scholarly journals Acute Transverse Myelitis Caused by Echovirus 11 in a Pediatric Patient

2018 ◽  
Vol 5 ◽  
pp. 2329048X1775152 ◽  
Author(s):  
Heidi L. Moline ◽  
Peter I. Karachunski ◽  
Anna Strain ◽  
Jayne Griffith ◽  
Cynthia Kenyon ◽  
...  
Keyword(s):  
Transverse Myelitis ◽  
Interdisciplinary Team ◽  
Cervical Cord ◽  
Acute Flaccid Myelitis ◽  
Department Of Health ◽  
Acute Transverse Myelitis ◽  
Pediatric Neurologist ◽  
The Right ◽  
Infectious Etiology ◽  
Pediatric Infection

A 12-year-old boy presented with acute flaccid weakness of the right upper extremity and was found to have acute flaccid myelitis with transverse myelitis involving the cervical cord (C1-T1). An interdisciplinary team-based approach was undertaken, including input from a generalist, an infectious diseases physician, and a pediatric neurologist. Consultation was sought from the Minnesota Department of Health to investigate for a potential etiology and source of the responsible infection. Evaluation for an infectious etiology demonstrated infection with human echovirus 11. The patient recovered with some disability. Echovirus 11 is among the more common etiologies of acute flaccid myelitis and should be considered in the differential diagnosis of this increasingly recognized pediatric infection.

Neurological manifestations of scrub typhus in adults

2016 ◽  
Vol 47 (1) ◽  
pp. 22-25 ◽  
Author(s):  
Abhinav Rana ◽  
Sanjay K Mahajan ◽  
Arindam Sharma ◽  
Sudhir Sharma ◽  
Balbir S Verma ◽  
...  
Keyword(s):  
Scrub Typhus ◽  
Transverse Myelitis ◽  
Neurological Dysfunction ◽  
Neurological Manifestations ◽  
Focal Neurological Deficit ◽  
Altered Sensorium ◽  
Csf Analysis ◽  
Acute Transverse Myelitis ◽  
The Right ◽  
Bilateral Papilloedema

In order to study the neurological manifestations in adult patients suffering from scrub typhus, 323 patients aged over 18 years, admitted with a positive diagnosis, were screened for neurological dysfunction; 37 patients with symptoms and/or signs suggestive of neurological dysfunction were included in the study. Of these, 31 (84%) patients had altered sensorium, four (11%) had cerebellitis, one (2%) patient had acute transverse myelitis and one (2%) had bilateral papilloedema without focal neurological deficit. Of the 31 patients with altered sensorium, 15 (40%) had meningoencephalitis, three (8%) had seizures, two (5%) had cerebral haemorrhages, one (2%) had a presentation likened to neuroleptic malignant syndrome (NMS) and one (2%) had a 6th nerve palsy with inflammation of the right cavernous sinus. Cerebrospinal fluid (CSF) analysis was abnormal in 23 patients (raised lymphocytes in 68%, raised protein in 80%). All patients improved with anti-rickettsial therapy.

scholarly journals Clinical Approach to Pediatric Transverse Myelitis, Neuromyelitis Optica Spectrum Disorder and Acute Flaccid Myelitis

Children ◽  
2019 ◽  
Vol 6 (5) ◽  
pp. 70 ◽  
Author(s):  
Cynthia Wang ◽  
Benjamin Greenberg
Keyword(s):  
Clinical Presentation ◽  
Bladder Dysfunction ◽  
Transverse Myelitis ◽  
Bowel Dysfunction ◽  
Spectrum Disorder ◽  
Clinical Approach ◽  
Acute Flaccid Myelitis ◽  
Acute Transverse Myelitis ◽  
Immune Mediated

Pediatric transverse myelitis (TM) is an acquired, immune-mediated disorder that leads to injury of the spinal cord and often manifests as weakness, numbness, bowel dysfunction, and/or bladder dysfunction. Multiple etiologies for myelitis can result in a similar clinical presentation, including idiopathic transverse myelitis (TM), multiple sclerosis (MS), neuromyeltis optica spectrum disorder (NMOSD) associated with anti-aquaporin 4 antibodies, MOG antibody-associated disease, and acute flaccid myelitis (AFM). Diagnosis relies on clinical recognition of the syndrome and confirming inflammation through imaging and/or laboratory studies. Acute treatment is targeted at decreasing immune-mediated injury, and chronic preventative therapy may be indicated if TM is determined to be a manifestation of a relapsing disorder (i.e., NMOSD). Timely recognition and treatment of acute transverse myelitis is essential, as it can be associated with significant morbidity and long-term disability.

scholarly journals Case Report: Acute Transverse Myelitis

2021 ◽  
Vol 9 (T3) ◽  
pp. 182-185
Author(s):  
Petrus Nilwan Ginting ◽  
Kiking Ritarwan
Keyword(s):  
Spinal Cord ◽  
Motor Neuron ◽  
Transverse Myelitis ◽  
Magnetic Resonance Imaging Examination ◽  
Inflammatory Disorder ◽  
Case Presentation ◽  
Acute Transverse Myelitis ◽  
Sensory Disturbances ◽  
The Right ◽  
Whole Spine

BACKGROUND: Acute transverse myelitis (ATM) could be a pathogenetically heterogeneous inflammatory disorder affecting the spinal cord at one or more segments [1]. CASE PRESENTATION: We report a 69-year-old man presented with complaints of weakness of the arms and legs since 3 weeks before hospital admission. On physical and neurological examination was found Tetraparese, lower motor neuron in the superior limb and upper motor neuron in the inferior limb, sensory disturbances at C6-C7 levels, and autonomic impairment retention of urine and bladder dysfunction. On magnetic resonance imaging examination of the whole spine vertebra, a diffuse process was found in the spinal cord along with the cervical 7 to Th12-L1. Differential diagnosis is with transverse myelitis, multiple sclerosis, and no picture of syringomyelia. The patient was treated with steroids. Acute transverse myelitis is an inflammatory disorder of the spinal cord with various causes. CONCLUSION: Clinical examination and investigations are very important to establish the diagnosis and determine the right management so that the expected outcome is obtained.

scholarly journals Meningitis as a recurrent manifestation of anti-AQP4/anti-MOG negative neuromyelitis optica spectrum disorder: a case report

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chenyang Zhang ◽  
Kang Zhang ◽  
Bing Chen ◽  
Jiao Yin ◽  
Miaomiao Dong ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Area Postrema ◽  
Neurological Diseases ◽  
Brain Magnetic Resonance Imaging ◽  
Transverse Myelitis ◽  
Corticosteroid Treatment ◽  
Neck Stiffness ◽  
Mixed Cell ◽  
Glucose Levels ◽  
The Right

Abstract Background Neuromyelitis optica spectrum disorders (NMOSD), a group of autoimmune neurological diseases, involve the optic nerve, spinal cord, and brain. Meningitis is rarely reported as the primary clinical manifestation of both anti-aquaporin-4 (AQP4)/ anti-myelin oligodendrocyte glycoprotein (MOG) antibody-negative NMOSD (NMOSDneg). Case presentation A 30-year-old man initially presented with fever, headache, and neck stiffness. Lumbar puncture revealed mixed cell reaction and decreased glucose levels. As a result, tuberculous meningitis was suspected. After 1 month, the patient developed longitudinally extensive transverse myelitis and area postrema syndrome. This was followed by the presentation of meningitis-like symptoms once again in the third attack, but his condition eventually improved after corticosteroid treatment without relapse for 2 years. However, he was readmitted to our hospital owing to symptoms of diplopia, hiccup, and numbness in the right hand. Brain magnetic resonance imaging (MRI) revealed that the area postrema still contained lesions. Spinal MRI revealed several segmental enhancements at the C4–C5, T1, and T5 levels. Anti-AQP4 and anti-MOG antibodies were persistently absent in the serum and cerebrospinal fluid (CSF). The patient was finally diagnosed with NMOSDneg. Conclusions Meningitis could be a recurrent manifestation of NMOSDneg and requires more careful evaluation.

scholarly journals Acute transverse myelitis after SARS-CoV-2 infection: a rare complicated case of rapid onset paraplegia

2021 ◽  
Author(s):  
Hamze Shahali ◽  
Ali Ghasemi ◽  
Ramin Hamidi Farahani ◽  
Amir Nezami Asl ◽  
Ebrahim Hazrati
Keyword(s):  
Transverse Myelitis ◽  
Rapid Onset ◽  
Complicated Case ◽  
Acute Transverse Myelitis

scholarly journals Prognostic factors for relapse and outcome in pediatric acute transverse myelitis

2021 ◽  
Author(s):  
Jelte Helfferich ◽  
Arlette L. Bruijstens ◽  
Yu Yi M. Wong ◽  
E. Danielle van Pelt ◽  
Maartje Boon ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Transverse Myelitis ◽  
Acute Transverse Myelitis

scholarly journals Access to treatment for phenylketonuria by judicial means in Rio Grande do Sul, Brazil

2015 ◽  
Vol 20 (5) ◽  
pp. 1607-1616 ◽  
Author(s):  
Luciano Mangueira Trevisan ◽  
Tatiele Nalin ◽  
Tassia Tonon ◽  
Lauren Monteiro Veiga ◽  
Paula Vargas ◽  
...  
Keyword(s):  
Genetic Diseases ◽  
Rio Grande ◽  
Right To Health ◽  
The State ◽  
Rio Grande Do Sul ◽  
Access To Treatment ◽  
Unified Health System ◽  
Department Of Health ◽  
Legal Remedy ◽  
The Right

Treatment of phenylketonuria (PKU) includes the use of a metabolic formula which should be provided free of charge by the Unified Health System (SUS). This retrospective, observational study sought to characterize judicial channels to obtain PKU treatment in Rio Grande do Sul (RS), Brazil. Lawsuits filed between 2001- 2010 and having as beneficiaries PKU patients requesting treatment for the disease were included. Of 20 lawsuits filed, corresponding to 16.8% of RS patients with PKU, 19 were retrieved for analysis. Of these, only two sought to obtain therapies other than metabolic formula. In all the other 17 cases, prior treatment requests had been granted by the State Department of Health. Defendants included the State (n = 19), the Union (n = 1), and municipalities (n = 4). In 18/19 cases, the courts ruled in favor of the plaintiffs. Violation of the right to health and discontinuation of State-provided treatment were the main reasons for judicial recourse. Unlike other genetic diseases, patients with PKU seek legal remedy to obtain a product already covered by the national pharmaceutical assistance policy, suggesting that management failures are a driving factor for judicialization in Brazil.

Childhood Acute Transverse Myelitis: Clinical Profile, Outcome, and Association With Antiganglioside Antibodies

2009 ◽  
Vol 24 (4) ◽  
pp. 466-471 ◽  
Author(s):  
Veena Kalra ◽  
Suvasini Sharma ◽  
Jitendra Sahu ◽  
Naveen Sankhyan ◽  
Rama Chaudhry ◽  
...  
Keyword(s):  
Transverse Myelitis ◽  
Clinical Profile ◽  
Acute Transverse Myelitis
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