scholarly journals The Role of MSX1 in Human Tooth Agenesis

2002 ◽  
Vol 81 (4) ◽  
pp. 274-278 ◽  
Author(s):  
A.C. Lidral ◽  
B.C. Reising
Keyword(s):  
Human Tooth ◽  
Tooth Agenesis

51 VARIATIONS IN MSX1 AND PAX9 ARE ASSOCIATED WITH HUMAN TOOTH AGENESIS

2005 ◽  
Vol 53 (2) ◽  
pp. S395.6-S396
Author(s):  
S. A. Frazier-Bowers ◽  
M. A. Torain ◽  
J. T. Wright
Keyword(s):  
Human Tooth ◽  
Tooth Agenesis

Further evidence for the role of WNT10A, WNT10B and GREM2 as candidate genes for isolated tooth agenesis

2018 ◽  
Vol 21 (4) ◽  
pp. 258-263 ◽  
Author(s):  
Sonia Magruder ◽  
Emily Carter ◽  
Meredith A. Williams ◽  
Jeryl English ◽  
Sercan Akyalcin ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Tooth Agenesis

The molecular basis of non-syndromic orofacial clefts and tooth agenesis

2018 ◽  
Vol 86 (4) ◽  
pp. 321
Author(s):  
Agnieszka Danuta Gaczkowska ◽  
Paweł Piotr Jagodziński ◽  
Adrianna Mostowska
Keyword(s):  
Genetic Factors ◽  
Tooth Agenesis ◽  
Chromosomal Locus ◽  
Orofacial Clefts ◽  
Factors Influencing ◽  
Polymorphic Variants ◽  
Methodological Approaches ◽  
Genetic And Environmental Factors ◽  
European Populations

Non-syndromic orofacial clefts and tooth agenesis are two of the most common craniofacial birth defects. Both of them have a complex etiology, with genetic and environmental factors involved. Additionally, the epigenetic modifications have been implicated in the pathogenesis of these structural malformations. Despite an increasing number of research studies, using a variety of methodological approaches, the role of genetic factors in the etiology of orofacial clefts and tooth agenesis is still not well elucidated. The most consistent findings across studies concerning the genetic factors influencing the risk to orofacial clefts include the association of polymorphic variants of the IRF6 gene and the chromosomal locus 8q24.21. The major candidate gene for tooth agenesis in the European populations is WNT10A; its pathogenic mutations are present in more than 50% of patients with this dental anomaly. It has been found that both orofacial clefts and tooth agenesis, which co-occurrence is often reported, may share common candidate genes.

scholarly journals On the vital role of enamel prism interfaces and graded properties in human tooth survival

2020 ◽  
Vol 16 (8) ◽  
pp. 20200498
Author(s):  
Oscar Borrero-Lopez ◽  
Paul J. Constantino ◽  
Mark B. Bush ◽  
Brian R. Lawn
Keyword(s):  
Longitudinal Crack ◽  
Element Model ◽  
Vital Role ◽  
Human Tooth ◽  
Extended Finite Element ◽  
Enamel Microstructure ◽  
Human Enamel ◽  
Tooth Survival ◽  
Indentation Experiment

Teeth of omnivores face a formidable evolutionary challenge: how to protect against fracture and abrasive wear caused by the wide variety of foods they process. It is hypothesized that this challenge is met in part by adaptations in enamel microstructure. The low-crowned teeth of humans and some other omnivorous mammals exhibit multiple fissures running longitudinally along the outer enamel walls, yet remain intact. It is proposed that inter-prism weakness and enamel property gradation act together to avert entry of these fissures into vulnerable inner tooth regions and, at the same time, confer wear resistance at the occlusal surface. A simple indentation experiment is employed to quantify crack paths and energetics in human enamel, and an extended-finite-element model to evaluate longitudinal crack growth histories. Consideration is given as to how tooth microstructure may have played a vital role in human evolution, and, by extension, to other omnivorous mammals.

The role of osteonectin in human tooth development: An immunohistological study

1992 ◽  
Vol 50 (5) ◽  
pp. 468-472 ◽  
Author(s):  
T. Reichert ◽  
S. St�rkel ◽  
K. Becker ◽  
L. W. Fisher
Keyword(s):  
Tooth Development ◽  
Human Tooth ◽  
Immunohistological Study

The role of MSX1 in tooth agenesis in Iranians

2007 ◽  
Vol 17 (4) ◽  
pp. 254-258 ◽  
Author(s):  
MASSOUD SEIFI ◽  
BAHRAM KAZEMI ◽  
PARISA GOLKAR
Keyword(s):  
Tooth Agenesis

“TOOTH AGENESIS: A REVIEW OF MOLECULAR BASES”

2021 ◽  
pp. 55-60
Author(s):  
Luciani F. ◽  
Papa E. ◽  
Costantini R. ◽  
Condò R. ◽  
L. Calabrese
Keyword(s):  
Literature Review ◽  
Current Knowledge ◽  
Tooth Agenesis ◽  
Dental Anomalies ◽  
Human Race ◽  
Dental Pathology ◽  
Molecular Bases ◽  
Positive Results ◽  
State Of Art

Both recent progresses reached in molecular genetics and “Genoma Umano” project have collected positive results for the identication of those different genes involved in pathogenesis of human race pathologies. Just like any other medicine branch, dentistry could prot from molecular biology recent progresses, showing several answers to unknown questions. This knowledge also concerns genesis of pathologies interesting tissues (enamel, dentin, pulp, cementum), teeth formation and development. Our work aims at verifying, by means of a literature review, the current knowledge and the state of art of dental agenesis molecular bases, in order to better understand the etiopathogenetic role of inheritance and transmission of hypodontia. Our literature review elaborates on dental agenesis biomolecular bases, in order to group in one review all the new ndings in genetic eld about dental anomalies, attempting to give the clinician more information to make easier to manage one of the most discussed surgical dental pathology.

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