scholarly journals Defining chronic rejection in vascularized composite allotransplantation—The American Society of Reconstructive Transplantation and International Society of Vascularized Composite Allotransplantation chronic rejection working group: 2018 American Society of Reconstructive Transplantation meeting report and white paper Research goals in defining chronic rejection in vascularized composite allotransplantation

2020 ◽  
Vol 8 ◽  
pp. 205031212094042 ◽  
Author(s):  
Christina L Kaufman ◽  
Jean Kanitakis ◽  
Annemarie Weissenbacher ◽  
Gerald Brandacher ◽  
Mandeep R Mehra ◽  
...  
Keyword(s):  
International Society ◽  
Chronic Rejection ◽  
Working Group ◽  
Functional Decline ◽  
Meeting Report ◽  
Vascularized Composite Allotransplantation ◽  
Histologic Evidence ◽  
Reconstructive Transplantation ◽  
American Society ◽  
Definition Of

Objectives: This report summarizes a collaborative effort between the American Society of Reconstructive Transplantation and the International Society of Vascularized Composite Allotransplantation to establish what is known about chronic rejection in recipients of vascularized composite allografts, with an emphasis on upper extremity and face transplants. As a picture of chronic rejection in hand and face vascularized composite allografts emerges, the results will be applied to other types of vascularized composite allografts, such as uterine transplantation. Methods: The overall goal is to develop a definition of chronic rejection in vascularized composite allografts so that we can establish longitudinal correlates of factors such as acute rejection, immunosuppressive therapy, de novo donor-specific antibody and trauma/infection and other external factors on the development of chronic rejection. As Dr Kanitakis eloquently stated at the 2017 International Society of Vascularized Composite Allotransplantation meeting in Salzburg, “Before we can correlate causative factors of chronic rejection, we have to define what chronic rejection in VCA is.” Results: The first meeting report was presented at the sixth Biennial meeting of the American Society of Reconstructive Transplantation in November 2018. Based on collaborative efforts and descriptions of clinical cases of chronic rejection in vascularized composite allograft recipients, a working definition of chronic rejection in vascularized composite allografts with respect to overt functional decline, subclinical functional decline, histologic evidence without functional decline, and normal allograft function in the absence of histologic evidence of chronic rejection is proposed. Conclusions: It is the intent of this collaborative working group that these working definitions will help to focus ongoing research to define the incidence, risk factors and treatment regimens that will identify mechanisms of chronic rejection in vascularized composite allografts. As with all good research, our initial efforts have generated more questions than answers. We hope that this is the first of many updates.

scholarly journals Meeting Report of the 13th Congress of the International Society of Vascularized Composite Allotransplantation

2018 ◽  
Vol 102 (8) ◽  
pp. 1250-1252 ◽  
Author(s):  
Annemarie Weissenbacher ◽  
Linda Cendales ◽  
Emmanuel Morelon ◽  
Palmina Petruzzo ◽  
Gerald Brandacher ◽  
...  
Keyword(s):  
International Society ◽  
Meeting Report ◽  
Vascularized Composite Allotransplantation

2.2. Working Group 2: Conceptual Definitions of Reference Coordinate Systems for Earth Dynamics

1975 ◽  
Vol 26 ◽  
pp. 21-26
Keyword(s):  
Coordinate System ◽  
Working Group ◽  
General Character ◽  
Coordinate Systems ◽  
Reference Coordinate System ◽  
Group 2 ◽  
Definition Of ◽  
Earth Dynamics

An ideal definition of a reference coordinate system should meet the following general requirements:1. It should be as conceptually simple as possible, so its philosophy is well understood by the users.2. It should imply as few physical assumptions as possible. Wherever they are necessary, such assumptions should be of a very general character and, in particular, they should not be dependent upon astronomical and geophysical detailed theories.3. It should suggest a materialization that is dynamically stable and is accessible to observations with the required accuracy.

MDS-Patienten mit stabiler Erkrankung profitieren von kontinuierlicher Azacitidin- Therapie

2010 ◽  
Vol 01 (04) ◽  
pp. 161-162
Author(s):  
Günter Springer
Keyword(s):  
Working Group ◽  
International Working Group ◽  
American Society

Patienten mit Myelodysplastischem Syndrom (MDS) und Krankheitsstabilisierung (SD) als erstes Ansprechen haben unter kontinuierlicher Behandlung mit Azacitidin (Vida-za®) gute Aussichten, noch ein Ansprechen gemäß Kriterien der International Working Group (IWG) und dadurch einen Überlebensvorteil zu erreichen. Zu diesem Ergebnis kam eine auf dem Kongress der American Society of Oncology (ASCO) vorgestellte Analyse der Zulassungsstudie AZA-001.

Middle class ideologies: Norms and historical changes.

2017 ◽  
Author(s):  
Alex Huynh ◽  
Igor Grossmann
Keyword(s):  
Middle Class ◽  
Central Feature ◽  
Intergroup Dynamics ◽  
Social Scientists ◽  
Historical Trends ◽  
Societal Norms ◽  
Norms And Values ◽  
Behavioral Tendencies ◽  
American Society ◽  
Definition Of

Ever since social scientists became interested in understanding intergroup dynamics, the topic of the “middle class” and its distinction from other groups in society became the central feature of a theoretical and empirical research enterprise. In this overview essay we discuss the beliefs, values and behavioral tendencies attributed to American middle class beliefs, and discuss their implications for understanding class-related norms and values. We end with a reflection over the historical trends that impact societal norms and the definition of middle class in the American society.

A Hull Normal Based Approach for Cylindrical Size Assessment

2011 ◽  
Vol 133 (1) ◽  
Author(s):  
Steven Turek ◽  
Sam Anand
Keyword(s):  
New York ◽  
Least Squares ◽  
Measured Data ◽  
Size Determination ◽  
Mathematical Definition ◽  
Dimensioning And Tolerancing ◽  
Normal Method ◽  
Computational Metrology ◽  
American Society ◽  
Definition Of

Digital measurement devices, such as coordinate measuring machines, laser scanning devices, and digital imaging, can provide highly accurate and precise coordinate data representing the sampled surface. However, this discrete measurement process can only account for measured data points, not the entire continuous form, and is heavily influenced by the algorithm that interprets the measured data. The definition of cylindrical size for an external feature as specified by ASME Y14.5.1M-1994 [The American Society of Mechanical Engineers, 1995, Dimensioning and Tolerancing, ASME Standard Y14.5M-1994, ASME, New York, NY; The American Society of Mechanical Engineers, 1995, Mathematical Definition of Dimensioning and Tolerancing Principles, ASME Standard Y14.5.1M-1994, ASME, New York, NY] matches the analytical definition of a minimum circumscribing cylinder (MCC) when rule no. 1 [The American Society of Mechanical Engineers, 1995, Dimensioning and Tolerancing, ASME Standard Y14.5M-1994, ASME, New York, NY; The American Society of Mechanical Engineers, 1995, Mathematical Definition of Dimensioning and Tolerancing Principles, ASME Standard Y14.5.1M-1994, ASME, New York, NY] is applied to ensure a linear axis. Even though the MCC is a logical choice for size determination, it is highly sensitive to the sampling method and any uncertainties encountered in that process. Determining the least-sum-of-squares solution is an alternative method commonly utilized in size determination. However, the least-squares formulation seeks an optimal solution not based on the cylindrical size definition [The American Society of Mechanical Engineers, 1995, Dimensioning and Tolerancing, ASME Standard Y14.5M-1994, ASME, New York, NY; The American Society of Mechanical Engineers, 1995, Mathematical Definition of Dimensioning and Tolerancing Principles, ASME Standard Y14.5.1M-1994, ASME, New York, NY] and thus has been shown to be biased [Hopp, 1993, “Computational Metrology,” Manuf. Rev., 6(4), pp. 295–304; Nassef, and ElMaraghy, 1999, “Determination of Best Objective Function for Evaluating Geometric Deviations,” Int. J. Adv. Manuf. Technol., 15, pp. 90–95]. This work builds upon previous research in which the hull normal method was presented to determine the size of cylindrical bosses when rule no. 1 is applied [Turek, and Anand, 2007, “A Hull Normal Approach for Determining the Size of Cylindrical Features,” ASME, Atlanta, GA]. A thorough analysis of the hull normal method’s performance in various circumstances is presented here to validate it as a superior alternative to the least-squares and MCC solutions for size evaluation. The goal of the hull normal method is to recreate the sampled surface using computational geometry methods and to determine the cylinder’s axis and radius based upon it. Based on repetitive analyses of random samples of data from several measured parts and generated forms, it was concluded that the hull normal method outperformed all traditional solution methods. The hull normal method proved to be robust by having a lower bias and distributions that were skewed toward the true value of the radius, regardless of the amount of form error.

The Impact of the Privacy Rule on Cancer Research: Variations in Attitudes and Application of Regulatory Standards

2009 ◽  
Vol 27 (24) ◽  
pp. 4014-4020 ◽  
Author(s):  
Elizabeth Goss ◽  
Michael P. Link ◽  
Suanna S. Bruinooge ◽  
Theodore S. Lawrence ◽  
Joel E. Tepper ◽  
...  
Keyword(s):  
Cancer Research ◽  
Future Research ◽  
Research Committee ◽  
Data Repositories ◽  
Privacy Rule ◽  
Regulatory Standards ◽  
American Society ◽  
Definition Of ◽  
High Level ◽  
The Impact

Purpose The American Society of Clinical Oncology (ASCO) Cancer Research Committee designed a qualitative research project to assess the attitudes of cancer researchers and compliance officials regarding compliance with the US Privacy Rule and to identify potential strategies for eliminating perceived or real barriers to achieving compliance. Methods A team of three interviewers asked 27 individuals (13 investigators and 14 compliance officials) from 13 institutions to describe the anticipated approach of their institutions to Privacy Rule compliance in three hypothetical research studies. Results The interviews revealed that although researchers and compliance officials share the view that patients' cancer diagnoses should enjoy a high level of privacy protection, there are significant tensions between the two groups related to the proper standards for compliance necessary to protect patients. The disagreements are seen most clearly with regard to the appropriate definition of a “future research use” of protected health information in biospecimen and data repositories and the standards for a waiver of authorization for disclosure and use of such data. Conclusion ASCO believes that disagreements related to compliance and the resulting delays in certain projects and abandonment of others might be eased by additional institutional training programs and consultation on Privacy Rule issues during study design. ASCO also proposes the development of best practices documents to guide 1) creation of data repositories, 2) disclosure and use of data from such repositories, and 3) the design of survivorship and genetics studies.

scholarly journals Assessment of Course-Based Undergraduate Research Experiences: A Meeting Report

2014 ◽  
Vol 13 (1) ◽  
pp. 29-40 ◽  
Author(s):  
Lisa Corwin Auchincloss ◽  
Sandra L. Laursen ◽  
Janet L. Branchaw ◽  
Kevin Eagan ◽  
Mark Graham ◽  
...  
Keyword(s):  
Undergraduate Research ◽  
Biology Education ◽  
Operational Definition ◽  
Future Research ◽  
Meeting Report ◽  
Research Experience ◽  
Research Experiences ◽  
Undergraduate Research Experiences ◽  
Foundation Program ◽  
Definition Of

The Course-Based Undergraduate Research Experiences Network (CUREnet) was initiated in 2012 with funding from the National Science Foundation program for Research Coordination Networks in Undergraduate Biology Education. CUREnet aims to address topics, problems, and opportunities inherent to integrating research experiences into undergraduate courses. During CUREnet meetings and discussions, it became apparent that there is need for a clear definition of what constitutes a CURE and systematic exploration of what makes CUREs meaningful in terms of student learning. Thus, we assembled a small working group of people with expertise in CURE instruction and assessment to: 1) draft an operational definition of a CURE, with the aim of defining what makes a laboratory course or project a “research experience”; 2) summarize research on CUREs, as well as findings from studies of undergraduate research internships that would be useful for thinking about how students are influenced by participating in CUREs; and 3) identify areas of greatest need with respect to CURE assessment, and directions for future research on and evaluation of CUREs. This report summarizes the outcomes and recommendations of this meeting.

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