scholarly journals Changes in biochemical tests in pregnancy and their clinical significance

2018 ◽  
Vol 11 (4) ◽  
pp. 160-170 ◽  
Author(s):  
Stephanie Teasdale ◽  
Adam Morton
Keyword(s):  
Normal Pregnancy ◽  
Reference Intervals ◽  
Pathological State ◽  
Physiological Changes ◽  
Biochemical Tests ◽  
Biochemical Assays ◽  
Common Causes ◽  
Laboratory Investigations ◽  
Physiological Changes In Pregnancy ◽  
In Pregnancy

Interpretation of laboratory investigations relies on reference intervals. Physiological changes in pregnancy may result in significant changes in normal values for many biochemical assays, and as such results may be misinterpreted as abnormal or mask a pathological state. The aims of this review are as follows: 1. To review the major physiological changes in biochemical tests in normal pregnancy. 2. To outline where these physiological changes are important in interpreting laboratory investigations in pregnancy. 3. To document the most common causes of abnormalities in biochemical tests in pregnancy, as well as important pregnancy-specific causes.

scholarly journals Evaluation of physiological changes and therapeutic approaches of hypertension in pregnancy

2020 ◽  
Vol 9 (6) ◽  
pp. 01-12
Author(s):  
Mohammed Safi Ur- Rahman ◽  
Sumayya ◽  
Ayesha Naseer ◽  
Korapati Ramarao ◽  
P Srinivas Nayak
Keyword(s):  
Normal Pregnancy ◽  
Physiological Changes ◽  
Therapeutic Approaches ◽  
Pregnancy Hypertension ◽  
Hypertension In Pregnancy ◽  
Pharmacokinetic Properties ◽  
Changes In Pregnancy ◽  
Basic Concepts ◽  
Physiological Changes In Pregnancy ◽  
In Pregnancy

There are various physiological and pharmacokinetic changes occur in pregnancy to nurture the developing foetus, avoid toxicities, resistance to infections and prepare the mother for labour and delivery. Some of these changes influence normal biochemical values while others may mimic symptoms of medical disease and alter the kinetic parameters of the drugs. It is important to differentiate between normal physiological changes and disease pathology. This article highlights the important changes that take place during normal pregnancy, development of common conditions and pharmacokinetic variations. This review also will describe basic concepts in pharmacokinetics and their clinical relevance and highlight the variations in pregnancy that may impact the pharmacokinetic properties of medications, different treatment approaches, contraindications and drugs used in pregnancy Key words: Physiological changes in pregnancy, Hypertension, pregnancy disorders.

Renal disease in pregnancy

1989 ◽  
Vol 1 (2) ◽  
pp. 177-192 ◽  
Author(s):  
Priscilla Kincaid-Smith ◽  
Kenneth Fairley
Keyword(s):  
Glomerular Filtration Rate ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
First Trimester ◽  
Normal Pregnancy ◽  
Intimate Relationship ◽  
Physiological Changes ◽  
Anatomical Changes ◽  
The Right ◽  
In Pregnancy

There is an intimate relationship between the kidney and pregnancy. Renal plasma flow increases by 50–70% during a normal pregnancy and the glomerular filtration rate by about 50%.1These changes commence in the first trimester and fall in the last trimester reaching normal levels within about four weeks postpartum. These physiological changes are accompanied by striking anatomical changes which consist of dilatation of the ureter, pelvis and calyces, together with an increase in renal parenchymal size. The dilatation i s more marked on the right and may appear in the first trimester. At term, 90% of pregnant women show this change.2

scholarly journals Hyperlipidemia in pregnancy

2011 ◽  
Vol 152 (19) ◽  
pp. 753-757 ◽  
Author(s):  
Tatjána Ábel ◽  
Anna Blázovics ◽  
Márta Kemény ◽  
Gabriella Lengyel
Keyword(s):  
Cardiovascular Disease ◽  
Acute Pancreatitis ◽  
Cohort Studies ◽  
Pregnant Women ◽  
Breast Feeding ◽  
Normal Pregnancy ◽  
Large Cohort ◽  
Physiological Changes ◽  
Teratogenic Effects ◽  
In Pregnancy

Physiological changes in lipoprotein levels occur in normal pregnancy. Women with hyperlipoproteinemia are advised to discontinue statins, fibrates already when they consider pregnancy up to and including breast-feeding the newborn, because of the fear for teratogenic effects. Hypertriglyceridemia in pregnancy can rarely lead to acute pancreatitis. Management of acute pancreatitis in pregnant women is similar to that used in non-pregnant patients. Further large cohort studies are needed to estimate the consequence of supraphysiologic hyperlipoproteinemia or extreme hyperlipoproteinemia in pregnancy on the risk for cardiovascular disease later in life. Orv. Hetil., 2011, 152, 753–757.

Heart disease in pregnancy

2012 ◽  
Keyword(s):  
Heart Disease ◽  
Heart Valves ◽  
Mechanical Heart Valves ◽  
Physiological Changes ◽  
Basic Principles ◽  
Changes In Pregnancy ◽  
Physiological Changes In Pregnancy ◽  
Heart Disease In Pregnancy ◽  
Valve Lesions ◽  
In Pregnancy

Basic principles 674Physiological changes in pregnancy 676Normal findings in pregnancy 678General considerations in pregnancy 680Pulmonary hypertension and pregnancy 682Marfan syndrome and pregnancy 683Valvular heart disease in pregnancy 684Mitral stenosis and pregnancy 686Other valve lesions 687Mechanical heart valves in pregnancy ...

Pregnancy changes and early pregnancy complications

2016 ◽  
Author(s):  
Stergios K. Doumouchtsis ◽  
S. Arulkumaran ◽  
S. Arulkumaran ◽  
Edwin Chandraharan ◽  
Christina Coroyannakis ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Early Pregnancy ◽  
Pregnancy Complications ◽  
Gestational Trophoblastic Disease ◽  
Metabolic Changes ◽  
Physiological Changes ◽  
Trophoblastic Disease ◽  
Changes In Pregnancy ◽  
Physiological Changes In Pregnancy ◽  
In Pregnancy

This chapter discusses pregnancy changes and early pregnancy complications. It includes physiological changes in pregnancy (cardiovascular, haematological, respiratory, renal and urinary tract, and metabolic changes), gestational trophoblastic disease (GTD), and nausea and vomiting.

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