Resolution of giant ocular surface squamous neoplasia with topical 5-fuorouracil 1%
2019 ◽
Vol 7
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pp. 2050313X1984339
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Keyword(s):
An 82-year-old man presented with a left eye elevated single ocular surface squamous neoplasia. The tumor involved 360° of limbus, three quadrants of cornea and conjunctiva; this was compatible with the diagnosis of giant ocular surface squamous neoplasia. Topical 5-fluorouracil 1% was planned four times daily for 1 week followed by 3 weeks off-treatment. Patient inadvertently continued 5-fluorouracil, four times daily for 4 weeks, presenting with clinical resolution of the ocular surface squamous neoplasia and subtotal corneal epithelial defect associated with 5-fluorouracil toxicity. One month later, we observed a transparent cornea and no signs of toxicity. Total tumor resolution was observed for at least 6 months of follow-up.
2013 ◽
Vol 156
(6)
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pp. 1095-1101
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Keyword(s):
2011 ◽
Vol 250
(3)
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pp. 455-457
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Keyword(s):