Aims: Social context is an important factor in determining the developmental trajectory of alcohol use. We examined the co-development between alcohol use problems and antisocial peer affiliation in a longitudinal sample of twins from the United States mid-west region, beginning prior to alcohol initiation and extending across key developmental periods in the natural history of alcohol use (ages 11-34). Methods: Bivariate latent basis models with structured residuals (LBM-SR) were used to estimate between- and within- person effects of self-report alcohol use problems and self-report antisocial peer affiliation. We also estimated the genetic and environmental influences on alcohol use problems, antisocial peer affiliation, and their co-development over time.Results: The LBM-SR model revealed that there was a large correlation between the growth factors for alcohol use problems and antisocial peer affiliation (r = .78, 95% Confidence Interval [CI]: .76, ,80) and cross-lagged effects consistent with both selection and socialization effects. Additionally, antisocial peer affiliation in adolescence was associated with greater increases in alcohol use problems over time (r = .57, 95% CI: .54, .60). Genetic influences largely accounted for the association between antisocial peer affiliation in pre-adolescence and growth in alcohol use problems, while shared environmental influences accounted for the correlation between antisocial peer affiliation and alcohol use problems growth factors.Conclusions: This is the first study to examine the co-development of alcohol use problems and antisocial peer affiliation and their shared genetic and environmental influences from adolescence into adulthood. Findings demonstrate that antisocial peer affiliation in adolescence is a salient, genetically-influenced risk factor for early alcohol use and increase in alcohol use from adolescence through young adulthood. These findings have implications for the development of interventions to target “high-risk” children before the onset of alcohol use.