Childhood diabetes

2017 ◽  
Vol 10 (12) ◽  
pp. 713-720
Author(s):  
Fatima A Telford
Keyword(s):  
Type 2 Diabetes ◽  
Maturity Onset Diabetes ◽  
Coordination Of Care ◽  
Newly Diagnosed ◽  
Childhood Diabetes ◽  
Common Chronic Disease ◽  
Good Advice ◽  
The Uk

There are 31 500 children in the UK with diabetes, the second-most-common chronic disease in childhood, after asthma. Most have type 1 diabetes, those remaining have type 2 diabetes, maturity onset diabetes of the young, or cystic-fibrosis-related diabetes. About 25% of newly diagnosed children present with diabetic ketoacidosis. The NHS spends about £1 000 000 per hour on diabetes and GPs have a central role in early diagnosis, prevention of complications, prompt referral and coordination of care. Engagement with good advice and support is essential for young people with diabetes and their families. This article gives an overview of the management of childhood diabetes.

Current prevalence of Type 1 and Type 2 diabetes in adults and children in the UK

2015 ◽  
Vol 32 (9) ◽  
pp. 1119-1120 ◽  
Author(s):  
N. Holman ◽  
B. Young ◽  
R. Gadsby
Keyword(s):  
Type 2 Diabetes ◽  
Current Prevalence ◽  
Adults And Children ◽  
The Uk

scholarly journals 21-Year-Old Pregnant Woman with MODY-5 Diabetes

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Anastasia Mikuscheva ◽  
Elliot McKenzie ◽  
Adel Mekhail
Keyword(s):  
Type 2 Diabetes ◽  
Pregnant Woman ◽  
Correct Diagnosis ◽  
Monogenic Diabetes ◽  
Maturity Onset Diabetes ◽  
Renal Anomalies ◽  
Family History Of Diabetes ◽  
History Of

The term “Maturity-Onset Diabetes of the Young” (MODY) was first described in 1976 and is currently referred to as monogenic diabetes. There are 14 known entities accounting for 1-2% of diabetes and they are frequently misdiagnosed as either type 1 or type 2 diabetes. MODY-5 is an entity of monogenic diabetes that is associated with genitourinary malformations and should be considered by obstetricians in pregnant women with a screen positive for diabetes, genitourinary malformations, and fetal renal anomalies. Correct diagnosis of monogenic diabetes has implications on managing patients and their families. We are reporting a case of a 21-year-old pregnant woman with a bicornuate uterus, fetal renal anomalies, and a family history of diabetes that were suggestive of a MODY-5 diabetes.

Maturity onset diabetes of youth (MODY) in Turkish children: sequence analysis of 11 causative genes by next generation sequencing

2016 ◽  
Vol 29 (4) ◽  
Author(s):  
Sebahat Yılmaz Ağladıoğlu ◽  
Zehra Aycan ◽  
Semra Çetinkaya ◽  
Veysel Nijat Baş ◽  
Aşan Önder ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Next Generation Sequencing ◽  
Point Mutations ◽  
Maturity Onset Diabetes ◽  
Turkish Children ◽  
Onset Diabetes ◽  
Molecular Studies ◽  
Generation Sequencing

AbstractMaturity-onset diabetes of the youth (MODY), is a genetically and clinically heterogeneous group of diseasesand is often misdiagnosed as type 1 or type 2 diabetes. The aim of this study is to investigate both novel and proven mutations of 11A panel of 11We identified 28 (65%) point mutations among 43 patients. Eighteen patients haveThis is the first study including molecular studies of 11

scholarly journals Newly diagnosed type 2 diabetes in an ethnic minority population: clinical presentation and comparison to other populations

2018 ◽  
Vol 6 (1) ◽  
pp. e000568 ◽  
Author(s):  
Michael Morkos ◽  
Bettina Tahsin ◽  
Louis Fogg ◽  
Leon Fogelfeld
Keyword(s):  
Type 2 Diabetes ◽  
Ethnic Minority ◽  
Diabetes Complications ◽  
Clinical Presentation ◽  
Microvascular Complications ◽  
Macrovascular Complications ◽  
Minority Population ◽  
Newly Diagnosed ◽  
The Uk

ObjectiveTo characterize the clinical presentation of newly diagnosed type 2 diabetes of ethnic minority adults in Chicago and compare with other populations.Research design and methodsCross-sectional study examining the data of 2280 patients newly diagnosed with type 2 diabetes treated between 2003 and 2013 in a large Chicago public healthcare system.ResultsMean age of the patients was 49±11.3 years, men 54.4%, African-Americans 48.1%, Hispanics 32.5%, unemployed 69.9%, uninsured 82.2%, English-speaking 75.1%, and body mass index was 32.8±7.4 kg/m2. Microvascular complications were present in 50.1% and macrovascular complications in 13.4%. There was a presence of either macrovascular or microvascular complications correlated with older age, hypertension, dyslipidemia, inactivity, speaking English, and being insured (p<0.01). Glycosylated hemoglobin A1c (HbA1c) at presentation did not correlate with diabetes complications. In our cohort, when compared with a diverse population in the UK and insured population in the USA, HbA1c at presentation was 10.0% (86 mmol/mol), 6.6% (49 mmol/mol), and 8.2% (66 mmol/mol); nephropathy was 22.2%, 16.7%, and 5.7%; retinopathy was 10.7%, 7.9%, and 1.4%; and neuropathy was 27.7%, and 6.7% in the UK (p<0.001). There were no significant differences between groups in the prevalence of macrovascular complications.ConclusionThese results show the vulnerability of underserved and underinsured patients for developing diabetes complications possibly related to a delayed diagnosis.

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