Dramatic worsening following plasma exchange in severe post-natalizumab withdrawal multiple sclerosis relapse

We report the case of a young woman with multiple sclerosis who discontinued natalizumab twice and experienced a severe relapse following each natalizumab withdrawal. The first relapse was successfully treated by intravenous methylprednisolone (IVMP). In contrast the second relapse was unresponsive to IVMP. Subsequent treatment by plasma exchanges (PLEX) was followed by a dramatic neurological worsening. This case suggests that PLEX after natalizumab discontinuation may increase relapse severity.

Download Full-text

Therapeutic plasma exchange in the treatment of severe multiple sclerosis relapse: Twelve years of experience in Belgrade, Serbia

Journal of the Neurological Sciences ◽

10.1016/j.jns.2019.10.320 ◽

2019 ◽

Vol 405 ◽

pp. 55

Author(s):

S. Mesaros ◽

T. Pekmezovic ◽

J. Ivanovic ◽

V. Martinovic ◽

D. Sokic ◽

...

Keyword(s):

Multiple Sclerosis ◽

Plasma Exchange ◽

Therapeutic Plasma Exchange ◽

Years Of Experience ◽

Multiple Sclerosis Relapse

Download Full-text

Role of Therapeutic Plasma Exchange in Treatment of Tumefactive Multiple Sclerosis-Associated Low CD4 and CD8 Levels

Case Reports in Neurology ◽

10.1159/000448704 ◽

2016 ◽

Vol 8 (2) ◽

pp. 179-184 ◽

Cited By ~ 1

Author(s):

Kristen Lew ◽

Nishith Mewada ◽

Sahana Ramanujam ◽

Bahareh Hassanzadeh ◽

John E. Donahue ◽

...

Keyword(s):

Multiple Sclerosis ◽

Central Nervous System ◽

Plasma Exchange ◽

Demyelinating Disease ◽

Therapeutic Plasma Exchange ◽

Healthy Male ◽

Intravenous Methylprednisolone ◽

Initiation Of Therapy ◽

Tumefactive Multiple Sclerosis

We report a 35-year-old healthy male who developed central nervous system inflammatory demyelinating disease consistent with tumefactive multiple sclerosis. About 2 weeks after onset of symptoms and prior to initiation of therapy, the patient had lymphopenia and low CD4 and CD8 levels. His lymphocyte count was 400 cells/µl (850–3,900 cells/µl), CD4 was 193 cells/µl (490–1,740 cells/µl) and CD8 was 103 cells/µl (180–1,170 cells/µl). He was treated with intravenous methylprednisolone followed by therapeutic plasma exchange, the levels of CD4 and CD8 normalized, and ultimately, he recovered completely.

Download Full-text

POI13 Acute respiratory failure in a multiple sclerosis relapse: successful treatment with plasma exchange

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp.2010.226340.154 ◽

2010 ◽

Vol 81 (11) ◽

pp. e55-e55

Author(s):

M. Maguire ◽

P. Newman ◽

J. Fuller

Keyword(s):

Multiple Sclerosis ◽

Respiratory Failure ◽

Acute Respiratory Failure ◽

Plasma Exchange ◽

Successful Treatment ◽

Multiple Sclerosis Relapse

Download Full-text

Psychotic reaction as a manifestation of multiple sclerosis relapse treated with plasma exchange

Neurological Sciences ◽

10.1007/s10072-011-0712-3 ◽

2011 ◽

Vol 33 (2) ◽

pp. 379-382 ◽

Cited By ~ 6

Author(s):

Tereza Gabelić ◽

Ivan Adamec ◽

Anamarija Mrđen ◽

Milan Radoš ◽

Vesna V. Brinar ◽

...

Keyword(s):

Multiple Sclerosis ◽

Plasma Exchange ◽

Multiple Sclerosis Relapse ◽

Psychotic Reaction

Download Full-text

Factors that may contribute to multiple sclerosis relapse in Saudi Arabia

International Journal of Medicine in Developing Countries ◽

10.24911/ijmdc.51-1578608055 ◽

2020 ◽

pp. 1721-1733

Author(s):

Naif Alomairi ◽

Sultan Bamusa ◽

Mohammed Alzeer ◽

Sultan Alamri

Keyword(s):

Multiple Sclerosis ◽

Saudi Arabia ◽

Multiple Sclerosis Relapse

Download Full-text

Faculty Opinions recommendation of Increased risk of multiple sclerosis relapse after in vitro fertilisation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717957408.793462784 ◽

2012 ◽

Author(s):

Pedro Barri

Keyword(s):

Multiple Sclerosis ◽

In Vitro Fertilisation ◽

Multiple Sclerosis Relapse ◽

Increased Risk

Download Full-text

Faculty Opinions recommendation of Comparing Plasma Exchange to Escalated Methyl Prednisolone in Refractory Multiple Sclerosis Relapses.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737136714.793571993 ◽

2020 ◽

Author(s):

Helmut Wilhelm

Keyword(s):

Multiple Sclerosis ◽

Plasma Exchange ◽

Methyl Prednisolone

Download Full-text

Multiple sclerosis: Is there a risk of worsening after yellow fever vaccination?

Multiple Sclerosis Journal ◽

10.1177/13524585211006372 ◽

2021 ◽

pp. 135245852110063

Author(s):

Caroline Papeix ◽

Julie Mazoyer ◽

Elisabeth Maillart ◽

Caroline Bensa ◽

Anne-Laure Dubessy ◽

...

Keyword(s):

Multiple Sclerosis ◽

Cohort Study ◽

Yellow Fever ◽

Yellow Fever Vaccine ◽

Relapsing Remitting ◽

Annualized Relapse Rate ◽

National Cohort ◽

First Relapse ◽

Yellow Fever Vaccination ◽

Relapsing Remitting Multiple Sclerosis

Background: Yellow fever vaccine (YFV) is not advised for multiple sclerosis (MS) patients because of the potential risk of post-vaccine relapses. Objective: To assess the risk of relapsing-remitting multiple sclerosis (RR-MS) worsening after YFV. Methods: Non-interventional observational retrospective, exposed/non-exposed cohort study nested in the French national cohort including MS. Results: 128 RR-MS were included. The 1-year annualized relapse rate (ARR) following YFV did not differ between exposed: 0.219 (0.420) and non-exposed subjects: 0.208 (0.521) ( p = 0.92). Time to first relapse was not different between groups (adjusted hazard ratio (HR) = 1.33; 95% confidence interval (CI) = 0.53–3.30, p = 0.54). Conclusion: These results suggest that YFV does not worsen the course of RR-MS.

Download Full-text