Chromogranin a Measurement in Neuroendocrine Tumors

1998 ◽  
Vol 13 (1) ◽  
pp. 3-9 ◽  
Author(s):  
L. Ferrari ◽  
E. Seregni ◽  
A. Martinetti ◽  
B Van Graafeiland ◽  
S. Nerini-Molteni ◽  
...  
Keyword(s):  
Tumor Marker ◽  
Neuroendocrine Tumors ◽  
Chromogranin A ◽  
High Sensitivity ◽  
Biologically Active ◽  
Proliferative Index ◽  
Favorable Prognosis ◽  
Blood Marker ◽  
Active Substances

Neuroendocrine tumors (NETs) are rare neoplasms characterized by a low proliferative index and, in some cases, a favorable prognosis. These tumors often overproduce and release biologically active substances that are responsible for severe syndromes. Tumor marker measurement provides the clinician with useful information for the management of NET patients. The substances released by overproducing tumors are currently used as biomarkers, but there is a need for sensitive markers also for the “biochemically silent” NETs. The most effective and reliable blood marker available today is chromogranin A (CgA). Because of its high sensitivity and specificity, this glycoprotein can be used for the diagnosis, prognosis and follow-up of NETs. Furthermore, CgA measurement can be used for monitoring those tumors not overproducing or releasing any hormones or biological amines. This paper is a synthetic review on the value of CgA in NET management and reports our experiences with CgA measurement in NET patients.

scholarly journals CLINICAL VALUE OF BIOCHEMICAL MARKERS OF NEUROENDOCRINE TUMORS

2019 ◽  
Vol 19 (1S) ◽  
pp. 28-29
Author(s):  
N V Lyubimova ◽  
Yu S Timofeev ◽  
M G Toms ◽  
T Yu Kharitidi ◽  
O I Vashketova ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Biochemical Markers ◽  
Chromogranin A ◽  
Endocrine System ◽  
Progression Free Survival ◽  
High Sensitivity ◽  
Biologically Active ◽  
Clinical Value ◽  
Diagnostic Significance

Neuroendocrine tumors (NET) is a heterogeneous group of epithelial neoplasms that develop from cells of the diffuse endocrine system and found in any organ. A distinctive feature of NET is the ability to produce various biologically active peptides and amines. Currently, the most useful markers are the universal marker chromogranin-A (CgA) and specific markers serotonin and 5-hydroxyindolylacetic acid (5-HIAA). The analysis of the clinical significance of the biochemical markers of NETs was carried out by comparative analysis of their levels in serum and urine of 339 NET patients and 66 healthy people. Determination of plasma CgA, serotonin in serum and 5-HIAA in daily urine was performed using standardized ELISA methods using the Chromogranin A ELISA kit (Dako), Serotonin ELISA and 5-HIAA ELISA (IBL) test-systems. The values of CgA, serotonin, 5-HIAA in patients with NET were significantly (p < 0.001) higher than the corresponding control values. Assessment of the diagnostic significance of CgA, taking into account the cut-off level 33 U/l (with a specificity of 98.5%), showed high sensitivity in the general NET group - 80.9%. The serial determination of the marker reflected the effect of treatment. The progression free survival in different treatment regimens for patients with NET has been associated with basal levels of CgA. The medians of serotonin and 5-HIAA levels were maximal in patients with carcinoid syndrome, significantly exceeding the corresponding values in NET patients without clinical manifestations.The data indicate the possibility of using CgA, serotonin and 5-HIAA to improve the accuracy of diagnosis, evaluation of generalization and biological activity of NETs.

Serum chromogranin A in the diagnosis and follow-up of neuroendocrine tumors of the gastroenteropancreatic tract

1992 ◽  
Vol 16 (4) ◽  
pp. 697-701 ◽  
Author(s):  
Guido Schürmann ◽  
Ulrich Raeth ◽  
Bertram Wiedenmann ◽  
Heinz Buhr ◽  
Christian Herfarth
Keyword(s):  
Neuroendocrine Tumors ◽  
Chromogranin A

Is neuron-specific enolase a useful tumor marker in the diagnosis and follow-up of patients with abdominal neuroendocrine tumors?

1995 ◽  
Vol 2 (4) ◽  
pp. 311-319
Author(s):  
U Meyer-Pannwitt ◽  
K Kummerfeldt ◽  
G Froeschle ◽  
V A Dorss ◽  
R Klapdor
Keyword(s):  
Tumor Marker ◽  
Neuroendocrine Tumors ◽  
Neuron Specific Enolase

High sensitivity of chromogranin a (CgA) as serum marker of functioning and non-functioning digestive neuroendocrine tumors

2000 ◽  
Vol 118 (4) ◽  
pp. A647
Author(s):  
Carola Severi ◽  
Stefano Angeletti ◽  
Renato Cannizzaro ◽  
Vito D. Corleto ◽  
Paola Pradella ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Chromogranin A ◽  
High Sensitivity ◽  
Serum Marker

scholarly journals On the history and some characteristics of neuroendocrine tumors of the gastrointestinal tract. Review. Part 1

2021 ◽  
pp. 60-72
Author(s):  
S. Rybakov
Keyword(s):  
Gastrointestinal Tract ◽  
Neuroendocrine Tumors ◽  
Endocrine System ◽  
Secretory Activity ◽  
Clinical Syndrome ◽  
Biologically Active ◽  
Clinical Aspects ◽  
Clinical Syndromes ◽  
Diffuse Endocrine System ◽  
Active Substances

The literature review is devoted to the analysis of numerous studies that have formed the basis for creating ideas about the diffuse endocrine system. In addition to the main endocrine glands, also there are cellular accumulations and individual cells that produce various hormones and biologically active substances. It is established that, in particular, in the organs of the gastrointestinal tract, starting from the esophagus and to the terminal parts of the large intestine, there are several types of endocrine cells with these functions. Most of them are in the pancreas, antrum of the stomach, duodenum, the initial part of the intestine, in the liver. Excessive secretory activity of these cells can cause the development of pathological clinical syndromes, characterized by the effect of the corresponding hormones. The morphological substrate of such syndromes may be tumors or diffuse hyperplasia of the corresponding cells. The author considers the pancreas as an integral part of the diffuse endocrine system, as specific endocrine functions in it perform numerous accumulations (islets of Langerhans) or individual cells. The review of the numerous neuroendocrine tumors of the gastrointestinal tract examines in detail the characteristics of some of them in historical and clinical aspects, in particular insulinoma as the most common and well-studied tumor. Glucagonoma is also considered as a neuroendocrine tumor derived from α-cells of the pancreas, is a kind of insulinoma antagonist, as it secretes an excess of the hormone glucagon, causing the development of hyperglycemic clinical syndrome in contrast to hypoglycemic, caused by insulin. It is a rare tumor and its consideration after insulinoma can be explained by the antagonistic nature of the action of hormones produced by these tumors. In the group of neuroendocrine tumors of the pancreas, glucagonoma follows the frequency of insulinoma and gastrinoma.

scholarly journals On the history and some characteristics of neuroendocrine tumors of the gastrointestinal tract. Neuroendocrine tumors of the pancreas. Part 2

2021 ◽  
pp. 70-81
Author(s):  
S. I. Rybakov
Keyword(s):  
Gastrointestinal Tract ◽  
Neuroendocrine Tumors ◽  
Endocrine System ◽  
Secretory Activity ◽  
Clinical Syndrome ◽  
Biologically Active ◽  
Clinical Aspects ◽  
Clinical Syndromes ◽  
Diffuse Endocrine System ◽  
Active Substances

The literature review presents the analysis of numerous studies that have formed the basis for creating ideas about the diffuse endocrine system,namely existence of the cellular accumulations and individual cells that produce various hormones and biologically active substances in addition to the main endocrine glands. Several types of endocrine cells with these functionshave been established, in particular, in the organs of the gastrointestinal tract, starting from the esophagus and up to the terminal parts of the large intestine. Most of them are contained in the pancreas, antrum of the stomach, duodenum, the initial part of the intestine, in the liver. Excessive secretory activity of these cells can cause the development of pathological clinical syndromes, characterized by the effects of the corresponding hormones. The tumors or diffuse hyperplasia of the corresponding cellsmay present morphological substrate of such syndromes. The author considers the pancreas as an integral part of the diffuse endocrine system, as specific endocrine functions in it perform numerous accumulations (islets of Langerhans) or individual cells. The review of the numerous neuroendocrine tumors of the gastrointestinal tract examines in detail the characteristics of some of them in historical and clinical aspects, in particular Zollinger—Ellison syndrome as the most common and well-studied tumor. Glucagonoma is also considered as a neuroendocrine tumorderived from α-cells of the pancreas, is a kind of insulinoma antagonist, as it secretes an excess of the hormone glucagon, causing the development of hyperglycemic clinical syndrome in contrast to hypoglycemic, caused by insulin. It is a rare tumor and its consideration after insulinoma can be explained by the antagonistic nature of the action of hormones produced by these tumors. In the group of neuroendocrine tumors of the pancreas, glucagonoma follows the frequency of insulinoma and gastrinoma.

Follow-up in neuroendocrine tumors: is chromogranin A the confounder?

2017 ◽  
Author(s):  
Diana Martins ◽  
Carla Baptista ◽  
Ana Velez ◽  
Fernando Macario ◽  
Francisco Carrilho
Keyword(s):  
Neuroendocrine Tumors ◽  
Chromogranin A

scholarly journals Studying Possibilities of Using Beebread in Medicine with the Follow-Up Development of a Means to Improve Immunity

2019 ◽  
Vol 23 (4) ◽  
pp. 412-417
Author(s):  
D. I. Shavrina ◽  
N. V. Nesterova ◽  
O. V. Nesterova ◽  
N. V. Birukova ◽  
A. A. Iaroshenko
Keyword(s):  
Scientific Literature ◽  
Raw Materials ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Mineral Salts ◽  
Isoleucine Leucine ◽  
Bee Bread ◽  
The Russian Federation ◽  
Active Substances

In the course of the analysis of scientific literature, the composition of the bee bread containing biologically active substances (arginine, phenylalanine, isoleucine, leucine, lysine, methionine, threonine), mineral salts, trace elements and valuable vitamins that enhance immunity was studied. The complex of reactions recommended by the State Pharmacopoeia of the Russian Federation was used to determine the main groups of biologically active substances characteristic of natural raw materials. As an object of research, bee bread was used. The raw materials were identified: amino acids, hydroxyacids, saponins, flavonoids, tannins, coumarins, pectins. This beekeeping product can be recommended for use in medicine as a perspective drug.

Serum chromogranin A levels for the diagnosis and follow-up of well-differentiated non-functioning neuroendocrine tumors

Tumor Biology ◽  
2015 ◽  
Vol 37 (3) ◽  
pp. 2863-2869 ◽  
Author(s):  
Yuejuan Cheng ◽  
Zhao Sun ◽  
Chunmei Bai ◽  
Xiaoyan Yan ◽  
Ran Qin ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Chromogranin A ◽  
Well Differentiated
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