A review of the contemporary management of upper urinary tract urothelial carcinoma

2017 ◽  
Vol 11 (1) ◽  
pp. 51-57
Author(s):  
Abhishek Reekhaye ◽  
Seshadri Sriprasad ◽  
Sanjeev Madaan
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Upper Urinary Tract ◽  
Rare Tumour ◽  
Endoscopic Techniques ◽  
Upper Tract ◽  
Urothelial Carcinomas ◽  
Urinary Tract Urothelial Carcinoma

Upper tract urothelial carcinoma (UTUC) is relatively rare and accounts for approximately 5% of all urothelial carcinomas. The estimated annual incidence of UTUC in Western countries is about two new cases per 100,000 inhabitants. The management of patients with upper tract urothelial carcinomas has changed significantly over the last decade with improved diagnostic techniques and treatment options. The gold-standard treatment used to be open radical nephroureterectomy with removal of the ipsilateral bladder cuff. The use of minimally invasive techniques for the diagnosis and management of upper urinary tract urothelial carcinoma is however expanding and has led to a paradigm shift in treatment strategies of upper tract urothelial carcinomas. In this article, we review the current diagnostic modalities and various endoscopic techniques being currently used in the management of this relatively rare tumour.

scholarly journals Upper urinary tract urothelial carcinoma with loco-regional nodal metastases: insights from the Upper Tract Urothelial Carcinoma Collaboration

2011 ◽  
Vol 108 (8) ◽  
pp. 1286-1291 ◽  
Author(s):  
Ramy F. Youssef ◽  
Shahrokh F. Shariat ◽  
Yair Lotan ◽  
Christopher G. Wood ◽  
Arthur I. Sagalowsky ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Upper Urinary Tract ◽  
Upper Tract Urothelial Carcinoma ◽  
Nodal Metastases ◽  
Upper Tract ◽  
Urinary Tract Urothelial Carcinoma

scholarly journals Hypercalcemia an exceptional complication in upper urinary tract urothelial carcinoma

2021 ◽  
Vol 2021 (2) ◽  
Author(s):  
Issam Jandou ◽  
Elmehdi Wichou ◽  
Adnane Ettanji ◽  
Amine Moataz ◽  
Dakir Mohammed ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Poor Prognosis ◽  
Bladder Tumor ◽  
Upper Urinary Tract ◽  
Paraneoplastic Syndromes ◽  
Clinical Symptomatology ◽  
Upper Tract ◽  
Urinary Tract Urothelial Carcinoma

Abstract Tumors of the upper urinary tract are discovered, either by clinical symptomatology or as part of the evaluation of a bladder tumor. Hypercalcemia is one of the most common paraneoplastic syndromes and an exceptional complication of urothelial carcinoma of the upper tract. Several physiopathological mechanisms have been proposed to explain this rare and serious complication. Hypercalcemia is often correlated with tumors with a poor prognosis.

INVASIVE UPPER URINARY TRACT UROTHELIAL CARCINOMA WITH ATYPICAL CLINIC: CASE REPORT

2017 ◽  
Vol 22 (4) ◽  
pp. 378-381
Author(s):  
Augustinas Matulevičius ◽  
Edmundas Štarolis
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urothelial Carcinoma ◽  
Metastatic Tumor ◽  
Tumor Location ◽  
Upper Urinary Tract ◽  
Upper Tract ◽  
Urothelial Carcinomas ◽  
Chronic Urinary Tract Infection

Key words: invasive upper tract urothelial carcinoma, radical nephroureterectomy, chemotherapy treatment. Based on literature sources Urothelial carcinomas (UCs) are the fourth most common tumors. They can be located in the lower (bladder and urethra) or upper (pyelocaliceal cavities and ureter) urinary tract. Herein, we report a rare case of upper tract high malignancy urothelial carcinoma with atypical clinic which looks like an apostematous pyelonephritis. Upper tract urothelial carcinomas that invade the muscle wall usually have poor prognosis. Retrospectively assessing our patient has the most common symptoms of urinary tract infection and malignancy. It was non-visible hematuria, flank pain, chronic urinary tract infection, and also systemic symptoms (including anorexia, weight loss, malaise, fatigue, fever, and night sweats). The right diagnose we have determined by biopsy and CTU. Open RNU with bladder cuff excision is the standard for high-risk UTUC, regardless of tumor location and bladder cuff removal is imperative. AC adjuvant chemotherapy is the most widely used treatment in patients with cancer after undergoing surgery. Unfortunately the overall survival rate of urothelial metastatic tumor for this day is poor.

scholarly journals Comparison of oncologic and functional outcomes between radical nephroureterectomy and segmental ureterectomy for upper urinary tract urothelial carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tae Heon Kim ◽  
Chung Un Lee ◽  
Minyong Kang ◽  
Hwang Gyun Jeon ◽  
Byong Chang Jeong ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Functional Outcomes ◽  
Upper Urinary Tract ◽  
Rank Test ◽  
Radical Nephroureterectomy ◽  
Free Survival ◽  
Significant Difference ◽  
Segmental Ureterectomy ◽  
Urinary Tract Urothelial Carcinoma

AbstractThis study aims to compare oncologic and functional outcomes after radical nephroureterectomy (RNU) and segmental ureterectomy (SU) in patients with upper urinary tract urothelial carcinoma (UTUC). We retrospectively collected data on patients who underwent either RNU or SU of UTUC. Propensity score matching was performed among 394 cases to yield a final cohort of 40 RNU and 40 SU cases. Kaplan–Meier analysis and the log-rank test were used to compare overall survival (OS), cancer-specific survival (CSS), progression-free survival (PFS), and intravesical recurrence-free survival (IVRFS) between the groups. We also compared the change in postoperative estimated glomerular filtration rate (eGFR). There was no significant difference in terms of CSS, PFS, and IVRFS between the RNU and SU groups, but the RNU group had a better OS than the SU group (p = 0.032). Postoperative eGFR was better preserved in the SU group than in the RNU group (p < 0.001). SU provides comparable CSS, PFS, and IVRFS for patients with UTUC compared to RNU, even in patients with advanced-stage and/or high-grade cancer. Further, SU achieves better preservation of renal function.

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