Multifocal Haemangioblastoma: Usefulness of MR Examination with a High Dose of Contrast-Medium and Late Acquisition

1997 ◽  
Vol 10 (5) ◽  
pp. 609-612
Author(s):  
I. Aprile ◽  
E. Biasizzo ◽  
M.C. De Colle ◽  
P. Dolso ◽  
G. Fabris
Keyword(s):  
Magnetic Resonance ◽  
Contrast Medium ◽  
Pulse Sequences ◽  
Magnetic Resonance Images ◽  
High Dose ◽  
Double Dose ◽  
Enhancement Pattern ◽  
Post Contrast ◽  
Contrast Medium Administration ◽  
High Doses

A rare cerebral tumour is described with a particular enhancement pattern in post-contrast medium administration magnetic resonance images. The tumour was a supratentorial, multifocal haemangioblastoma, whose solid components did not enhance in pulse sequences acquired after contrast medium administration (double dose), but only in later acquisitions (after about 1 hour). This particular behaviour suggests using contrast medium at high doses with late acquisitions when a cerebral haemangioblastoma is suspected.

scholarly journals Contrast-enhanced computed tomography of the liver, gall bladder and urogenital tract in female red-eared terrapins (Trachemys scripta elegans)

2017 ◽  
Vol 62 (No. 12) ◽  
pp. 674-680 ◽  
Author(s):  
V. Sochorcova ◽  
P. Proks ◽  
E. Cermakova ◽  
Z. Knotek
Keyword(s):  
Computed Tomography ◽  
Gall Bladder ◽  
Contrast Medium ◽  
Bladder Wall ◽  
Post Contrast ◽  
Contrast Medium Administration ◽  
Contrast Enhanced ◽  
Enhanced Computed Tomography ◽  
Contrast Enhanced Computed Tomography ◽  
Contrast Studies

The aim of the present study was to evaluate the feasibility of contrast-enhanced computed tomography for organ morphology and perfusion in five captive terrapins. Native scans were performed and afterwards an iodinated non-ionic contrast media was manually administered through the jugular vein catheter. Post-contrast CT scans were taken 20 (T<sub>20</sub>), 60 (T<sub>60</sub>) and 180 (T<sub>180</sub>) seconds after the contrast medium administration. Maximum contrast enhancement of the kidneys and the liver was detected at T<sub>20</sub> and T<sub>60</sub>, respectively. The gall bladder content, the urinary bladder content and ovarian follicles were all without contrast enhancement in all five terrapins. Gall bladder wall thickness was 0.9 mm in all terrapins. Enhancement of the gall bladder wall in post-contrast studies was considered excellent, good or poor in two terrapins, two terrapins and one terrapin, respectively, with a mean score of 1.8 ± 0.84 over all contrast studies. Enhancement of the ureters in post-contrast studies was considered excellent in all terrapins in all contrast studies. Peak aortic enhancement was reached 20 seconds after contrast medium administration with the peak enhancement of 213.5 ± 41 HU in four terrapins and 560 HU in one terrapin. Peak hepatic vein enhancement after contrast medium administration was recorded 20 and 60 seconds in two and three terrapins, respectively. In conclusion, contrast-enhanced computed tomography proved to be a valuable method for clinical examination of the liver, gall bladder, kidneys, ureters, urinary bladder and ovarian follicles in red-eared terrapins.

scholarly journals Chloroquine Is Grossly Overdosed and Overused but Well Tolerated in Guinea-Bissau

2008 ◽  
Vol 53 (1) ◽  
pp. 180-185 ◽  
Author(s):  
Johan Ursing ◽  
Poul-Erik Kofoed ◽  
Amabelia Rodrigues ◽  
Yngve Bergqvist ◽  
Lars Rombo
Keyword(s):  
Plasmodium Falciparum ◽  
Adverse Events ◽  
Standard Dose ◽  
High Dose ◽  
Routine Practice ◽  
Double Dose ◽  
Normal Dose ◽  
Guinea Bissau ◽  
High Doses ◽  
Low Prevalence

ABSTRACT High chloroquine doses are commonly prescribed in Guinea-Bissau. Double-dose chloroquine has been shown to be more efficacious (92% efficacy) than the standard dose (80% efficacy). However, chloroquine is toxic when overdosed, and it was not known if the high doses prescribed in Guinea-Bissau were taken or whether they caused adverse effects. We aimed to determine the dosage of chloroquine commonly prescribed, the doses commonly taken, and whether concentration-dependent adverse events occurred in routine practice. Chloroquine prescriptions by eight physicians and chloroquine intake by 102 children were recorded. Chloroquine intake and adverse events were assessed by questioning. Chloroquine concentrations in whole blood were measured. The median total chloroquine dose prescribed and that reportedly taken were 81 and 77 mg kg−1, respectively. The total dose was usually split into two to three daily doses of 6.6 mg kg−1 each. These were taken unsupervised for a median of 5 days. Forty percent of the study children had chloroquine concentrations in the same range as those found in a previous study in which double the normal dose (50 mg kg−1) of chloroquine was taken. Only 3/102 children had Plasmodium falciparum in the blood at the time of diagnosis and treatment. No severe adverse events were reported. No adverse events were associated with higher chloroquine concentrations. High doses of chloroquine are commonly taken and well tolerated in Guinea-Bissau. Malaria diagnostics are poor, and chloroquine is commonly prescribed to children without parasitemia. Use of high-dose chloroquine is concurrent with an exceptionally low prevalence of chloroquine-resistant P. falciparum.

scholarly journals A three-dimensional computational analysis of magnetic resonance images characterizes the biological aggressiveness in malignant brain tumours

2018 ◽  
Vol 15 (149) ◽  
pp. 20180503 ◽  
Author(s):  
J. Pérez-Beteta ◽  
A. Martínez-González ◽  
V. M. Pérez-García
Keyword(s):  
Magnetic Resonance ◽  
Prognostic Value ◽  
Three Dimensional ◽  
Magnetic Resonance Images ◽  
Post Contrast ◽  
Primary Brain Tumour ◽  
Malignant Brain Tumours ◽  
Sensitivity Studies ◽  
Pre Treatment ◽  
Shape Complexity

Glioblastoma (GBM) is the most frequent and aggressive type of primary brain tumour. The development of image-based biomarkers from magnetic resonance images (MRIs) has been a topic of recent interest. GBMs on pre-treatment post-contrast T1-weighted (w) MRIs often appear as rim-shaped regions. In this research, we wanted to define rim-shape complexity (RSC) descriptors and study their value as indicators of the tumour’s biological aggressiveness. We constructed a set of widths characterizing the rim-shaped contrast-enhancing areas in T1w MRIs, defined measures of the RSC and computed them for 311 GBM patients. Survival analysis, correlations and sensitivity studies were performed to assess the prognostic value of the measurements. All measures obtained from the histograms were found to depend on the class width to some extent. Several measures (FWHM and β R ) had high prognostic value. Some histogram-independent measures were predictors of survival: maximum rim width, mean rim width and spherically averaged rim width. The later quantity allowed patients to be classified into subgroups with different rates of survival (mean difference 6.28 months, p = 0.006). In conclusion, some of the morphological quantifiers obtained from pre-treatment T1w MRIs provided information on the biological aggressiveness of GBMs. The results can be used to define prognostic measurements of clinical applicability.

Does intravenous contrast medium administration result in altered renal biomarkers? A study in clinically stable cats with and without azotemia

2021 ◽  
pp. 1098612X2110385
Author(s):  
Maria Laura Prüllage ◽  
Ilse Schwendenwein ◽  
Eva Eberspächer-Schweda ◽  
Sibylle Kneissl
Keyword(s):  
Contrast Media ◽  
Contrast Medium ◽  
Kidney Function ◽  
Kidney Injury ◽  
Intravenous Contrast ◽  
Post Contrast ◽  
Contrast Medium Administration ◽  
Intravenous Contrast Medium ◽  
Blood And Urine Samples ◽  
Contrast Media Administration

Objectives The aim of this study was to determine the prevalence of post-contrast acute kidney injury or comparable side effects on kidney function in cats receiving the non-ionic, iodinated agent ioversol and/or paramagnetic agent gadoteric acid. Methods Fifty-two animals were divided into four groups on the basis of contrast medium administration for imaging: ioversol (n = 27), gadoteric acid (n = 12), dual contrast media (n = 4) or control, which received an infusion of isotone intravenous fluids only during anaesthesia (n = 9). Blood and urine samples were obtained three times after contrast administration and compared with values obtained prior to administration of the contrast medium. Creatinine (<1.60 mg/dl), symmetric dimethylarginine (SDMA; ⩽14 μg/dl), urine protein:creatinine ratio (UPC; <0.2) and critical differences for creatinine (<0.3 mg/dl) and SDMA (<5.98 μg/dl) were measured. Results No significant short-term effects on mean creatinine, SDMA and UPC measurements were seen. Borderline proteinuria (UPC, 0.2–0.4) was detected in 11.4% of cases after contrast media administration. A UPC of more than 0.2 in five cases indicated that contrast media may affect kidney function, leading to (transient) proteinuria. Conclusions and relevance This study found no side effect on renal function following the administration of ioversol or gadoteric acid, provided patients were adequately hydrated. However, the clinical relevance of proteinuria in some cats needs to be evaluated in future studies.

Multiparametric analysis of magnetic resonance images for glioma grading and patient survival time prediction

2011 ◽  
Vol 52 (9) ◽  
pp. 1052-1060 ◽  
Author(s):  
Benjamón Garzín ◽  
Kyrre E Emblem ◽  
Kim Mouridsen ◽  
Baard Nedregaard ◽  
Paulina Due-Tønnessen ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Survival Time ◽  
Predictive Value ◽  
Magnetic Resonance Images ◽  
Image Features ◽  
Cox Proportional Hazards ◽  
Survival Prediction ◽  
Dynamic Susceptibility ◽  
Post Contrast ◽  
Time Prediction

Background A systematic comparison of magnetic resonance imaging (MRI) options for glioma diagnosis is lacking. Purpose To investigate multiple MR-derived image features with respect to diagnostic accuracy in tumor grading and survival prediction in glioma patients. Material and Methods T1 pre- and post-contrast, T2 and dynamic susceptibility contrast scans of 74 glioma patients with histologically confirmed grade were acquired. For each patient, a set of statistical features was obtained from the parametric maps derived from the original images, in a region-of-interest encompassing the tumor volume. A forward stepwise selection procedure was used to find the best combinations of features for grade prediction with a cross-validated logistic model and survival time prediction with a cox proportional-hazards regression. Results Presence/absence of enhancement paired with kurtosis of the FM (first moment of the first-pass curve) was the feature combination that best predicted tumor grade (grade II vs. grade III-IV; median AUC = 0.96), with the main contribution being due to the first of the features. A lower predictive value (median AUC = 0.82) was obtained when grade IV tumors were excluded. Presence/absence of enhancement alone was the best predictor for survival time, and the regression was significant ( P < 0.0001). Conclusion Presence/absence of enhancement, reflecting transendothelial leakage, was the feature with highest predictive value for grade and survival time in glioma patients.

scholarly journals Quantitative evaluation of enhancement pattern of dynamic enhanced magnetic resonance images of tongue squamous cell carcinomas

2005 ◽  
Vol 51 (3) ◽  
pp. 113-119
Author(s):  
Yasunori ARIYOSHI ◽  
Masashi SHIMAHARA ◽  
Yoshihiro KIMURA ◽  
Noriko NAGISA ◽  
Hiroshi TAKEISHI ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Quantitative Evaluation ◽  
Squamous Cell ◽  
Magnetic Resonance Images ◽  
Squamous Cell Carcinomas ◽  
Enhancement Pattern
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