Simple, novel, and efficient synthesis of ethyl 2-(2-(1H-indol-3-yl)benzo[d]thiazol-3(2H)-yl)-2-cyanoacetate or acetate via a three-component reaction
Keyword(s):
Ethyl 2-(2-(1 H-indol-3-yl)benzo[ d]thiazol-3(2 H)-yl)-2-cyanoacetate or acetate 6a–f as a series of novel compounds were synthesized from the reactions of benzothiazole, 2-methylbenzothiazole, or 2,5-dimethylbenzothiazole and ethyl bromocyanoacetate with indole derivatives. The reactions proceeded in acetone as a solvent under reflux for 5 h in good yields. The structures of new compounds were confirmed by 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, infrared, elemental analyses, and mass spectroscopy.
1972 ◽
pp. 2419
◽
1981 ◽
Vol 256
(7)
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pp. 3428-3432
1981 ◽
Vol 256
(14)
◽
pp. 7129-7138
1973 ◽
pp. 455
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