scholarly journals Current Advancements and Novel Strategies in the Treatment of Metastatic Melanoma

2021 ◽  
Vol 20 ◽  
pp. 153473542199007
Author(s):  
Siddhartha Sood ◽  
Rahul Jayachandiran ◽  
Siyaram Pandey

Melanoma is the deadliest form of skin cancer in the world with a growing incidence in North America. Contemporary treatments for melanoma include surgical resection, chemotherapy, and radiotherapy. However, apart from resection in early melanoma, the prognosis of patients using these treatments is typically poor. In the past decade, there have been significant advancements in melanoma therapies. Immunotherapies such as ipilimumab and targeted therapies such as vemurafenib have emerged as a promising option for patients as seen in both scientific and clinical research. Furthermore, combination therapies are starting to be administered in the form of polychemotherapy, polyimmunotherapy, and biochemotherapy, of which some have shown promising outcomes in relative efficacy and safety due to their multiple targets. Alongside these treatments, new research has been conducted into the evidence-based use of natural health products (NHPs) and natural compounds (NCs) on melanoma which may provide a long-term and non-toxic form of complementary therapy. Nevertheless, there is a limited consolidation of the research conducted in emerging melanoma treatments which may be useful for researchers and clinicians. Thus, this review attempts to evaluate the therapeutic efficacy of current advancements in metastatic melanoma treatment by surveying new research into the molecular and cellular basis of treatments along with their clinical efficacy. In addition, this review aims to elucidate novel strategies that are currently being used and have the potential to be used in the future.

2020 ◽  
Vol 16 (1) ◽  
pp. 45-55
Author(s):  
Dalya Abdulla

Background: Understanding patterns and drivers for natural health product (NHP) usage among immigrants is essential in the provision of appropriate health care; many studies have elucidated NHP utilization among immigrants; however, few have considered impacts of concurrent NHP and prescription medication usage. Objective: The study aims to determine new immigrant NHP usage patterns (including concurrent usage with prescription medications) and to discern economic impacts driving concurrent usage. Methods: A survey questionnaire was administered to local new immigrants during English Language Training classes. Results: Most participants understood the NHP definition and would take an NHP for the same disease or condition they would normally take a prescription medication for. Many participants agreed that NHPs are not safe however were unable to provide robust examples of unsafe NHP usage. With regard to purchases of medicines for short and long term illnesses, a high percentage of participants would purchase the prescription medication for a short term illness over the NHP; however this percentage decreases in the event of a long term illness, with more participants relying on NHPs to remedy their long term illness symptoms. Conclusion: Pharmacoeconomics tends to be a major driver for immigrant utilization of NHPs, and is a stronger influencer of use compared to ethnicity or parenteral usage of such products. This pharmacoeconomic correlation in the preference to use NHPs over prescription medications tends to be more observable for chronic and long term conditions (compared to short term illnesses).


2004 ◽  
Vol 38 (9) ◽  
pp. 1406-1411 ◽  
Author(s):  
Mário L de Lemos ◽  
Leela John ◽  
Lynne Nakashima ◽  
Robin K O'Brien ◽  
Suzanne CM Taylor

2011 ◽  
Vol 13 (1) ◽  
pp. 102 ◽  
Author(s):  
Sarah Khalifé ◽  
Muhammad Zafarullah

2021 ◽  
Author(s):  
◽  
Jiang Chang

<p>The rise of global consumption, as well as technological innovation in transportation and telecommunications, have increased international exchange of goods, services and factors of production. Economic globalization in terms of production and markets has been accompanied by an unprecedented intensification of economic and financial linkages within geographic regions. The world economy is shifting towards greater regional economic integration. As open and dynamic economies, New Zealand and China heavily rely on international trade and investment to stimulate economic growth. Strengthened international linkages and improved access to markets are major economic strategies for both countries. As they have been committed to building up longstanding and healthy bilateral trade and economic partnerships, these two countries signed a free trade agreement (FTA) that aims to liberalize and facilitate trade in goods, services and investment, and improve the business environment and strengthen cooperation in a wide range of economic areas. From the perspective of New Zealand's businesses, the FTA will not only improve the business environment, and open up market access opportunities, but it will also pose threats. To take advantage of these opportunities, neutralize threats, and consequently achieve a stronger market position in the Chinese marketplace, New Zealand's businesses must strategically respond to the fast-changing environment arising from the FTA. Due to the special meaning of the FTA to New Zealand's economic growth and the significance of the Chinese market to New Zealand's businesses operating in China, it is important to explore how New Zealand's firms perceive the New Zealand-China FTA; and what strategic decisions and adjustments they have made or they are going to make in response to shifts in the business environment arising from the FTA. Besides several studies with limited empirical evidence were conducted at the macro-economic level by some of interested groups such as New Zealand Ministry of Foreign Affairs and Trade during the FTA negotiations, little research has been conducted to examine the impact of the New Zealand-China FTA on New Zealand individual companies' business strategic performance. Building on case studies of two representative companies in the New Zealand natural health products industry, this study aims to discover the nature of salient companies under the New Zealand-China FTA and to ascertain what particular patterns of strategy and performance these companies will adopt in response to trade liberalization. The findings of this study suggest that: 1) With the New Zealand-China FTA, the Chinese fast-growing market is typical of the mix of the opportunities and challenges facing New Zealand's businesses. The FTA provides them with a strong incentive to undertake strategic adjustments for further development in the Chinese market. 2) Strategic adjustments made by a firm depend upon the nature of its firm-specific advantages and country-specific advantages, as well as its existing competitive advantages. Firms that are able to secure their resources and capabilities necessary to exploit opportunities and counter threats are more likely to gain international competitive advantages; 3) Small firms with limited resources and capabilities are more likely to engage in the formation of strategic alliances in order to strengthen their competitive positions both domestically and internationally.</p>


OCL ◽  
2019 ◽  
Vol 26 ◽  
pp. 29 ◽  
Author(s):  
Nada Hladni ◽  
Dragana Miladinović

Growing confectionery sunflower for consumption is becoming more and more attractive in the whole world. In Eastern European countries production, processing, and breeding of confectionery sunflower differ from oil-type sunflower. There is no precise information on the sowing areas of confectionery varieties and hybrids in Eastern European countries, mostly because, in statistical reports, sunflower producers do not provide separate data on the share of varieties in gross revenue of all manufactured products. Confectionery sunflower seeds are used in bakery products, but also in a number of natural health products and healthy snacks, as well as for direct consumption in the hull, dehulled, raw or backed form. Confectionery sunflower breeding is characterized by the fact that different markets have different demands when it comes to the seed size, hull colour, and other traits, which make this process more difficult and costlier. Market demands and production area of confectionery sunflower show a steady increase due to its nutritional value and use in human nutrition. In Eastern European countries, it is expected that the highly productive confectionery hybrids will replace varieties, which will lead to the increase of surfaces under this crop.


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