scholarly journals Two New Naphthoquinone Derivatives from the Stem Bark of Callicarpa Maingayi

2012 ◽  
Vol 7 (10) ◽  
pp. 1934578X1200701
Author(s):  
Sumayah Mohammed Asiri ◽  
Khozirah Shaari ◽  
Faridah Abas ◽  
Nabil Ali Al-Mekhlafi ◽  
Nordin H. Lajis
Keyword(s):  
Cytotoxic Activity ◽  
Human Breast Cancer ◽  
2D Nmr ◽  
Stem Bark ◽  
Chloroform Fraction ◽  
Moderate Activity ◽  
Human Breast ◽  
Spectroscopic Analyses ◽  
First Time

Two new naphthoquinones designated as 3α-hydroxy-2-(2-hydroxypropan-2-yl)-9α-methoxy-2,3,3α,9α-tetra-hydronaphtho[2,3-b]furan-4,9-dione (callicarpa-quinone A, 1) and 5-hydroxy-2-(2-hydroxypropan-2-yl)naphtho[2,3-b]furan-4,9-dione (callicarpaquinone B, 2) were isolated from the chloroform fraction of Callicarpa maingayi. Three other known compounds, identified as avicequinone-C (3), wodeshiol (4) and paulownin (5), were reported for the first time from this species. The structure elucidation of compounds was established by comprehensive 1D and 2D NMR spectroscopic analyses as well as EIMS, UV and IR spectral data. Compounds 1 and 2 were tested in vitro for their cytotoxic activity against human breast cancer MCF-7cells. Compound 2 exhibited strong cytotoxic activity with an IC50 value of 1.9 ± 0.2 μM, while 1 showed moderate activity with an IC50 value of 25.0 ± 4.3 μM.

Trastuzumab‐monomethyl auristatin E conjugate exhibits potent cytotoxic activity in vitro against HER2‐positive human breast cancer

2018 ◽  
Vol 234 (3) ◽  
pp. 2693-2704 ◽  
Author(s):  
Meghdad Abdollahpour‐Alitappeh ◽  
Majid Lotfinia ◽  
Nader Bagheri ◽  
Koushan Sineh Sepehr ◽  
Mahdi Habibi‐Anbouhi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Her2 Positive

scholarly journals Chemical and Antioxidant Studies of Citrus macroptera

1970 ◽  
Vol 43 (4) ◽  
pp. 449-454 ◽  
Author(s):  
Sadia A Chowdhury ◽  
M Hossain Sohrab ◽  
Bidyut K Datta ◽  
Choudhury M Hasan
Keyword(s):  
Antioxidant Activity ◽  
Methanol Extract ◽  
Radical Scavenging ◽  
Stem Bark ◽  
Free Radical Scavenging ◽  
Moderate Activity ◽  
Free Radical Scavenging Assay ◽  
First Time ◽  
Radical Scavenging Assay

Lupeol (1) and Stigmasterol (2) were isolated from the crude extracts of the stem bark of Citrus macroptera (Family: Rutaceae) for the first time. The n-hexane, dichloromethane and methanol extracts were screened in vitro for antioxidant activity using the 1, 1-diphenyl-2-picrylhydrazyl-hydrate (DPPH) free radical scavenging assay. The hot methanol extract showed potential antioxidant activity (IC50: 178.96 μg/ml) whereas the cold methanol and dichloromethane extracts showed moderate activity (IC50: 242.78 μg/ml and 255.78 μg/ml respectively). Mild antioxidant activity was observed with the n-hexane extract of the stem bark of Citrus macroptera (IC50: 422.94 μg/ml). Key words: Citrus macroptera, Rutaceae, Lupeol, Stigmasterol, Antioxidant.   doi: 10.3329/bjsir.v43i4.2235 Bangladesh J. Sci. Ind. Res. 43(4), 449-454, 2008

Bacopasaponins with cytotoxic activity against human breast cancer cells in vitro

2021 ◽  
Author(s):  
Arindam Bandyopadhyay ◽  
Saraswati Garai ◽  
Prajna Paramita Banerjee ◽  
Shelley Bhattacharya ◽  
Ansuman Chattopadhyay
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Chemical Constituents of the Marine Sponge Aaptos aaptos (Schmidt, 1864) and Their Cytotoxic Activity

2021 ◽  
Vol 16 (2) ◽  
pp. 1934578X2199334
Author(s):  
Do Thi Trang ◽  
Bui Huu Tai ◽  
Dan Thuy Hang ◽  
Pham Hai Yen ◽  
Phan Thi Thanh Huong ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Spectral Data ◽  
Absolute Configuration ◽  
Marine Sponge ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Extensive Analysis ◽  
First Time ◽  
Tddft Method ◽  
Mcf 7

Seven compounds (1-7) were isolated from the marine sponge Aaptos aaptos living in the Vietnamese sea. Their structures were determined as 2 hours, 5 H,7 H,9 H-9 S-hydroxy-imidazo[1,5- α]pyridine-1,3-dione (1), 3-([9-methylhexadecyl]oxy)propane-1,2-diol 2, 2,3-dihydro-2,3-dioxoaaptamine (3), indol-3-aldehyde (4), methyl indole-3-carboxylate (5) 4-hydroxy-5-(indole-3-yl)−5-oxo-pentan-2-one (6), and thymidine (7) by extensive analysis of HR-ESI-MS, 1D, and 2D NMR spectral data, as well as by comparison of the spectral data with those reported in the literature. In addition, the absolute configuration of 1 was determined from the experimental ECD spectrum and comparison of this with the theoretical ECD calculations using the TDDFT method. Compounds 1 and 2 were isolated from nature for the first time. Compound 3 induced cytotoxic activity against SK-LU-1, MCF-7, HepG2, and SK-Mel-2 cell lines with IC50 values of 41.27 ± 2.63, 40.70 ± 2.65, 34.31 ± 3.43, and 36.63 ± 1.40 µM, respectively.

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