Fatigue in multiple sclerosis presenting as acute relapse: subjective and objective assessment

2007 ◽  
Vol 14 (2) ◽  
pp. 274-277 ◽  
Author(s):  
Peter Flachenecker ◽  
Heike Meissner
Keyword(s):  
Multiple Sclerosis ◽  
Time Course ◽  
Objective Assessment ◽  
Neuropsychological Testing ◽  
High Dose ◽  
Subjective Symptoms ◽  
High Dose Corticosteroid ◽  
Acute Relapse ◽  
Dose Corticosteroid ◽  
Neuropsychological Methods

We report on a patient with multiple sclerosis (MS) who presented with fatigue as the only manifestation of an acute MS relapse. Fatigue was assessed by the `Würzburg Fatigue Inventory in MS (WEIMuS)' scale and confirmed by neuropsychological testing of attention. After high-dose corticosteroid therapy, subjective symptoms were completely abolished. The improvement was corroborated by both, the WEIMuS score and neuropsychological testing. MS-related fatigue may be the only symptom of an acute MS relapse, and neuropsychological methods may be used to objectively assess and follow the time course of this common and disabling symptom. Multiple Sclerosis 2008; 14: 274—277. http://msj.sagepub.com

Sleep-EEG effects of high-dose corticosteroid treatment in multiple sclerosis

2005 ◽  
Vol 38 (05) ◽  
Author(s):  
MC Rosenhagen ◽  
P Schüssler ◽  
U Schmidt ◽  
A Yassouridis ◽  
A Steiger
Keyword(s):  
Multiple Sclerosis ◽  
Corticosteroid Treatment ◽  
Sleep Eeg ◽  
High Dose ◽  
High Dose Corticosteroid ◽  
Dose Corticosteroid

scholarly journals High-dose corticosteroid pulse therapy increases the survival rate in COVID-19 patients at risk of hyper-inflammatory response

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0243964
Author(s):  
Miguel Ángel López Zúñiga ◽  
Aida Moreno-Moral ◽  
Ana Ocaña-Granados ◽  
Francisco Andrés Padilla-Moreno ◽  
Alba María Castillo-Fernández ◽  
...  
Keyword(s):  
At Risk ◽  
Inflammatory Response ◽  
Time Course ◽  
Survival Rates ◽  
Pulse Therapy ◽  
High Dose ◽  
High Dose Corticosteroid ◽  
Laboratory Markers ◽  
Patients At Risk ◽  
Dose Corticosteroid

Objective Test whether high dose corticosteroid pulse therapy (HDCPT) with either methylprednisolone or dexamethasone is associated with increased survival in COVID-19 patients at risk of hyper-inflammatory response. Provide some initial diagnostic criteria using laboratory markers to stratify these patients. Methods This is a prospective observational study, 318 met the inclusion criteria. 64 patients (20.1%) were treated with HDCPT by using at least 1.5mg/kg/24h of methylprednisolone or dexamethasone equivalent. A multivariate Cox regression (controlling for co-morbidities and other therapies) was carried out to determine whether HDCPT (among other interventions) was associated with decreased mortality. We also carried out a 30-day time course analysis of laboratory markers between survivors and non-survivors, to identify potential markers for patient stratification. Results HDCPT showed a statistically significant decrease in mortality (HR = 0.087 [95% CI 0.021–0.36]; P < 0.001). 30-day time course analysis of laboratory marker tests showed marked differences in pro-inflammatory markers between survivors and non-survivors. As diagnostic criteria to define the patients at risk of developing a COVID-19 hyper-inflammatory response, we propose the following parameters (IL-6 > = 40 pg/ml, and/or two of the following: C-reactive protein > = 100 mg/L, D-dimer > = 1000 ng/ml, ferritin > = 500 ng/ml and lactate dehydrogenase > = 300 U/L). Conclusions HDCPT can be an effective intervention to increase COVID-19 survival rates in patients at risk of developing a COVID-19 hyper-inflammatory response, laboratory marker tests can be used to stratify these patients who should be given HDCPT. This study is not a randomized clinical trial (RCT). Future RCTs should be carried out to confirm the efficacy of HDCPT to increase the survival rates of COVID-19.

High-Dose Corticosteroid Pulse Therapy Increases the Survival Rate in COVID-19 Patients at Risk of Cytokine Storm

2020 ◽  
Author(s):  
Miguel Ángel López-Zúñiga ◽  
Aida Moreno-Moral ◽  
Ana Ocaña-Granados ◽  
Francisco Padilla-Moreno ◽  
Alba María Castillo-Fernández ◽  
...  
Keyword(s):  
At Risk ◽  
Survival Rate ◽  
Pulse Therapy ◽  
High Dose ◽  
Cytokine Storm ◽  
High Dose Corticosteroid ◽  
Patients At Risk ◽  
Corticosteroid Pulse Therapy ◽  
Dose Corticosteroid
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