Daylight-Mediated Photodynamic Therapy With Methyl Aminolevulinate in Actinic Keratosis Treatment

2018 ◽  
Vol 22 (3) ◽  
pp. 267-272 ◽  
Author(s):  
Shantel D. J. Demay ◽  
Kunal Sharma ◽  
Sheetal Sapra ◽  
Rahul Sapra ◽  
Priya Sapra
Keyword(s):  
Photodynamic Therapy ◽  
Patient Satisfaction ◽  
Actinic Keratosis ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Level Of Satisfaction ◽  
Canadian Population ◽  
The Face ◽  
Methyl Aminolevulinate ◽  
Suitable Treatment

Background: Research has shown daylight-mediated photodynamic therapy (PDT) for the treatment of actinic keratosis (AK) to be effective, tolerable, and convenient, with excellent patient satisfaction and cosmesis. Although success has been demonstrated in areas with similar latitudes to Switzerland and Scandinavia, this treatment has not been studied in a Canadian population. Objectives: The purpose of this study is to investigate the effectiveness, safety, and patient satisfaction of daylight-mediated methyl 5-aminolevulinate (MAL)–PDT to make recommendations for its use in Canadian practice. Methods: A retrospective chart review of patients who received treatment of daylight-mediated MAL-PDT for the indication of AK at the Institute of Cosmetic and Laser Surgery in Oakville, Ontario, between 2009 and 2016. Results: A total of 112 patients were included, consisting of 94 males and 18 females with a mean age of 63.79 years. A total of 177 sites were treated among all patients, mostly consisting of the face (n = 92) and scalp (n = 55). A total of 13.4% of patients experienced side effects, the most common being redness (n = 4) and scabbing (n = 4). Of the 42 patients who expressed their level of satisfaction, 83.3% reported being happy with the treatment, χ2(1) = 18.67, P ≤ .05; 6.3% of patients were noted to be completely clear, 86.6% had a good response, 0.9% had a mild response, and 0% had no response, χ2(1) = 101.04, P ≤ .05. Conclusions: Daylight-mediated MAL-PDT is a suitable treatment option for AK lesions in a Canadian population due to the demonstrated efficacy, patient satisfaction, tolerability, and convenience.

Sequential methyl-aminolevulinate daylight photodynamic therapy and diclofenac plus hyaluronic acid gel treatment for multiple actinic keratosis evaluation

2018 ◽  
Vol 31 (6) ◽  
pp. e12710 ◽  
Author(s):  
Carmen Cantisani ◽  
Giovanni Paolino ◽  
Marco Scarnò ◽  
Dario Didona ◽  
Mariagrazia Tallarico ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Hyaluronic Acid ◽  
Actinic Keratosis ◽  
Gel Treatment ◽  
Methyl Aminolevulinate ◽  
Acid Gel ◽  
Hyaluronic Acid Gel

scholarly journals Topical treatments and photodynamic therapy for actinic keratosis of the face and scalp

2019 ◽  
Author(s):  
Kelly Foley ◽  
Aditya K Gupta ◽  
George Martin ◽  
John A Tweed ◽  
Elmer Villanueva ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Actinic Keratosis ◽  
The Face ◽  
Topical Treatments

IMPACT OF COMPENSATORY HYPERHIDROSIS ON PATIENT SATISFACTION AFTER ENDOSCOPIC THORACIC SYMPATHECTOMY

Neurosurgery ◽  
2009 ◽  
Vol 64 (3) ◽  
pp. 511-518 ◽  
Author(s):  
Mark Chwajol ◽  
Ignacio J. Barrenechea ◽  
Shamik Chakraborty ◽  
Jonathan B. Lesser ◽  
Cliff P. Connery ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
Retrospective Chart Review ◽  
Definitive Treatment ◽  
P Value ◽  
Endoscopic Thoracic Sympathectomy ◽  
Compensatory Hyperhidrosis ◽  
Thoracic Sympathectomy ◽  
Level Of Satisfaction ◽  
Focal Hyperhidrosis ◽  
The Impact

Abstract OBJECTIVE Endoscopic thoracic sympathectomy (ETS) remains the definitive treatment for primary focal hyperhidrosis. Compensatory hyperhidrosis (CH) is a significant drawback of ETS. We sought to identify the predictors for the development of severe CH after ETS, its anatomic locations, and its frequency of occurrence, and we analyzed the impact of CH on patient satisfaction with ETS. METHODS Bilateral ETS for primary focal hyperhidrosis was performed in 220 patients, and a retrospective chart review was conducted. Follow-up evaluation was conducted using a telephone questionnaire, and 73% of all patients were contacted. Patients' responses regarding CH and their level of satisfaction after ETS were analyzed. Statistical analysis was performed using SPSS software (Version 14.0; SPSS, Inc., Chicago, IL). A P value of <0.05 was considered statistically significant. RESULTS Some degree of CH developed in 94% of patients. The number of levels treated was not related to the occurrence of severe CH. Isolated T3 ganglionectomy led to a significantly lower incidence of severe CH, when compared with all other levels (P < 0.03). Ninety percent of patients were satisfied with the procedure. The development of severe CH, as opposed to mild or moderate CH, significantly correlated with a lower satisfaction rate (P = 0.003). CONCLUSION CH is common after ETS procedures, and the occurrence of severe, but not mild or moderate, CH is a major source of dissatisfaction after ETS. The overall occurrence of severe CH is reduced after T3 ganglionectomy as opposed to ganglionectomies performed at all other levels. The level of satisfaction with ETS is high.

scholarly journals Computed Tomography Measurement of Hepatic Steatosis: Prevalence of Hepatic Steatosis in a Canadian Population

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Malcolm M. Wells ◽  
Zhe Li ◽  
Bryan Addeman ◽  
Charles A. McKenzie ◽  
Amol Mujoomdar ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Adipose Tissue ◽  
Liver Disease ◽  
Hepatic Steatosis ◽  
Subcutaneous Adipose Tissue ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Canadian Population ◽  
Adipose Tissue Volume ◽  
Subcutaneous Adipose

Background/Aims. Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease that can progress to cirrhosis and hepatocellular carcinoma. This retrospective chart review investigated the incidence of hepatic steatosis in London, Ontario, Canada.Methods. A retrospective chart review was performed on emergency room (ER) patients undergoing nonscheduled computed tomography (CT) imaging over a six-month period in London, Ontario. CT images and reports were examined to determine presence of steatosis. Analyses of the electronic chart for a period of six months following the CT and communication with the patients’ family doctors were used to determine if there was follow-up. Waist circumference, subcutaneous fat depth, and abdominal fat volumes were calculated.Results. 48/450 patients meeting inclusion criteria were identified by radiology as having steatosis, with 34/40 (85%) family physicians unaware of the finding. 24.7% (100/405) of patients met standard CT criteria for steatosis, 40 of which were reported by the radiologist. Waist circumference, subcutaneous adipose tissue depth, subcutaneous adipose tissue volume, and visceral adipose tissue volume were significantly associated with steatosis.Conclusions. The hepatic steatosis prevalence we report is the first reported in a Canadian population. Early identification of steatosis will become more important as new pharmacologic therapies arise.

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