Paper of oxidative stress and placenta on the development of gestational diabetes mellitus

Background: Gestational diabetes mellitus (GDM) has a high incidence rate among pregnant women. The objective of the study was to assess the effect of plant-derived oleuropein in attenuating inflammatory and oxidative stress of GDM. Methods: Oleuropein was administered to GDM mice at the doses of 5 or 10 mg/kg/day. Body weight, blood glucose, insulin and hepatic glycogen levels were recorded. To evaluate the effect of oleuropein in reducing oxidative stress, enzyme-linked immunosorbent assay (ELISA) was used to measure the hepatic oxidative stress markers. The inflammation levels of GDM mice were evaluated by measuring serum levels of IL-6 and TNF-α by ELISA, and mRNA levels of IL-1β, TNF-α and IL-6 by real-time PCR (RT-PCR). The AMP-activated protein kinase (AMPK) signaling pathway was assessed by Western blot. Gestational outcome was analyzed through comparing litter size and birth weight. Results: Oleuropein attenuated the elevated body weight of GDM mice, and efficiently reduced blood glucose, insulin and hepatic glycogen levels. Oxidative stress and inflammation were alleviated by oleuropein treatment. The AMPK signaling was activated by oleuropein in GDM mice. Gestational outcome was markedly improved by oleuropein treatment. Conclusions: Our study suggests that oleuropein is effective in alleviating symptoms of GDM and improving gestational outcome in the mouse model. This effect is achieved by attenuating oxidative stress and inflammation, which is mediated by the activation of the AMPK signaling pathway.

Download Full-text

The Role of Oxidative Stress in the Pathophysiology of Gestational Diabetes Mellitus

Antioxidants and Redox Signaling ◽

10.1089/ars.2010.3765 ◽

2011 ◽

Vol 15 (12) ◽

pp. 3061-3100 ◽

Cited By ~ 165

Author(s):

Martha Lappas ◽

Ursula Hiden ◽

Gernot Desoye ◽

Julia Froehlich ◽

Sylvie Hauguel-de Mouzon ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus

Download Full-text

Advanced glycation end products and adipocytokines and oxidative stress in placental tissues of pregnant women with gestational diabetes mellitus

Experimental and Therapeutic Medicine ◽

10.3892/etm.2019.7623 ◽

2019 ◽

Author(s):

Hongxia Li ◽

Aihong Dong ◽

Xiaoxia Lv

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Advanced Glycation End Products ◽

Advanced Glycation ◽

Glycation End Products ◽

End Products ◽

And Oxidative Stress

Download Full-text

Changes in Stemness Properties, Differentiation Potential, Oxidative Stress, Senescence and Mitochondrial Function in Wharton’s Jelly Stem Cells of Umbilical Cords of Mothers with Gestational Diabetes Mellitus

Stem Cell Reviews and Reports ◽

10.1007/s12015-019-9872-y ◽

2019 ◽

Vol 15 (3) ◽

pp. 415-426 ◽

Cited By ~ 4

Author(s):

Chiou-Mee Kong ◽

Arjunan Subramanian ◽

Arijit Biswas ◽

Walter Stunkel ◽

Yap-Seng Chong ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Stem Cells ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Mitochondrial Function ◽

Wharton’S Jelly ◽

Differentiation Potential ◽

Wharton's Jelly ◽

Umbilical Cords

Download Full-text

TLR4/NF-κB Signaling Pathway Participates in the Protective Effects of Apocynin on Gestational Diabetes Mellitus Induced Placental Oxidative Stress and Inflammation

Reproductive Sciences ◽

10.1007/s43032-019-00078-5 ◽

2020 ◽

Vol 27 (2) ◽

pp. 722-730

Author(s):

Teng Liu ◽

Wei Zheng ◽

Linlin Wang ◽

Lin Wang ◽

Yanke Zhang

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Signaling Pathway ◽

Protective Effects ◽

Placental Oxidative Stress

Download Full-text

Altered Placental Oxidative Stress Status in Gestational Diabetes Mellitus

Placenta ◽

10.1016/s0143-4004(03)00183-8 ◽

2004 ◽

Vol 25 (1) ◽

pp. 78-84 ◽

Cited By ~ 130

Author(s):

M.T. Coughlan ◽

P.P. Vervaart ◽

M. Permezel ◽

H.M. Georgiou ◽

G.E. Rice

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Oxidative Stress Status ◽

Placental Oxidative Stress

Download Full-text

Plasma Markers of Oxidative Stress in Patients with Gestational Diabetes Mellitus in the Second and Third Trimester

Obstetrics and Gynecology International ◽

10.1155/2016/3865454 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 16

Author(s):

Hongwei Li ◽

Qian Yin ◽

Ning Li ◽

Zhenbo Ouyang ◽

Mei Zhong

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Paraoxonase 1 ◽

Third Trimester ◽

Significant Difference ◽

Markers Of Oxidative Stress ◽

Plasma Markers

Objective.To determine plasma markers of oxidative stress during the second and third trimester of pregnancy in patients with gestational diabetes mellitus (GDM).Study Design.We conducted a prospective nested case-control study involving 400 pregnant women, 22 of whom developed GDM. As control group, 30 normal pregnant women were chosen randomly. Plasma samples were analyzed for 8-iso-prostaglandin F2α(8-iso-PGF2α), advanced oxidative protein products (AOPPs), protein carbonyl (PCO), glutathione peroxidase-3 (GPX-3), and paraoxonase-1 (PON1) at 16–20 weeks, 24–28 weeks, and 32–36 weeks of gestation.Results.Compared to control subjects, the plasma levels of PCO, AOPPs, and 8-iso-PGF2αwere elevated at 16–20 weeks’ and 32–36 weeks’ gestation in GDM. There was no significant difference in PCO and 8-iso-PGF2αat 24–28 weeks in GDM. GPX-3 was statistically significantly increased at 16–20 weeks and 32–36 weeks in GDM. PON1 reduced in patients with GDM. No significant differences were found at 24–28 and 32–36 weeks between the GDM and control groups. In GDM, PCO, AOPPs, and 8-iso-PGF2αlevels were higher and GPX-3 and PON1 levels were lower in the second than the third trimester.Conclusion.Oxidation status increased in GDM, especially protein oxidation, which may contribute to the pathogenesis of GDM.

Download Full-text