scholarly journals The prognostic value of serum bilirubin in colorectal cancer patients with surgical resection

2021 ◽  
Vol 36 (2) ◽  
pp. 172460082110361
Author(s):  
Zhangjun Jia ◽  
Zeyu Zhu ◽  
Ying Wang ◽  
Jing Ding ◽  
Zhenzhong Lin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Surgical Resection ◽  
Total Bilirubin ◽  
Serum Bilirubin ◽  
Direct Bilirubin ◽  
Prognostic Impact ◽  
Indirect Bilirubin ◽  
Colorectal Cancer Patients

Purpose Serum bilirubin plays an important role in antioxidant and anticancer processes. The inverse association between serum bilirubin and cancer risk have been widely reported in multiple cancers. The aim of this retrospective study was to investigate the prognostic impact of serum bilirubin in colorectal cancer patients undergoing surgical resection. Methods The value of serum bilirubin including total bilirubin, direct bilirubin, and indirect bilirubin were tested at pre-operatively in 330 colorectal cancer patients. The optimal cut-off values for these three biomarkers were determined by X-tile program. The relationship between serum bilirubin and outcomes were examined using Kaplan–Meier curves log-rank test, univariate and multivariate cox regression. Moreover, a number of risk factors were used to form a nomogram for evaluating risk of survival. Results The optimal cut-off points of serum total bilirubin, direct bilirubin, and indirect bilirubin were 19.5 μmol/L, 5.0 μmol/L and 8.1 μmol/L, respectively. Elevated total bilirubin and direct bilirubin were significantly associated with overall survival in surgical colorectal cancer patients. Additionally, predictive nomogram including total bilirubin and direct bilirubin for overall survival was established for predicting overall survival in surgical colorectal cancer patients. Conclusions These findings indicated that preoperative elevated total bilirubin and direct bilirubin could be considered as independent prognostic biomarkers for poor overall survival of colorectal cancer patients.

Prognostic impact of tumor deposits in colorectal cancer with lymph nodes metastasis.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15051-e15051
Author(s):  
Fangqi Liu ◽  
Jiang Zhao ◽  
Li Yang ◽  
Ji Zhu ◽  
Ye Xu
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Classification System ◽  
Tnm Classification ◽  
Prognostic Impact ◽  
Training Cohort ◽  
Tnm System ◽  
Lymph Nodes Metastasis ◽  
Colorectal Cancer Patients

e15051 Background:The TNM classification system was widely used in managing many kinds of cancer including colorectal cancer. However, there is one undefined aspect that is the value of tumor deposits (TDs) in the condition of TDs and lymph nodes metastasis (LNM) coexisting. This research aims to clarify the prognostic impact of TDs in colorectal cancer especially for the condition of TDs combined with LNM. Methods: An analysis was performed to evaluate the prognostic significance of TDs in stage Ⅰ to Ⅳ colorectal cancer patients from 2010 to 2013 using Surveillance Epidemiology and End Results (SEER) database as a training cohort (N = 65, 537). An additional 3, 719 patients from Fudan University Shanghai Cancer Center were enrolled between 2006 and 2014 as a test cohort to validate the results. Results: TDs were observed in 6.32% of patients in training cohort and 14.7% in test cohort. A significantly reduced overall survival was observed for TDs positive in LNM positive and negative colorectal cancer patients (hazard ratio [HR], 1.65; 95% CI, 1.54 to 1.76). Further analysis combining TDs with LNM shows that there is no considerable difference in the impact on overall survival between N1 and N1c or between N1 with TDs (N1TD) and N2. The 3-year survival rate was 82.3%, 72.0%, 69.9%, 55.7%, 52.1%, 39.4% for N0, N1, N1c, N1TD, N2 and N2 with TDs (N2TD) respectively. Similar results were observed in the test cohort. Conclusions: These results support the 7th and 8th TNM system in which N1c was integrated into pathological N classification. However, LNM with positive TDs should be also considered into the TNM classification system because of the high prognostic impact of TDs, which was not mentioned in the current TNM system.

Impact of Site-Specific Metastases on Surgical Value and Survival among Metastatic Colorectal Cancer Patients

2020 ◽  
Vol 86 (3) ◽  
pp. 220-227
Author(s):  
Zhen Zong ◽  
Tai-Cheng Zhou ◽  
Fu-Xin Tang ◽  
Hua-Kai Tian ◽  
Anan Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Surgical Resection ◽  
Pulmonary Metastases ◽  
Stage Iv ◽  
Prognostic Impact ◽  
Stage Iv Colorectal Cancer ◽  
Metastatic Sites ◽  
Colorectal Cancer Patients

We aimed to explore the potential prognostic impact of the metastatic site on the management approach and prognosis of stage IV colorectal cancer patients with synchronous metastases. Synchronous metastatic colorectal cancer patients reported to the Surveillance, Epidemiology, and End Results Program database between 2010 and 2013 were included in this study. Overall survival (OS) was compared between patients with different treatment options using risk-adjusted Cox proportional hazard regression models. Overall, 17,776 patients with stage IV colorectal cancer were identified. Of these patients, 2,052 (11.5%) underwent surgical resection for tumors at both the primary and meta-static sites. Patients who underwent surgical resection of both primary and metastatic sites with liver, lung, and simultaneous liver and lung metastases had a longer median OS ( P < 0.001) than patients who underwent nonsurgical treatments. Cox regression analysis revealed that surgical resection of both primary and metastatic sites was associated with a significantly enhanced OS ( P < 0.001). Colorectal cancer patients with hepatic or pulmonary metastases, who underwent metastasectomy, even in selected patients with both hepatic and pulmonary metastases after multidisciplinary evaluation, could have a better survival benefit than patients who underwent nonsurgical treatments.

scholarly journals The prognostic impact of serum bilirubin in stage IV colorectal cancer patients

2017 ◽  
Vol 32 (2) ◽  
pp. e22272 ◽  
Author(s):  
Lin Yang ◽  
Lu-Yao Ge ◽  
Ting Yu ◽  
Yan Liang ◽  
Ying Yin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Serum Bilirubin ◽  
Stage Iv ◽  
Prognostic Impact ◽  
Stage Iv Colorectal Cancer ◽  
Colorectal Cancer Patients

scholarly journals A nomogram based on pretreatment levels of serum bilirubin and total bile acid levels predicts survival in colorectal cancer patients

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yinghao Cao ◽  
Shenghe Deng ◽  
Lizhao Yan ◽  
Junnan Gu ◽  
Jia Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Bile Acid ◽  
Bile Acids ◽  
Cancer Patients ◽  
Serum Bilirubin ◽  
Cox Regression ◽  
Total Bile Acid ◽  
Cox Regression Analysis ◽  
Colorectal Cancer Patients

Abstract Background Serum bilirubin and total bile acid (TBA) levels have been reported to be strongly associated with the risk and prognosis of certain cancers. Here, we aimed to investigate the effects of pretreatment levels of serum bilirubin and bile acids on the prognosis of patients with colorectal cancer (CRC). Methods A retrospective cohort of 1474 patients with CRC who underwent surgical resection between January 2015 and December 2017 was included in the study. Survival analysis was used to evaluate the predictive value of pretreatment levels of bilirubin and bile acids. X-Tile software was used to identify optimal cut-off values for total bilirubin (TBIL), direct bilirubin (DBIL) and TBA in terms of overall survival (OS) and disease-free survival (DFS). Results DBIL, TBIL, and TBA were validated as significant prognostic factors by univariate Cox regression analysis for both 3-year OS and DFS. Multivariate Cox regression analyses confirmed that high DBIL, TBIL and TBA levels were independent prognostic factors for both OS (HR: 0.435, 95% CI: 0.299–0.637, P < 0.001; HR: 0.436, 95% CI: 0.329–0.578, P < 0.001; HR: 0.206, 95% CI: 0.124–0.341, P < 0.001, respectively) and DFS (HR: 0.583, 95% CI: 0.391–0.871, P = 0.008; HR:0.437,95% CI: 0.292–0.655, P <0.001; HR: 0.634, 95% CI: 0.465–0.865, P = 0.004, respectively). In addition, nomograms for OS and DFS were established according to all significant factors, and the c-indexes were 0.819 (95% CI: 0.806–0.832) and 0.835 (95% CI: 0.822–0.849), respectively. Conclusions TBIL, DBIL and TBA levels are independent prognostic factors in colorectal cancer patients. The nomograms based on OS and DFS can be used as a practical model for evaluating the prognosis of CRC patients.

scholarly journals PIK3CAandTP53mutations predict overall survival of stage II/III colorectal cancer patients

2018 ◽  
Vol 24 (5) ◽  
pp. 631-640 ◽  
Author(s):  
A-Jian Li ◽  
Hua-Guang Li ◽  
Er-Jiang Tang ◽  
Wei Wu ◽  
Ying Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Stage Ii ◽  
Colorectal Cancer Patients
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