Pharmacodynamics of Menatetrenone and Effects on Bone Metabolism in Continuous Ambulatory Peritoneal Dialysis Patients

Prevention of osteoporosis and renal osteodystrophy are important for the long-term quality of life in dialysis patients. We examined whether administration of menatetrenone (vitamin K2) improves bone metabolism in continuous ambulatory peritoneal dialysis (CAPD) patients. Administration of a single dose of menatetrenone (15 mg) revealed that the 24-h pharmacodynamics in CAPD patients were comparable to those in control individuals. In a 12-month period of oral menatetrenone administration (45 mg/day), eight stable CAPD patients were studied for blood-bone metabolism parameters and for bone mineral content. Blood concentration of menatetrenone was detectable during the experiment period. Only at 12 months did active vitamin D3 and bone-type alkaline phosphatase (ALP) fall significantly, while total ALP rose significantly. Bone mineral density measured by dual-energy X-ray absorptiometry remained at the same level throughout the study period, suggesting that menatetrenone may protect against bone mineral loss in CAPD patients. These results show that the same dose of oral menatetrenone can be given to CAPD patients as to control individuals, and that menatetrenone can be used safely for 1 year in CAPD patients.

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Bone Quality of the Dento-Maxillofacial Complex and Osteoporosis. Opportunistic Radiographic Interpretation

10.5772/intechopen.96487 ◽

2021 ◽

Author(s):

Plauto Christopher Aranha Watanabe ◽

Giovani Antonio Rodrigues ◽

Marcelo Rodrigues Azenha ◽

Michel Campos Ribeiro ◽

Enéas de Almeida Souza Filho ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Metabolism ◽

Bone Quality ◽

Bone Mineral ◽

Panoramic Radiography ◽

Mineral Density ◽

Radiographic Findings ◽

Radiographic Interpretation ◽

Auxiliary Mechanism

Research suggests the use of different indexes on panoramic radiography as a way to assess BMD and to be able to detect changes in bone metabolism before fractures occur. Therefore, the objective of this chapter is to describe the use of these parameters as an auxiliary mechanism in the detection of low bone mineral density, as well as to characterize the radiographic findings of patients with osteoporosis.

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The Diabetic Patient on Continuous Ambulatory Peritoneal Dialysis

Peritoneal Dialysis International ◽

10.1177/089686088300301s06 ◽

1983 ◽

Vol 3 (1_suppl) ◽

pp. 16-20 ◽

Cited By ~ 5

Author(s):

C.T. Flynn

Keyword(s):

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Diabetic Patients ◽

Term Survival ◽

Basic Issue ◽

Insulin Dependent ◽

Intraperitoneal Insulin ◽

Insulin Dependent Diabetic

Insulin-dependent diabetics with renal failure have a relatively poor long-term survival. The basic issue, therefore, is quality of life. CAPD allows the patient to be independent. The procedure can be performed as well by the blind as by a sighted patient and thus is available to blind diabetics. Intraperitoneal insulin offers a safe, consistent and convenient control of the blood sugar. Our experience suggests that continuous ambulatory peritoneal dialysis is the dialytic treatment of choice for the majority of insulin-dependent diabetic patients.

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