Serum angiotensin converting enzyme(ACE) activity in various chronic liver diseases and its clinical significance.

Abstract Angiotensin-converting enzyme (ACE) was measured in serum of 187 healthy children between the ages six months and 18 years. Results were pooled for five-year age intervals and compared with the reference values for adults that we previously determined [Clin Chem 1986;32:884-6). Results for each age group were also studied as a function of sex. Children had higher ACE activities in serum than did adults (P less than 0.001), but these activities were age-related only from age four to 18 years. Adolescents showed sex-related differences, with higher serum ACE activities in boys than in girls (P less than 0.05). Both sex- and age-related differences may be related to a steroid hormonal regulation of ACE biosynthesis. We also verified that children with sarcoidosis (n = 20) had significantly increased serum ACE activity. Such physiological variations in serum ACE activity must be taken into account for diagnosing sarcoidosis in children, for following the course of the disease, and for evaluating the accuracy of therapy.

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The Clinical Significance of GP73 in Immunologically Mediated Chronic Liver Diseases: Experimental Data and Literature Review

Clinical Reviews in Allergy & Immunology ◽

10.1007/s12016-017-8655-y ◽

2017 ◽

Vol 54 (2) ◽

pp. 282-294 ◽

Cited By ~ 12

Author(s):

Mingjie Yao ◽

Leijie Wang ◽

Patrick S. C. Leung ◽

Yanmei Li ◽

Shuhong Liu ◽

...

Keyword(s):

Experimental Data ◽

Literature Review ◽

Clinical Significance ◽

Liver Diseases ◽

Chronic Liver ◽

Chronic Liver Diseases

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The potential role of serum angiotensin-converting enzyme in coronavirus disease 2019

BMC Infectious Diseases ◽

10.1186/s12879-020-05619-x ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Zhe Zhu ◽

Ting Cai ◽

Lingyan Fan ◽

Kehong Lou ◽

Xin Hua ◽

...

Keyword(s):

Angiotensin Converting Enzyme ◽

Clinical Condition ◽

Recovery Phase ◽

Control Group ◽

Converting Enzyme ◽

Baseline Serum ◽

Serum Angiotensin Converting Enzyme ◽

Severe Group ◽

Ace Activity

Abstract Background To explore the clinical significance of serum angiotensin-converting enzyme (ACE) activity in coronavirus disease 2019 (COVID-19). Methods In this retrospective study, a total of 136 consecutive patients with confirmed COVID-19 were recruited. Demographic and clinical data were recorded. The serum ACE activity was measured at baseline and during the recovery phase, and its relationship with clinical condition was analyzed. Results Of the 136 patients with confirmed COVID-19, the 16 severe patients were older and had a higher body mass index (BMI) and proportion of hypertension than the 120 nonsevere patients. In comparison to those of normal controls, the baseline serum ACE activities of subjects in the severe group and nonsevere group were decreased, with the lowest level in the severe group. However, the serum ACE activity increased in the recovery phase, and there were no significant differences among the severe group, nonsevere group and normal control group. Conclusion Serum ACE activity could be used as a marker to reflect the clinical condition of COVID-19 since low activity was associated with the severity of COVID-19 at baseline, and the activity increased with the remission of the disease.

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Prevalence and Clinical Significance of Immunoglobulin A Antibodies against Tissue Transglutaminase in Patients with Diverse Chronic Liver Diseases

Clinical and Diagnostic Laboratory Immunology ◽

10.1128/cdli.12.8.941-948.2005 ◽

2005 ◽

Vol 12 (8) ◽

pp. 941-948 ◽

Cited By ~ 15

Author(s):

Anastasios E. Germenis ◽

Efthalia E. Yiannaki ◽

Kalliopi Zachou ◽

Violeta Roka ◽

Sotirios Barbanis ◽

...

Keyword(s):

Liver Disease ◽

Clinical Significance ◽

Liver Diseases ◽

Tissue Transglutaminase ◽

Immunoglobulin A ◽

Chronic Liver ◽

Intestinal Biopsy ◽

Enzyme Linked Immunosorbent Assay ◽

Chronic Liver Diseases ◽

Hla Dq

ABSTRACT The prevalence of celiac disease (CD) and the prevalence and clinical significance of anti-tissue transglutaminase (tTG) antibodies (tTGAbs) in a large series of patients with chronic liver diseases were assessed. We studied 738 patients (462 with chronic viral hepatitis, 117 with autoimmune liver diseases, 113 with alcoholic or nonalcoholic fatty liver disease, and 46 with other liver disorders) and 1,350 healthy controls (HC). Immunoglobulin A (IgA) tTGAbs were measured by enzyme-linked immunosorbent assay and a microsphere-based flow cytometric assay. Positive sera were investigated for IgA antiendomysial antibodies (EmA). IgA tTGAb-positive subjects were invited to undergo a small-intestinal biopsy and HLA-DQ allele typing. Four of 1,350 HC (0.3%) tested tTGAb+ EmA+ and underwent a biopsy (CD confirmation in all). Four of 738 liver disease patients tested tTGAbs+ EmA+ (0.54%; not statistically significant). Two were HCV infected (1.24%; not statistically significant), and two had transaminasemia of unknown origin. Forty-three patients tested tTGAbs+ EmA− (5.8%; P < 0.001 compared to HC). Inhibition experiments verified the existence of specific IgA anti-tTG reactivity. Twenty-six of 43 patients underwent a biopsy (all negative for CD). Binary logistic regression analysis revealed age (P = 0.008), cirrhosis (P = 0.004), alkaline phosphatase (P = 0.026), and antinuclear antibodies (P = 0.012) as independent risk factors for tTGAb reactivity among the patients. It was concluded that CD prevalence is the same in HC and patients with chronic liver diseases. The prevalence of tTGAbs is higher in hepatic patients compared to HC, but their specificity for CD diagnosis in this group of patients is low. tTGAbs in patients appear to be associated with the presence of autoimmunity, cirrhosis, and cholestasis, irrespective of the origin of the liver disease.

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