Acute Glucose Load, Inflammation, Oxidative Stress, Nonenzymatic Glycation, and Screening for Gestational Diabetes

2019 ◽  
pp. 193371911983177 ◽  
Author(s):  
Megan L. Jones ◽  
Irina A. Buhimschi ◽  
Guomao Zhao ◽  
Anna Bartholomew ◽  
Jordan Smith-Timms ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gestational Diabetes ◽  
Glucose Load ◽  
Nonenzymatic Glycation

scholarly journals Acute Glucose Load, Inflammation, Oxidative Stress, Nonenzymatic Glycation, and Screening for Gestational Diabetes

2020 ◽  
Vol 27 (8) ◽  
pp. 1587-1594
Author(s):  
Megan L. Jones ◽  
Irina A. Buhimschi ◽  
Guomao Zhao ◽  
Anna Bartholomew ◽  
Jordan Smith-Timms ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gestational Diabetes ◽  
Glucose Load ◽  
Nonenzymatic Glycation

scholarly journals 625: Effects of acute glucose load on inflammation, oxidative stress, and markers of non-enzymatic glycosylation in women undergoing screening for gestational diabetes

2017 ◽  
Vol 216 (1) ◽  
pp. S365-S366
Author(s):  
Megan L. Jones ◽  
Irina A. Buhimschi ◽  
Guomao Zhao ◽  
Anna Bartholomew ◽  
Jordan Smith ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gestational Diabetes ◽  
Glucose Load ◽  
Enzymatic Glycosylation

Paper of oxidative stress and placenta on the development of gestational diabetes mellitus

2014 ◽  
Author(s):  
Cristina Lopez-Tinoco ◽  
Francisco Vilchez ◽  
Francisco Visiedo ◽  
Isabel Mateo ◽  
Carmen Segundo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus

Trace elements as an oxidative stress marker in women with gestational diabetes and their neonates

2017 ◽  
Author(s):  
Georgios Boutzios ◽  
Eleni Koukoulioti ◽  
Ioannis Papoutsis ◽  
Sotirios Athanaselis ◽  
Gerasimos Tsourouflis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Gestational Diabetes ◽  
Oxidative Stress Marker ◽  
Stress Marker

1435-P: Impaired Early-Phase Suppression of Glucagon Secretion after Glucose Load Associated with Insulin Need during Pregnancy in Gestational Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1435-P
Author(s):  
ICHIRO HORIE ◽  
AI HARAGUCHI ◽  
NORIO ABIRU ◽  
ATSUSHI KAWAKAMI
Keyword(s):  
Gestational Diabetes ◽  
Early Phase ◽  
Glucagon Secretion ◽  
Glucose Load

Comparison of Salivary Antioxidants and Oxidative Stress Status in Gestational Diabetes Mellitus and Healthy Pregnant Women

2020 ◽  
Vol 20 ◽  
Author(s):  
Fatemeh Ahmadi-Motamayel ◽  
Shima Fathi ◽  
Mohammad Taghi Goodarzi ◽  
Shiva Borzouei ◽  
Jalal Poorolajal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
Oxidative Stress Markers ◽  
Blood Samples ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Total Oxidative Stress ◽  
And Oxidative Stress

Background: One of the most common complications of pregnant women is gestational diabetes mellitus (GDM). Oxidative stress can play an important role in GDM. Objective: The aim of this study was to evaluate salivary antioxidants and oxidative stress markers in GDM. Method: Twenty pregnant women with GDM and 20 healthy pregnant women with normal blood glucose test participated in this study. Five mL of unstimulated saliva samples were collected. Spectrophotometric assay was carried out for sialochemical analysis. Stata software was used for data analysis. Results: The GDM group exhibited no significant difference in salivary total antioxidant capacity and malondialdehyde compared to the healthy control group. All of antioxidants markers, the uric acid, total antioxidant, peroxidase and catalase, decreased in GDM group that the difference of peroxidase and catalase was statistically significant. All of oxidative stress markers, the salivary malondyaldehid, total oxidative stress and total thiol, increased in GDM group. GDM group exhibited significantly higher salivary total oxidative stress levels. Conclusion: Catalase level was significantly lower and total oxidative stress was significantly higher. These two markers might have significant importance and might exhibit early changes compared to other factors in GDM. . Some of salivary antioxidants might have diagnostic, prognostic or therapeutic implications in GDM. Other studies with large sample size on salivary and blood samples need to be done to confirm this properties and salivary samples using instead of blood samples in GDM biomarkers changes.

scholarly journals Lack of Concordance between the 75-g and 100-g Glucose Load Tests for the Diagnosis of Gestational Diabetes Mellitus

2006 ◽  
Vol 52 (9) ◽  
pp. 1679-1684 ◽  
Author(s):  
Giorgio Mello ◽  
Parretti Elena ◽  
Agostino Ognibene ◽  
Riccardo Cioni ◽  
Filippo Tondi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Obstet Gynecol ◽  
American Diabetes Association ◽  
Glucose Load ◽  
Diagnostic Agreement ◽  
Substantial Impact ◽  
Maternal Fetal Medicine ◽  
Load Tests

Abstract Background: Gestational diabetes mellitus (GDM) is common and can have a substantial impact on fetal growth, birth weight, and morbidity. The American Diabetes Association recommends GDM testing with either a 3-h, 100-g glucose load (100g) (criteria according to Am J Obstet Gynecol 1982;144:768–73) or a 2-h, 75-g glucose load (75g). We investigated the comparability of the 75g and the 100g tests in the diagnosis of GDM. Methods: From January 1997 to December 1999, in 1061 consecutive Caucasian nonobese and nondiabetic pregnant women who attended the Maternal-Fetal Medicine Unit, we performed GDM testing with a 75-g load during 2 periods of pregnancy: early (16–20 weeks) and late (26–30 weeks). Because we assumed there would be few GBM cases in women with a 1-h plasma glucose <1300 mg/L in the 75g test, we did not retest these women. We retested the remaining women with possible or diagnosed GDM with a 100-g load within a week. Results: GDM was diagnosed in 41 of 227 women with the 100-g load and 15 of 227 with the 75-g load (11 concordant); the κ index was 0.21. At 26–31 weeks of pregnancy, 484 of 976 women (49.9%) underwent both tests. GDM was diagnosed in 60 of 484 woman with the 100-g load and in 26 of 484 with the 75-g load (13 concordant); the κ index was 0.18. Conclusions: Among women with possible GDM in both early and late periods of pregnancy, there was only weak diagnostic agreement between results determined with 75-g and 100-g glucose loads.

scholarly journals Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling

2020 ◽  
Author(s):  
Zhiwei Zhang ◽  
Hui Zhao ◽  
Aixia Wang
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Signaling Pathway ◽  
Hepatic Glycogen ◽  
Ampk Signaling ◽  
Tnf Α

Background: Gestational diabetes mellitus (GDM) has a high incidence rate among pregnant women. The objective of the study was to assess the effect of plant-derived oleuropein in attenuating inflammatory and oxidative stress of GDM. Methods: Oleuropein was administered to GDM mice at the doses of 5 or 10 mg/kg/day. Body weight, blood glucose, insulin and hepatic glycogen levels were recorded. To evaluate the effect of oleuropein in reducing oxidative stress, enzyme-linked immunosorbent assay (ELISA) was used to measure the hepatic oxidative stress markers. The inflammation levels of GDM mice were evaluated by measuring serum levels of IL-6 and TNF-α by ELISA, and mRNA levels of IL-1β, TNF-α and IL-6 by real-time PCR (RT-PCR). The AMP-activated protein kinase (AMPK) signaling pathway was assessed by Western blot. Gestational outcome was analyzed through comparing litter size and birth weight. Results: Oleuropein attenuated the elevated body weight of GDM mice, and efficiently reduced blood glucose, insulin and hepatic glycogen levels. Oxidative stress and inflammation were alleviated by oleuropein treatment. The AMPK signaling was activated by oleuropein in GDM mice. Gestational outcome was markedly improved by oleuropein treatment. Conclusions: Our study suggests that oleuropein is effective in alleviating symptoms of GDM and improving gestational outcome in the mouse model. This effect is achieved by attenuating oxidative stress and inflammation, which is mediated by the activation of the AMPK signaling pathway.

The Role of Oxidative Stress in the Pathophysiology of Gestational Diabetes Mellitus

2011 ◽  
Vol 15 (12) ◽  
pp. 3061-3100 ◽  
Author(s):  
Martha Lappas ◽  
Ursula Hiden ◽  
Gernot Desoye ◽  
Julia Froehlich ◽  
Sylvie Hauguel-de Mouzon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus
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