Iodine/K2CO3-catalyzed synthesis of multisubstituted pyrrolidine-2-carboxylates via a one-pot reaction between an araldehyde, an amino acid ester, and a chalcone
Keyword(s):
One Pot
◽
A series of more than 20 multisubstituted pyrrolidine-2-carboxylates were synthesized via a one-pot cycloaddition of an araldehyde, an amino acid ester, and a chalcone catalyzed by I2/K2CO3 in tetrahydrofuran at 80 °C. The advantages of this method are readily available starting materials, mild conditions, and simple operation, and it is metal free and yields are good to excellent.
2016 ◽
Vol 302
(2)
◽
pp. 1600318
◽
Keyword(s):
1997 ◽
Vol 1
(3)
◽
pp. 233-239
◽
Keyword(s):
Chemical stability, enzymatic hydrolysis, and nasal uptake of amino acid ester prodrugs of acyclovir
2001 ◽
Vol 90
(5)
◽
pp. 615
◽
Keyword(s):