any additional infection. Samples that were positive in both tests, had lower cycle threshold (Ct)-values for oro-nasopharyngeal samples, indicating a higher virus concentration, compared to samples only positive in oro-nasopharyngeal swabs. Conclusions: Mouthwash is not as sensitive as combined oro-nasopharyngeal swab in detecting upper respiratory tract infection.

Oesophageal foreign body: an unusual presentation

2013 ◽  
Vol 127 (12) ◽  
pp. 1242-1243 ◽  
Author(s):  
M Oyewole ◽  
O Ajayi ◽  
A Hilger
Keyword(s):  
Foreign Body ◽  
Respiratory Tract ◽  
Foreign Bodies ◽  
Emergency Services ◽  
Correct Diagnosis ◽  
Clinical Signs ◽  
General Anaesthetic ◽  
Upper Respiratory Tract ◽  
Lateral Chest ◽  
Upper Respiratory

AbstractObjective:This paper describes and discusses the case of an oesophageal foreign body, in which the patient presented with primarily respiratory clinical signs.Case report:A 17-month-old child, who had ingested a watch battery, presented to emergency services on multiple occasions with upper respiratory tract symptoms. Subsequent radiographs showed the battery in the oesophagus impinging on the trachea. The battery was removed successfully under a general anaesthetic.Conclusion:Large oesophageal foreign bodies can impinge on the trachea causing upper respiratory tract signs. In such cases, anteroposterior and lateral chest films are imperative to make a correct diagnosis.

scholarly journals SARS-CoV-2 Detection in Fecal Sample from a Patient with Typical Findings of COVID-19 Pneumonia on CT but Negative to Multiple SARS-CoV-2 RT-PCR Tests on Oropharyngeal and Nasopharyngeal Swab Samples

Medicina ◽  
2021 ◽  
Vol 57 (3) ◽  
pp. 290
Author(s):  
Barbara Brogna ◽  
Carlo Brogna ◽  
Mauro Petrillo ◽  
Adriana Modestina Conte ◽  
Giulio Benincasa ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Clinical Symptoms ◽  
Nasopharyngeal Swab ◽  
Upper Respiratory Tract ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Negative Results ◽  
Upper Respiratory ◽  
Polymerase Chain ◽  
Pcr Test

Reverse transcriptase polymerase chain reaction (RT-PCR) negative results in the upper respiratory tract represent a major concern for the clinical management of coronavirus disease 2019 (COVID-19) patients. Herein, we report the case of a 43-years-old man with a strong clinical suspicion of COVID-19, who resulted in being negative to multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR tests performed on different oropharyngeal and nasopharyngeal swabs, despite serology having confirmed the presence of SARS-CoV-2 IgM. The patient underwent a chest computed tomography (CT) that showed typical imaging findings of COVID-19 pneumonia. The presence of viral SARS-CoV-2 was confirmed only by performing a SARS-CoV-2 RT-PCR test on stool. Performing of SARS-CoV-2 RT-PCR test on fecal samples can be a rapid and useful approach to confirm COVID-19 diagnosis in cases where there is an apparent discrepancy between COVID-19 clinical symptoms coupled with chest CT and SARS-CoV-2 RT-PCR tests’ results on samples from the upper respiratory tract.

scholarly journals SAT0265 RISK FACTORS FOR INFECTIOUS COMPLICATIONS FOLLOWING RITUXIMAB TREATMENT – MULTICENTER POLISH EXPERIENCE

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1076.2-1076
Author(s):  
A. Masiak ◽  
M. Ziętkiewicz ◽  
K. Wójcik ◽  
K. Wawrzycka-Adamczyk ◽  
M. Madej ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Respiratory Tract ◽  
Soft Tissues ◽  
Infectious Complications ◽  
Prolonged Treatment ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Tract Infections ◽  
Mean Time

Background:Rituximab (RTX) is a B cell depleting monoclonal antibody with proven efficacy in the treatment of ANCA-associated vasculitis (AAV). The infectious complications occur in 15-25%.Objectives:We aimed to assess the frequency and risk factors of infections in patients with AAV receiving RTX among Polish patients.Methods:7 tertiary referral centers experienced in the treatment of vasculitis completed a questionnaire regarding AAV patients treated with RTX.Results:Among 49 patients included in the analysis (47 with GPA, 2 with MPA; 36/73% men; mean age at diagnosis 42,45±14,9 yrs., mean age on RTX initiation 46,14±14,72 yrs.,) at least one infection occurred in 20 patients (40.82%) after mean time of 16,65±16,01 weeks since the administration of RTX. Patients were followed for a mean time of 26,88±21,94 months. There were no differences in the incidence of infectious complications by gender, age, BMI, smoking status, severity of the disease, activity of the disease (BVAS), time from diagnosis to RTX initiation, carriage of staphylococcus aureus in the upper respiratory tract, total dose of CYC before RTX treatment. We didn’t observe severe hypogammaglobulinemia or neutropenia after RTX treatment. 40% of the observed infections occurred during the first month, 35% between second and sixth month of follow-up, while 25% were observed between 6 and 12 months after the RTX initiation. Of the 20 patients who developed infection, 12 (24.5%) had further infections. Antibiotic prophylaxis with trimethoprim–sulfamethoxazole was administered in 40 out of 49 (81.63%). Upper respiratory tract infection was the most common infectious complication (n=11), followed by lower respiratory tract (n=4), soft tissues (n=4) and urinary tract infections (n=4), lacrimal gland abscess (n=2) and abdomen (n=1). In cases with a positive microbial result Staphylococcus aureus (n=4), Klebsiella pneumoniae (n=2), Pseudomonas aeruginosa (n=1), Candida (n=1) and others (n=6) were identified. No fatalities were recorded and only 3 patients had severe infection with the necessity of prolonged treatment.Conclusion:Despite the high number of infections in our group treated with RTX, most of them were not severe. Upper respiratory tract was the most common site of infection.Disclosure of Interests:None declared

scholarly journals Carriage of Mycoplasma pneumoniae in the Upper Respiratory Tract of Symptomatic and Asymptomatic Children: An Observational Study

PLoS Medicine ◽  
2013 ◽  
Vol 10 (5) ◽  
pp. e1001444 ◽  
Author(s):  
Emiel B. M. Spuesens ◽  
Pieter L. A. Fraaij ◽  
Eline G. Visser ◽  
Theo Hoogenboezem ◽  
Wim C. J. Hop ◽  
...  
Keyword(s):  
Observational Study ◽  
Respiratory Tract ◽  
Mycoplasma Pneumoniae ◽  
Upper Respiratory Tract ◽  
Asymptomatic Children ◽  
Upper Respiratory
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