Prophylaxis of Radiation-Induced Dermatitis in Patients With Breast Cancer Using Herbal Creams: A Prospective Randomized Controlled Trial

Radiation-induced toxicity is a major limiting factor for prescribing radiation dose in cancer radiotherapy. Skin reaction to radiation is one of the primary concerns, which could affect quality of life of the patients both physically and mentally. Reviews of the literature show limited number of effective reagents for its prophylaxis. In this study, we attempted to determine whether prophylactic treatment of the 3 different herbal creams containing Centella asiatica, Cucumis sativus, and Thunbergia laurifolia extracts as well as a commercial moisturizing cream could reduce acute skin reaction in breast cancer patients undergoing radiotherapy. A total of 153 breast cancer patients undergoing radiotherapy were randomly assigned into 5 different groups with one group receiving no treatment. The patients were instructed to apply their designated creams once daily from their first radiotherapy session until 1-month post-irradiation. Their skins were graded by a radiation oncologist on a weekly basis until 1-month post-irradiation to identify any skin reactions. The results showed that the administration of the herbal creams or the moisturizing cream could neither reduce the severity nor delay the onset of dermatitis compared with the no treatment group. However, despite the limited benefits from the prophylaxis, the Cucumis sativus cream was shown to help with the skin recovery post-irradiation. These results suggested that breast cancer patients undergoing radiotherapy should be advised to apply moisturizing cream to the area of irradiated skin.

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Efficacy Study of Mepitel Film the Prophylaxis of Radiation-Induced Skin Reactions in Breast Cancer Patients

Case Medical Research ◽

10.31525/ct1-nct03910595 ◽

2019 ◽

Author(s):

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Efficacy Study ◽

Breast Cancer Patients ◽

Skin Reactions ◽

Radiation Induced

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An evaluation of the skincare management of patients receiving radiotherapy for breast cancer

Journal of Radiotherapy in Practice ◽

10.1017/s1460396919000724 ◽

2019 ◽

Vol 19 (4) ◽

pp. 365-369 ◽

Cited By ~ 1

Author(s):

Leona McAlinden ◽

Andrea Mullan ◽

Paul Shepherd

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Best Practice ◽

Management Strategies ◽

Breast Cancer Patients ◽

Skin Reactions ◽

Prophylactic Measures ◽

Radiation Induced ◽

Guidance Needs ◽

The Uk

AbstractAim:Breast cancer patients experience skin reactions during radiotherapy. Radiation-induced skin reactions can result in treatment delivery being interrupted. The aim of this paper is to evaluate the skincare management of patients receiving radiotherapy for breast cancer in order to inform best practice.Method:A literature search was undertaken using USearch and HONNI in support of the first-hand evidence gained from the supervised on-treatment review of patients receiving radiotherapy for breast cancer.Results:There is evidence to suggest that the skincare advice given to patients varies widely between departments in the UK with many not following nationally recommended guidelines. Studies demonstrate that there are ways to reduce skin reactions and that there are a range of effective management strategies being adopted. Prophylactic skincare has been explored to improve the resilience of the skin prior to commencing radiotherapy.Findings:Further investigation is required in order to clearly establish the optimum national skincare management for breast cancer patients. More studies are required to test the effectiveness and viability of prophylactic measures. Skincare guidance needs to be robustly developed and effectively promoted by therapeutic radiographers for radiotherapy patients to benefit from reduced, radiation-induced, skin reactions.

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SU-FF-T-353: Parameters Study for the Severity Acute Radiation Induced Skin Reaction for the Breast Cancer Patients

Medical Physics ◽

10.1118/1.2241274 ◽

2006 ◽

Vol 33 (6Part12) ◽

pp. 2127-2127

Author(s):

M Su ◽

C Torres ◽

D Grant ◽

T Kim ◽

D Papadopoulos

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Skin Reaction ◽

Acute Radiation ◽

Breast Cancer Patients ◽

Radiation Induced

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An investigation into the use of a non-metallic deodorant during radiotherapy treatment: a randomised controlled trial

Journal of Radiotherapy in Practice ◽

10.1017/s146039690800647x ◽

2009 ◽

Vol 8 (1) ◽

pp. 3-9 ◽

Cited By ~ 21

Author(s):

Claire Bennett

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Controlled Trial ◽

Daily Routine ◽

Breast Cancer Patients ◽

Skin Reactions ◽

The United Kingdom ◽

Patient Groups ◽

Group 2 ◽

Randomised Controlled

AbstractIntroduction: Many patients in the United Kingdom having radiotherapy for breast cancer are recommended not to use a deodorant during treatment. The advice is not evidence based, it is solely thought as deodorants contained metals, which would react with radiation and cause an increased skin reaction. Hence this research was undertaken to establish whether patients having a course of radiotherapy for breast cancer could use a deodorant as part of their daily routine.Method: The research took place between May 2004 and February 2005. A total of 192 breast cancer patients were recruited. This included breast or chest-wall patients with or without axilla involvement. The study was designed with two groups. Group 1 used no deodorant and Group 2 a specific deodorant. The researcher reviewed patients weekly, assessing skin reactions and recording the researcher and patient's observations.Results: Most patients experienced no reaction or mild erythema and dry desquamation in the axilla. This was observed in both groups. Therefore, findings of this study indicate that future breast cancer patients should be given the choice of using this deodorant.Further recommendations: Test the reliability of the skin assessment form, extend the research to include other patient groups who have their axilla treated, test different deodorants.

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Radiation-induced DNA damage and repair in lymphocytes from breast cancer patients and their correlation with acute skin reactions to radiotherapy

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/s0360-3016(02)04415-2 ◽

2003 ◽

Vol 55 (5) ◽

pp. 1216-1225 ◽

Cited By ~ 57

Author(s):

Odilia Popanda ◽

Reinhard Ebbeler ◽

Dorothee Twardella ◽

Irmgard Helmbold ◽

Florian Gotzes ◽

...

Keyword(s):

Breast Cancer ◽

Dna Damage ◽

Cancer Patients ◽

Breast Cancer Patients ◽

Skin Reactions ◽

Dna Damage And Repair ◽

Acute Skin Reactions ◽

Radiation Induced

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Radiation-induced stress response in peripheral blood of breast cancer patients differs between patients with severe acute skin reactions and patients with no side effects to radiotherapy

Mutation Research/Genetic Toxicology and Environmental Mutagenesis ◽

10.1016/j.mrgentox.2013.04.014 ◽

2013 ◽

Vol 756 (1-2) ◽

pp. 152-157 ◽

Cited By ~ 20

Author(s):

Sara Skiöld ◽

Ingemar Naslund ◽

Karl Brehwens ◽

Arja Andersson ◽

Peter Wersall ◽

...

Keyword(s):

Breast Cancer ◽

Stress Response ◽

Side Effects ◽

Cancer Patients ◽

Peripheral Blood ◽

Breast Cancer Patients ◽

Skin Reactions ◽

Induced Stress ◽

Acute Skin Reactions ◽

Radiation Induced

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5124 POSTER A Phase II Randomized Controlled Trial of Manuka Honey as Prophylaxis Against Radiation-induced Dermatitis in Breast Cancer Patients

European Journal of Cancer ◽

10.1016/s0959-8049(11)71566-0 ◽

2011 ◽

Vol 47 ◽

pp. S367 ◽

Cited By ~ 1

Author(s):

N. Naidoo ◽

P. Molan ◽

R. Littler ◽

G. Mok ◽

M. Jameson ◽

...

Keyword(s):

Breast Cancer ◽

Randomized Controlled Trial ◽

Cancer Patients ◽

Phase Ii ◽

Controlled Trial ◽

Breast Cancer Patients ◽

Manuka Honey ◽

Randomized Controlled ◽

Radiation Induced

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Targeted Next-Generation Sequencing for the Identification of Genetic Predictors of Radiation-Induced Late Skin Toxicity in Breast Cancer Patients: A Preliminary Study

Journal of Personalized Medicine ◽

10.3390/jpm11100967 ◽

2021 ◽

Vol 11 (10) ◽

pp. 967

Author(s):

Sarah Cargnin ◽

Nadia Barizzone ◽

Chiara Basagni ◽

Carla Pisani ◽

Eleonora Ferrara ◽

...

Keyword(s):

Breast Cancer ◽

Next Generation Sequencing ◽

Cancer Patients ◽

Skin Toxicity ◽

Next Generation ◽

Breast Cancer Patients ◽

Skin Reactions ◽

Targeted Next Generation Sequencing ◽

Radiation Induced ◽

Generation Sequencing

Normal tissue radiosensitivity is thought to be influenced by an individual’s genetic background. However, the specific genetic variants underlying the risk of late skin reactions following radiotherapy for breast cancer remain elusive. To unravel the genetic basis for radiation-induced late skin toxicity, we carried out targeted next-generation sequencing of germline DNA samples from 48 breast cancer patients with extreme late skin toxicity phenotypes, consisting of 24 cases with grade 2–3 subcutaneous fibrosis and/or grade 2–3 telangiectasia (LENT-SOMA scales) and 24 controls with grade 0 fibrosis and grade 0 telangiectasia. In this exploratory study, a total of five single-nucleotide variants (SNVs) located in three genes (TP53, ERCC2, and LIG1) reached nominal levels of statistical significance (p < 0.05). In the replication study, which consisted of an additional 45 cases and 192 controls, none of the SNVs identified by targeted NGS achieved nominal replication. Nevertheless, TP53 rs1042522 (G > C, Pro72Arg) in the replication cohort had an effect (OR per C allele: 1.52, 95%CI: 0.82–2.83, p = 0.186) in the same direction as in the exploratory cohort (OR per C allele: 4.70, 95%CI: 1.51–14.6, p = 0.007) and was found be nominally associated to the risk of radiation-induced late skin toxicity in the overall combined cohort (OR per C allele: 1.79, 95%CI: 1.06–3.02, p = 0.028). These results raise the possibility of an association between TP53 rs1042522 and risk of radiation-induced late skin toxicity in breast cancer patients; however, large replication studies are warranted for conclusive evidence.

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