The anatomical sources of neointimal cells in the arteriovenous fistula

2021 ◽  
pp. 112972982110118
Author(s):  
Roberto I Vazquez-Padron ◽  
Laisel Martinez ◽  
Juan C Duque ◽  
Loay H Salman ◽  
Marwan Tabbara
Keyword(s):  
Arteriovenous Fistula ◽  
Intimal Hyperplasia ◽  
Current Knowledge ◽  
Cellular Dynamics ◽  
Relative Contribution ◽  
Effective Delivery ◽  
Transformation Processes

Neointimal cells are an elusive population with ambiguous origins, functions, and states of differentiation. Expansion of the venous intima in arteriovenous fistula (AVF) is one of the most prominent remodeling processes in the wall after access creation. However, most of the current knowledge about neointimal cells in AVFs comes from extrapolations from the arterial neointima in non-AVF systems. Understanding the origin of neointimal cells in fistulas may have important implications for the design and effective delivery of therapies aimed to decrease intimal hyperplasia (IH). In addition, a broader knowledge of cellular dynamics during postoperative remodeling of the AVF may help clarify other transformation processes in the wall that combined with IH determine the successful remodeling or failure of the access. In this review, we discuss the possible anatomical sources of neointimal cells in AVFs and their relative contribution to intimal expansion.

Nitric oxide releasing nanomatrix gel treatment inhibits venous intimal hyperplasia and improves vascular remodeling in a rodent arteriovenous fistula

Biomaterials ◽  
2021 ◽  
pp. 121254
Author(s):  
Maheshika Somarathna ◽  
Patrick TJ. Hwang ◽  
Reid C. Millican ◽  
Grant C. Alexander ◽  
Tatyana Isayeva-Waldrop ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Arteriovenous Fistula ◽  
Intimal Hyperplasia ◽  
Vascular Remodeling ◽  
Gel Treatment ◽  
Nitric Oxide Releasing

Effects of N-acetylcysteine on arterial neo-intimal hyperplasia in rat model of arteriovenous fistula

2018 ◽  
Vol 20 (2) ◽  
pp. 190-194
Author(s):  
Amirmohsen Jalaeefar ◽  
Arash Mohammadi Tofigh ◽  
Atoosa Gharib ◽  
Mohsen Khandaghy ◽  
Mohammad Reza Rahimi
Keyword(s):  
Arteriovenous Fistula ◽  
Rat Model ◽  
Intimal Hyperplasia ◽  
Intima Media Thickness ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Clinical Issue ◽  
Significant Difference ◽  
Hematoxylin And Eosin ◽  
The Mean

Introduction: Arteriovenous fistula is the best choice for vascular access in hemodialysis patients. However, arteriovenous fistula dysfunction is a major clinical issue. The most common cause of arteriovenous fistula failure is intimal hyperplasia. In this study, we have investigated the effect of N-acetylcysteine on neo-intimal hyperplasia after arteriovenous fistula creation in rats. Methods: This study was conducted in 24 rats which were randomly divided into two groups: control and N-acetylcysteine groups. An end-to-side anastomosis was made between the femoral artery and vein. The control group received distilled water intraperitoneally while the animals in N-acetylcysteine group received 300 mg/kg/day of N-acetylcysteine via the same route. After 28 days, the thickness of intima and media was measured using hematoxylin and eosin. Results: There was no significant difference between the two groups regarding age ( p = 0.6) and weight ( p = 0.1). The mean intima thickness in N-acetylcysteine group was significantly less than control group (17 ± 20 and 119 ± 46 µm, respectively; p < 0.001). The mean intima/media thickness in the N-acetylcysteine group was significantly less than control group (0.5 ± 0.63 vs 2.05 ± 1.17 µm; p < 0.001). Conclusion: N-acetylcysteine is effective in inhibiting neo-intimal hyperplasia in a rat model of arteriovenous fistula.

Relative contribution of the TNF-α receptors to murine intimal hyperplasia

2003 ◽  
Vol 284 (5) ◽  
pp. R1213-R1218 ◽  
Author(s):  
Michael A. Zimmerman ◽  
Leonid L. Reznikov ◽  
Amy C. Sorensen ◽  
Craig H. Selzman
Keyword(s):  
Vascular Injury ◽  
Intimal Hyperplasia ◽  
Nuclear Factor Κb ◽  
Arterial Injury ◽  
Receptor Subtype ◽  
Nuclear Factor ◽  
Relative Contribution ◽  
Tnf Α ◽  
Factor Α ◽  
Carotid Arterial

Tumor necrosis factor-α (TNF-α) is an important mediator in the inflammatory response to vascular injury. The present study sought to determine the relative contribution of each TNF-α receptor subtype (p55 and p75) to intimal hyperplasia (IH) and characterize the mechanisms of transcriptional regulation after vascular injury. A murine model of wire carotid arterial injury was employed to induce IH in wild-type (WT), p55-deficient (p55−/−), and p75-deficient (p75−/−) mice. Compared with injured WT and p75−/− animals, p55−/− mice demonstrated a twofold reduction in IH. Additionally, p55−/− mice demonstrated a decrease in expression of nuclear factor-κB mRNA and protein. These observations suggest an important role for the p55 receptor in IH after mechanical endoluminal injury. Suppression of the transcriptional activator nuclear factor-κB may provide a mechanism by which p55-mediated IH is attenuated.

scholarly journals Preoperative Venous Intimal Hyperplasia, Postoperative Arteriovenous Fistula Stenosis, and Clinical Fistula Outcomes

2013 ◽  
Vol 8 (10) ◽  
pp. 1750-1755 ◽  
Author(s):  
Michael Allon ◽  
Michelle L. Robbin ◽  
Carlton J. Young ◽  
Mark H. Deierhoi ◽  
Jeremy Goodman ◽  
...  
Keyword(s):  
Arteriovenous Fistula ◽  
Intimal Hyperplasia ◽  
Arteriovenous Fistula Stenosis

scholarly journals Remodeling and suppression of intimal hyperplasia of vascular grafts with a distal arteriovenous fistula in a rat model

2001 ◽  
Vol 34 (4) ◽  
pp. 701-706 ◽  
Author(s):  
Feng Qin ◽  
Herbert Dardik ◽  
Audwin Pangilinan ◽  
Jody Robinson ◽  
Jennifer Chuy ◽  
...  
Keyword(s):  
Arteriovenous Fistula ◽  
Rat Model ◽  
Intimal Hyperplasia ◽  
Vascular Grafts

scholarly journals Dialysis Arteriovenous Fistula Failure and Angioplasty: Intimal Hyperplasia and Other Causes of Access Failure

2017 ◽  
Vol 69 (1) ◽  
pp. 147-151 ◽  
Author(s):  
Juan C. Duque ◽  
Marwan Tabbara ◽  
Laisel Martinez ◽  
Jose Cardona ◽  
Roberto I. Vazquez-Padron ◽  
...  
Keyword(s):  
Arteriovenous Fistula ◽  
Intimal Hyperplasia

scholarly journals An Arteriovenous Fistula Model of Intimal Hyperplasia for Evaluation of a Nitinol U-Clip Anastomosis

2012 ◽  
Vol 43 (2) ◽  
pp. 224-231 ◽  
Author(s):  
R.L. Varcoe ◽  
A.B.P. Teo ◽  
M.H. Pelletier ◽  
Y. Yu ◽  
J.-L. Yang ◽  
...  
Keyword(s):  
Arteriovenous Fistula ◽  
Intimal Hyperplasia

scholarly journals Pre-existing and Postoperative Intimal Hyperplasia and Arteriovenous Fistula Outcomes

2016 ◽  
Vol 68 (3) ◽  
pp. 455-464 ◽  
Author(s):  
Marwan Tabbara ◽  
Juan C. Duque ◽  
Laisel Martinez ◽  
Luis A. Escobar ◽  
Wensong Wu ◽  
...  
Keyword(s):  
Arteriovenous Fistula ◽  
Intimal Hyperplasia

Modeling nanomaterial fate and uptake in the environment: current knowledge and future trends

2016 ◽  
Vol 3 (2) ◽  
pp. 323-345 ◽  
Author(s):  
M. Baalousha ◽  
G. Cornelis ◽  
T. A. J. Kuhlbusch ◽  
I. Lynch ◽  
C. Nickel ◽  
...  
Keyword(s):  
Environmental Fate ◽  
Current Knowledge ◽  
Future Trends ◽  
Environmental Transport ◽  
Transformation Processes

A schematic summary of the most important transformation processes a NM may undergo during environmental transport, and the parameters of highest importance for inclusion in models of NM environmental fate and uptake.

scholarly journals Similar degree of intimal hyperplasia in surgically detected stenotic and nonstenotic arteriovenous fistula segments: a preliminary report

Surgery ◽  
2018 ◽  
Vol 163 (4) ◽  
pp. 866-869 ◽  
Author(s):  
Juan C. Duque ◽  
Marwan Tabbara ◽  
Laisel Martinez ◽  
Angela Paez ◽  
Guillermo Selman ◽  
...  
Keyword(s):  
Arteriovenous Fistula ◽  
Intimal Hyperplasia ◽  
Preliminary Report ◽  
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