Faculty Opinions recommendation of Increased risk of multiple sclerosis relapse after in vitro fertilisation.

2012 ◽  
Author(s):  
Pedro Barri
Keyword(s):  
Multiple Sclerosis ◽  
In Vitro Fertilisation ◽  
Multiple Sclerosis Relapse ◽  
Increased Risk

scholarly journals Increased risk of multiple sclerosis relapse after in vitro fertilisation

2012 ◽  
Vol 83 (8) ◽  
pp. 796-802 ◽  
Author(s):  
Laure Michel ◽  
Yohann Foucher ◽  
Sandra Vukusic ◽  
Christian Confavreux ◽  
Jérome de Sèze ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
In Vitro Fertilisation ◽  
Multiple Sclerosis Relapse ◽  
Increased Risk

scholarly journals HERV-K18 Env Expression and the Potential Association With TGF-β and Epstein–Barr Virus Infection in the Presence and the Absence of Vitamin D in Multiple Sclerosis Patients

2021 ◽  
Author(s):  
Tayebeh Latifi ◽  
Majid Teymoori-Rad ◽  
Ahmad Nejati ◽  
Shohreh Shahmahmoodi ◽  
Farhad Rezaei ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Real Time ◽  
Real Time Pcr ◽  
Epstein Barr Virus Infection ◽  
Healthy Controls ◽  
Increased Risk ◽  
Multiple Sclerosis Patients ◽  
Vitro Effect

Abstract Previous studies have reported that Human endogenous retroviruses (HERVs) such as HERV-K18 is associated with an increased risk of multiple sclerosis (MS). The present study aimed to evaluate the association between the expression of HERV-K18 env, TGF-β, and in vitro effect of EBV infection on the expression level of HERV-K18 env in PBMC of MS patients in both presence and absence of vitamin D (1,25-OHD). The levels of HERV-K18 env was measured in peripheral blood mononuclear cells (PBMCs) from 20 MS patients and 20 healthy controls by quantitative real-time PCR. PBMCs were further treated with EBV in the presence or the absence of vitamin D. After 72 hours, cells were collected for measurement of HERV-K18 env expression using Real-time PCR. While the expression of HERV-K18 env was significantly higher in MS patients than healthy controls, the expression of TGF–β was found to be significantly lower in MS patients compare to healthy controls. Interestingly, an inverse correlation was found between HERV-K18 env expression and TGF-β expression in MS patients but not for healthy controls. Although in vitro stimulated PBMCs with EBV showed no significant differences in terms of HERV-K18 expression, EBV infected cells revealed different patterns in the presence and the absence of vitamin D treatment. These findings not only support the important role of HERV-K18 env expression but also highlight the plausible interactions with different risk factors in MS.

Increase in multiple sclerosis relapse rate following in vitro fertilization

Neurology ◽  
2006 ◽  
Vol 66 (8) ◽  
pp. 1280-1281 ◽  
Author(s):  
D. -A. Laplaud ◽  
E. Leray ◽  
P. Barriere ◽  
S. Wiertlewski ◽  
T. Moreau
Keyword(s):  
Multiple Sclerosis ◽  
In Vitro Fertilization ◽  
Relapse Rate ◽  
Vitro Fertilization ◽  
Multiple Sclerosis Relapse

scholarly journals Pregnancy outcome in women with atrial septal defect: associated with in vitro fertilisation and pre-eclampsia

Open Heart ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. e001148
Author(s):  
Sebastian Udholm ◽  
Louise Udholm ◽  
Camilla Nyboe ◽  
Ulrik Schiøler Kesmodel ◽  
Vibeke Elisabeth Hjortdal
Keyword(s):  
Atrial Septal Defect ◽  
Septal Defect ◽  
Reference Group ◽  
Reference Sample ◽  
Perinatal Outcomes ◽  
Population Based ◽  
In Vitro Fertilisation ◽  
Maternal Characteristics ◽  
Increased Risk

ObjectiveTo investigate in vitro fertilisation (IVF) in women with atrial septal defect (ASD), and to examine the maternal characteristics and outcome of pregnancy, as well as the fetal outcome of infants born by women with ASD.MethodsWe used population-based registries in this nationwide cohort study, including Danish individuals born before 1994 who received an ASD diagnosis between 1959 and 2014. Patients were compared with a random reference sample (ratio of 10 citizens per patient) matched by sex and age. The Danish Medical Birth Register (DMBR) contains data on all pregnancies and births in Denmark from 1977 to present. Risk of IVF treatment as well as maternal, pregnancy and fetal outcomes were compared.ResultsA total of 2277 Danish patients had a validated ASD diagnosis. Of these, 310 women were identified in the DMBR. Women with ASD had an increased risk of receiving IVF treatment (HR 3.14, 95% CI 2.1 to 4.7, p<0.0001), and a higher proportion of patients received IVF treatment when compared with the reference cohort (10.6% vs 3.2%; p<0.001). Furthermore, patients had more multiple births. Looking at singleton pregnancies (n=519), pre-eclampsia occurred more frequently in patients with ASD during pregnancy (6.7% vs 2.3%; p<0.001). Infants from mothers with ASD were found to have perinatal outcomes comparable to those of infants from the reference group.ConclusionWomen with ASD had an increased risk of and received more IVF treatment than the reference group. The outcome of pregnancy in these patients were generally uneventful, however, we did confirm that pre-eclampsia occurred more frequently.

scholarly journals Effectiveness and safety of in vitro maturation of oocytes versus in vitro fertilisation in women with high antral follicle count: study protocol for a randomised controlled trial

BMJ Open ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. e023413 ◽  
Author(s):  
Lan N Vuong ◽  
Vu N A Ho ◽  
Tuong M Ho ◽  
Vinh Q Dang ◽  
Tuan H Phung ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
In Vitro Maturation ◽  
Controlled Trial ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
In Vitro Fertilisation ◽  
Increased Risk ◽  
Patient Consent ◽  
Randomised Controlled

IntroductionIn vitro maturation (IVM) is a potential alternative to conventional in vitro fertilisation (IVF) to avoid ovarian hyperstimulation syndrome (OHSS). This is particularly relevant in women with a high antral follicle count (AFC) and/or polycystic ovary syndrome (PCOS), who are at increased risk for OHSS. However, no randomised controlled trials of IVM versus IVF in women with high AFC have reported both pregnancy and OHSS rates. The aim of this study is to compare the effectiveness and safety of one IVM cycle and one IVF with segmentation cycle within women with PCOS or high AFC-related subfertility.Methods and analysisThis randomised controlled trial will be conducted at a specialist IVF centre in Vietnam. Eligible subfertile women with PCOS and/or high AFC will be randomised to undergo either IVM or IVF. The primary outcome is live birth after the first embryo transfer of the started treatment cycle. Cycles in which no embryo is available for transfer will be considered as failures. The study has a non-inferiority design, with a maximal acceptable between-group difference of 5%. Rates of OHSS will also be reported.Ethics and disseminationEthical approval was obtained from the participating centre, and informed patient consent was obtained before study enrolment. Results of the study will be submitted for publication in a peer-reviewed journal.Trial registration numberNCT03405701; Pre-results.

Association Between Twin Discordance at 6–9 Weeks' of Gestation and Birthweight Complications

2010 ◽  
Vol 13 (4) ◽  
pp. 389-392 ◽  
Author(s):  
Kirsten Palmer ◽  
Pavitra Delpachitra ◽  
Joseph Onwude ◽  
Luk Rombauts ◽  
Simon Meagher ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
First Trimester ◽  
In Vitro Fertilisation ◽  
Crown Rump Length ◽  
Increased Risk ◽  
Twin Pregnancies

AbstractTwins achieved through in-vitro fertilisation often undergo a viability ultrasound at 6–9 weeks of gestation. The presence of inter-twin crown-rump length discordance at this stage is not an uncommon finding; however the clinical significance of this is unknown. We analyzed 218 dichorionic twin pregnancies, producing two live fetuses > 24 weeks gestation, to determine whether inter-twin discordance (≥ 85th centile) in the mid-first trimester was associated with birthweight discordance (> 20%), or small for gestational age (< 10th centile). The incidence of birthweight discordance and small for gestational age infants were determined, with no increased risk found for the discordant population. This may provide some reassurance to treating clinicians.

scholarly journals Maternal Loeys–Dietz syndrome (transforming growth factor ligand 2) in a twin pregnancy: Case report and discussion

2019 ◽  
Vol 7 ◽  
pp. 2050313X1985253 ◽  
Author(s):  
Homira Bashari ◽  
Alexandra Brooks ◽  
Orla O’Brien ◽  
Shaun Brennecke ◽  
Dominica Zentner
Keyword(s):  
Twin Pregnancy ◽  
Autosomal Dominant ◽  
Transforming Growth Factor ◽  
Connective Tissue Disorder ◽  
In Vitro Fertilisation ◽  
Joint Decision ◽  
Vascular Assessment ◽  
Increased Risk ◽  
Preconception Counselling

Loeys–Dietz syndrome is a rare autosomal dominant connective tissue disorder. Pregnant women with Loeys–Dietz syndrome are at increased risk of serious vascular and visceral complications, including aortic dissection and uterine rupture. Multidisciplinary tertiary management aims to mitigate such complications by preconception counselling and vascular assessment, medical therapy, regular echocardiography in pregnancy and joint decision-making re-mode and timing of delivery. We report an in vitro fertilisation twin pregnancy in a woman with Loeys–Dietz syndrome first seen at our institution at 26 weeks’ gestation. After monitoring via serial echocardiograms, caesarean delivery occurred at 30 + 1 weeks’ gestation to allow planned delivery with suspected fetal growth restriction before uterine distension was considered an indication. The patient was discharged on Day 9 with a planned early aortic root replacement due to an increase in diameter from 39 to 43 mm, followed by the discharge of twin boys at term equivalent.

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