Genetic Predisposition to External Apical Root Resorption in Orthodontic Patients: Linkage of Chromosome-18 Marker

2003 ◽  
Vol 82 (5) ◽  
pp. 356-360 ◽  
Author(s):  
R.A. Al-Qawasmi ◽  
J.K. Hartsfield ◽  
E.T. Everett ◽  
L. Flury ◽  
L. Liu ◽  
...  
Keyword(s):  
Orthodontic Treatment ◽  
Root Resorption ◽  
Buccal Swab ◽  
Candidate Gene Approach ◽  
Linked Gene ◽  
Maxillary Central Incisor ◽  
Apical Root Resorption ◽  
Tnf Α ◽  
Orthodontic Patients ◽  
External Apical Root Resorption

External apical root resorption (EARR) is a common orthodontic treatment sequela. Previous studies implicate a substantial genetic component for EARR. Using a candidate gene approach, we investigated possible linkage of EARR associated with orthodontic treatment with the TNSALP, TNF α , and TNFRSF11A gene loci. The sample was comprised of 38 American Caucasian families with a total of 79 siblings who completed comprehensive orthodontic treatment. EARR was assessed by means of pre- and post-treatment radiographs. Buccal swab cells were collected for extraction and analysis of DNA. No evidence of linkage was found with EARR and the TNF α and TNSALP genes. Non-parametric sibling pair linkage analysis identified evidence of linkage (LOD = 2.5; p = 0.02) of EARR affecting the maxillary central incisor with the microsatellite marker D18S64 (tightly linked to TNFRSF11A). This indicates that the TNFRSF11A locus, or another tightly linked gene, is associated with EARR.

Outcome of orthodontic treatment in subjects with periodontal disease. Part III: a CBCT study of external apical root resorption

2019 ◽  
Vol 41 (6) ◽  
pp. 575-582 ◽  
Author(s):  
Eglė Zasčiurinskienė ◽  
Henrik Lund ◽  
Rune Lindsten ◽  
Henrik Jansson ◽  
Krister Bjerklin
Keyword(s):  
Periodontal Disease ◽  
Inclination Angle ◽  
Orthodontic Treatment ◽  
Root Resorption ◽  
Control Group ◽  
Central Incisor ◽  
Maxillary Central Incisor ◽  
Apical Root Resorption ◽  
External Apical Root Resorption ◽  
Maxillary Incisors

Summary Background No evidence is present on the risk for external apical root resorption (EARR) during orthodontic treatment (OT) of adult patients with periodontal disease. Aim To examine EARR after OT in subjects with periodontal disease and to analyse how intrusion and change in inclination of the most proclined maxillary incisors influence EARR. Methods The study included 50 patients with periodontal disease. Sub-gingival debridement by ultrasonic instrumentation supplemented with hand instruments was performed by experienced dental hygienist after baseline examination for all patients. For the control group, final periodontal treatment (PT) was performed before orthodontic tooth movement. For the test group patients, final PT was performed after levelling and alignment phases were finished, before the active space closure with elastic chain and/or inter-arch elastic traction for sagittal correction was started. OT was performed with a straight-wire appliance. Micro-implants or implants were used for posterior anchorage. Cone beam computed tomography examinations were performed before and after OT. EARR of all single-rooted teeth were measured. EARR of the most proclined maxillary incisor was related to intrusion and change in inclination angle. Results EARR after OT was observed in median 80.7 per cent (interquartile range 22.02) of single-rooted teeth [mean 1.2 (standard deviation 0.44) mm]. In 82.3 per cent of teeth, EARR was 2 mm or less. Severe EARR was found in 8 per cent of patients and five maxillary incisors (less than 1 per cent of all teeth). The amount of intrusion and change in inclination angle of the most proclined maxillary central incisor influenced the extent of EARR. Mean EARR was significantly higher when OT lasted more than 18 months (P = 0.02). Conclusions OT in conjunction with PT in periodontal patients resulted in EARR in 81 per cent of all single-rooted teeth. Intrusion and change in inclination angle of the most proclined maxillary central incisor influenced the extent of EARR, as did longer OT.

scholarly journals Analysis of correlation between initial alveolar bone density and apical root resorption after 12 months of orthodontic treatment without extraction

2014 ◽  
Vol 19 (5) ◽  
pp. 97-102 ◽  
Author(s):  
Paula Cabrini Scheibel ◽  
Adilson Luiz Ramos ◽  
Lilian Cristina Vessoni Iwaki ◽  
Kelly Regina Micheletti
Keyword(s):  
Bone Density ◽  
Orthodontic Treatment ◽  
Alveolar Bone ◽  
Root Resorption ◽  
Extraction Methods ◽  
Orthodontic Movement ◽  
Apical Root Resorption ◽  
Orthodontic Patients ◽  
External Apical Root Resorption ◽  
Periapical Radiography

OBJECTIVE: The aim of the present study was to investigate the correlation between initial alveolar bone density of upper central incisors (ABD-UI) and external apical root resorption (EARR) after 12 months of orthodontic movement in cases without extraction. METHODS: A total of 47 orthodontic patients 11 years old or older were submitted to periapical radiography of upper incisors prior to treatment (T1) and after 12 months of treatment (T2). ABD-UI and EARR were measured by means of densitometry. RESULTS: No statistically significant correlation was found between initial ABD-UI and EARR at T2 (r = 0.149; p = 0.157). CONCLUSION: Based on the present findings, alveolar density assessed through periapical radiography is not predictive of root resorption after 12 months of orthodontic treatment in cases without extraction.

scholarly journals External apical root resorption in maxillary root-filled incisors after orthodontic treatment: A split-mouth design study

2012 ◽  
pp. e523-e527 ◽  
Author(s):  
JM. Llamas-Carreras ◽  
A. Amarilla ◽  
E. Espinar-Escalona ◽  
L. Castellanos-Cosano ◽  
J. Martin-Gonzalez ◽  
...  
Keyword(s):  
Orthodontic Treatment ◽  
Root Resorption ◽  
Design Study ◽  
Apical Root Resorption ◽  
External Apical Root Resorption

scholarly journals Comparison of Apical Root Resorption encountered during Maxillary Incisor retraction using Stainless Steel Boot Loop and TMA Boot Loop – A Case Series

2016 ◽  
Vol 6 (1) ◽  
pp. 45-48
Author(s):  
Gaurav Gupta ◽  
Raj Kumar Singh ◽  
Ashima Relhan ◽  
Gurkeerat Singh ◽  
Abhishek Goyal
Keyword(s):  
Stainless Steel ◽  
Orthodontic Treatment ◽  
Root Resorption ◽  
Case Series ◽  
Maxillary Incisor ◽  
Apical Root Resorption ◽  
Incisor Retraction ◽  
External Apical Root Resorption

External apical root resorption (EARR) is probably the most common iatrogenic sequel of orthodontic treatment. The present case series focuses on the incisor retraction using frictionless mechanics. Boot loop made up of .019x.025 Stainless steel or TMA archwire were used for maxillary incisor retraction. Retraction with stainless steel boot loop showed greater root resorption as compared to TMA boot loop.Orthodontic Journal of Nepal, Vol. 6 No. 1, June 2016, pp.45-48 

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