Thromboelastometry early identifies thrombotic complications related to COVID-19: A case report

COVID-19 is a contagious infectious disease, which quickly spreads worldwide, whose clinical presentation includes from mild flu-like symptoms to pneumonia and severe acute respiratory syndrome. The severe presentation of the disease can affect different organs and systems. Coagulopathy has been associated with a worse clinical outcome, with manifestations such as pulmonary embolism and systemic arterial thrombosis. Thromboelastometry has been used to identify hypercoagulability in early stages of disease. We report the case of a 59-year-old woman with COVID-19 infection complicated by pulmonary embolism and acute arterial thrombosis associated with critical lower limb ischemia requiring amputation. This report showed a case of thrombotic complication in patient with infection caused by novel coronavirus 2019 whose thromboelastometry allowed the early identification of hypercoagulability pattern. This is a single case report and the use of thromboelastometry should be further evaluated in large prospective cohort studies.

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Concomitant Acute Limb Ischemia and Pulmonary Embolism in the Course of SARS-CoV-2 Infection: Case Report

10.21203/rs.3.rs-429395/v1 ◽

2021 ◽

Author(s):

Mahassine El harras ◽

AMAL ELOUARRADI ◽

SALMA ABDELADIM ◽

FATIMAZAHRA MERZOUK ◽

MERYEM KASSIMI ◽

...

Keyword(s):

Pulmonary Embolism ◽

Case Report ◽

Venous Thrombosis ◽

Initial Treatment ◽

Limb Ischemia ◽

Acute Limb Ischemia ◽

Significant Morbidity ◽

Mild Form ◽

Thrombotic Complications ◽

Prophylactic Anticoagulation

Abstract Background: The new 2019 coronavirus disease (COVID-19) is associated with significant morbidity and mortality. Thrombotic complications are increasingly recognized as an important part of this disease. Thromboprophylaxis with anti-platelet drugs and anticoagulants are recommended in the initial treatment of the disease.Case presentation: We report the case of a patient hospitalized for a mild form of COVID19 pneumonia, who was admitted, one month later, acute limb ischemia and pulmonary embolism despite antithrombotic prophylaxis. Conclusion: Most reported cases are either arterial or venous thrombosis. The concomitant combination of arterial and venous thrombosis is rarely reported. The prophylactic anticoagulation strategy in the SARS- Cov 2 infection is steel not well established.

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Thromboelastometry Early Identifies Thrombotic Complications Related to Covid-19: A Case Report

10.21203/rs.3.rs-68755/v1 ◽

2020 ◽

Author(s):

Raissa Lanna Araújo San Martin ◽

Tomaz Crochemore ◽

Felicio Aragão Savioli ◽

Fernanda Oliveira Coelho ◽

Rogério da Hora Passos

Keyword(s):

Infectious Disease ◽

Pulmonary Embolism ◽

Lower Limb ◽

Early Identification ◽

Arterial Thrombosis ◽

Clinical Presentation ◽

Limb Ischemia ◽

Case Presentation ◽

Lower Limb Ischemia ◽

Thrombotic Complications

Abstract Background: Covid-19 is a contagious infectious disease, which quickly spread worldwide, whose clinical presentation includes from mild symptoms such as flu to pneumonia and severe acute respiratory syndrome. The severe presentation of the disease can affect different organs and systems. Coagulopathy has been associated with a worse clinical outcome, with manifestations such as pulmonary embolism and systemic arterial thrombosis. Thromboelastometry has been used to identify hypercoagulability in early stages of disease. Case presentation: We report the case of a 59-year-old woman with Covid-19 infection complicated by pulmonary embolism and acute arterial thrombosis associated with critical lower limb ischemia requiring amputation. Conclusions: In this case, thromboelastometry allowed the early identification of hypercoagulability pattern. This reported case showed that the early thromboelastometry can be useful to identify hypercoagulable state to guide the anticoagulant therapy and to avoid thrombotic complications.

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Late Brachial Plexopathy due to Radiation-Induced Fibrosis. A single case report illustrating the importance of electrophysiology and MRI in differenzial diagnostics for delayed radiation-induced plexopathy

Klinische Neurophysiologie ◽

10.1055/s-0030-1250843 ◽

2010 ◽

Vol 41 (01) ◽

Author(s):

TN Witt ◽

UM Ganswindt ◽

A Staebler ◽

C Weiss

Keyword(s):

Case Report ◽

Single Case ◽

Brachial Plexopathy ◽

Single Case Report ◽

Radiation Induced

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A rare coexistence of acromegaly, myasthenia gravis, sicca syndrome, and elevated serum IgG4 levels: A single case report

Endocrine Abstracts ◽

10.1530/endoabs.70.aep708 ◽

2020 ◽

Author(s):

Wan-Chen Wu ◽

Huang Abel Po-Hao

Keyword(s):

Case Report ◽

Myasthenia Gravis ◽

Single Case ◽

Elevated Serum ◽

Sicca Syndrome ◽

Single Case Report ◽

Serum Igg4

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Sequential bilateral Behçet’s neuroretinitis associated with prepapillary vitreous exudate: case report

Journal of Ophthalmic Inflammation and Infection ◽

10.1186/s12348-020-00226-y ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Imen Ksiaa ◽

Safa Ben Aoun ◽

Sourour Zina ◽

Dhouha Nefzi ◽

Sana Khochtali ◽

...

Keyword(s):

Case Report ◽

Single Case ◽

Signal Loss ◽

Fiber Layer ◽

Swept Source ◽

Single Case Report ◽

Shadowing Effect ◽

Eye Involvement ◽

The Right ◽

Inflammatory Changes

Abstract Objective To describe a case of Behçet disease (BD) uveitis manifesting with sequential bilateral neuroretinitis associated with prepapillary inflammatory vitreous exudate (PIVE). Material and methods A single case report documented with multimodal imaging. Results A 37-year-old man developed neuroretinitis with associated PIVE in the left eye. He was diagnosed with ocular toxoplasmosis and treated accordingly based on positive serologic testing and negative work-up for other entities, including BD. The disease course was favorable, but 1 year later a similar neuroretinitis developed in the right eye. Extraocular features of BD became evident only at the time of the second eye involvement, and the patient received corticosteroid and immunosuppressive therapy. Swept source (SS) OCT showed at the acute phase in both eyes a typical “mushroom-shaped” prepapillary hyperreflectivity of the PIVE. SS OCT angiography (OCTA) demonstrated a corresponding prepapillary hypointense area due to shadowing effect, decreasing in size while scanning deeper layers. It also detected peripapillary retinal hypervascularity in both eyes and a sectoral area of flow signal loss in the first involved left eye. Visual acuity improved following the resolution of the PIVE and associated acute inflammatory changes in both eyes. The left eye showed residual optic disc pallor and retinal nerve fiber layer defects. Conclusion Sequential bilateral neuroretinitis associated with PIVE may occur before other clinical features of BD become evident. SS OCT and OCTA can provide useful information for the diagnosis and management of this rare, but typical, ocular manifestation of BD uveitis.

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