Central retinal vein occlusion associated with platelet activation

Purpose:The aim of this article is to determine and compare the platelet activation by three main platelet activation parameters: mean platelet volume, platelet distribution width, and plateletcrit in patients with central retinal vein occlusion and control subjects.Methods:This study included 30 patients with nonischemic central retinal vein occlusion and 30 control subjects. The levels of mean platelet volume, platelet distribution width, and plateletcrit were measured in all groups.Results:The mean serum level of mean platelet volume was 10.01 ± 0.89 fl in central retinal vein occlusion group and 8.74 ± 1.45 fl in control group. The mean serum level of platelet distribution width was 14.31 ± 1.49% and 11.65 ± 1.81% in central retinal vein occlusion group and control group, respectively. Mean serum plateletcrit value was 0.27 ± 0.07% in central retinal vein occlusion group and 0.23 ± 0.07% in control group. Mean platelet volume, platelet distribution width, and plateletcrit levels were significantly higher in central retinal vein occlusion patients than controls ( p < 0.05).Conclusion:Subclinical platelet activation reflected by mean platelet volume, platelet distribution width, and plateletcrit may have an impact on the genesis of vessel occlusion in central retinal vein occlusion. The results may be important for the clinical management of patients with central retinal vein occlusion.

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Branch retinal vein occlusion associated with platelet activation

TURKISH JOURNAL OF MEDICAL SCIENCES ◽

10.3906/sag-1807-223 ◽

2019 ◽

Author(s):

EMRULLAH BEYAZYILDIZ ◽

MEHMET ÇITIRIK ◽

MERT ŞİMŞEK ◽

ÖZLEM BEYAZYILDIZ ◽

İBRAHİM CELALETTİN HAZNEDAROĞLU

Keyword(s):

Serum Level ◽

Retinal Vein Occlusion ◽

Platelet Activation ◽

Branch Retinal Vein Occlusion ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Vein Occlusion ◽

Group 2 ◽

Group 1

Background/Aim: The aim of this study is to search subclinical platelet activation via detecting three important platelet activation parameters; Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), and Plateletcrit (PCT) in patients with branch retinal vein occlusion (BRVO) in comparison to those in the healthy control subjects. Material and Methods: This prospective study had included 43 patients with BRVO (Group 1) and 40 control subjects (Group 2). The levels of MPV, PDW, and PCT were measured in the all of the studied groups. Results: The mean serum level of MPV value 7.64 ± 0.64 in group 1 and 7.39 ± 0.42 in group 2. Mean serum level of PDW was 15.01 ± 1.56 in group 1 and 14.43 ± 1.03 in group 2. Mean serum PCT value was 0.19 ± 0.05 in group 1 and 0.16 ± 0.04 in group 2. MPV, PDW, and PCT levels were significantly increased in BRVO patients (P < 0.05). Conclusions: Subclinical platelet activation reflected by MPV, PDW, and PCT may have an impact on the genesis of vessel occlusion in BRVO. The results may be important for the clinical management of patients with BRVO. Key Words: Branch retinal vein occlusion, mean platelet volume, plateletcrit, platelet distribution width, platelet parameters, retina.

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Mean platelet volume and central retinal vein occlusion in hypertensive patients

Canadian Journal of Ophthalmology ◽

10.1016/j.jcjo.2018.04.014 ◽

2019 ◽

Vol 54 (2) ◽

pp. 275-279 ◽

Cited By ~ 2

Author(s):

Pritam Bawankar ◽

Preetam Samant ◽

Tatyarao Lahane ◽

Ragini Parekh ◽

Sayalee Lahane

Keyword(s):

Retinal Vein Occlusion ◽

Central Retinal Vein Occlusion ◽

Mean Platelet Volume ◽

Platelet Volume ◽

Hypertensive Patients ◽

Vein Occlusion ◽

Central Retinal Vein

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Mean Platelet Volume and Platelet Distribution Width as Markers in the Diagnosis of Acute Gangrenous Appendicitis

Disease Markers ◽

10.1155/2015/542013 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4 ◽

Cited By ~ 9

Author(s):

Zhe Fan ◽

Jiyong Pan ◽

Yingyi Zhang ◽

Ziyi Wang ◽

Ming Zhu ◽

...

Keyword(s):

Mean Platelet Volume ◽

Medical Condition ◽

Roc Curves ◽

Disease Diagnosis ◽

Control Group ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Gangrenous Appendicitis ◽

Wbc Count

Introduction.Acute gangrenous appendicitis (AGA) is a common medical condition; however, the grade of appendicitis usually cannot be established preoperatively. We have attempted to identify some indicators, such as the mean platelet volume (MPV) and the platelet distribution width (PDW), to diagnose AGA.Aims.To evaluate whether or not the MPV and PDW are suitable markers to diagnose AGA.Methods.A retrospective study of 160 patients with AGA and 160 healthy patients was undertaken. Disease diagnosis was confirmed based on the pathologic examination of surgical specimens. Patient white blood cell (WBC) count, neutrophil ratio (NR), platelet (PLT) count, MPV, PDW, and hematocrit (HCT) were analyzed. Receiver operating characteristic (ROC) curves were used to evaluate the sensitivity and specificity of these indices in AGA.Results.There were no significant differences between the AGA and control groups in age and gender. Compared to the control group, the WBC count, NR, and PDW were significantly higher (P<0.001, resp.) and the MPV and HCT were significantly lower (P<0.001, resp.) in the AGA group. The diagnostic specificities of the WBC count, NR, PLT count, MPV, PDW, and HCT were 86.3%, 92.5%, 58.1%, 81.7%, 83.9%, and 66.3%, respectively. Therefore, the NR had the highest diagnostic specificity for the diagnosis of AGA.Conclusions.This is the first study to assess the MPV and PDW in patients with AGA. Our present study showed that the MPV is reduced and the PDW is increased in patients with AGA; the sensitivity of PDW was superior to the MPV. A decreased MPV value and an increased PDW could serve as two markers to diagnose AGA. The NR had the highest specificity for the diagnosis of AGA.

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Significant elevation of aqueous endothelin-1 in central retinal vein occlusion

PLoS ONE ◽

10.1371/journal.pone.0252530 ◽

2021 ◽

Vol 16 (6) ◽

pp. e0252530

Author(s):

Hae Min Kang ◽

Md. Hasanuzzaman ◽

So Won Kim ◽

Hyoung Jun Koh ◽

Sung Chul Lee

Keyword(s):

Retinal Vein Occlusion ◽

Aqueous Humor ◽

Central Retinal Vein Occlusion ◽

Intravitreal Bevacizumab ◽

Control Group ◽

Endothelin 1 ◽

Intravitreal Bevacizumab Injection ◽

Vein Occlusion ◽

The Mean ◽

Central Retinal Vein

Purpose To investigate aqueous humor concentrations of endothelin-1 (ET-1) in patients with central retinal vein occlusion (CRVO) compared with patients with branch retinal vein occlusion (BRVO) and a normal control group. Methods A total 80 subjects were included in this prospective study, including 15 patients with CRVO, 20 patients with BRVO, and 45 patients who underwent cataract surgery and had no concomitant ocular disease. Aqueous humor levels of ET-1 were obtained before intravitreal bevacizumab injection (IVB) and after 1 month. Results At baseline, the mean aqueous ET-1 level was 12.7±3.6 pg/mL in the CRVO group, 8.0±2.3 pg/mL in the BRVO group, and 2.0±0.9 pg/mL in the control group (P<0.001). After IVB, the mean aqueous level of ET-1 was 3.4±1.9 pg/mL (0.5–6.9 pg/mL) in the CRVO group and 1.8±1.0 pg/mL (0.3–3.2 pg/mL) in the BRVO group (P = 0.008). The mean aqueous ET-1 level was significantly reduced in both the patients with CRVO and those with BRVO (P<0.001). Conclusion The mean aqueous humor ET-1 level was significant higher in the patients with CRVO than those with BRVO and in the control group. After IVB, the mean level was significantly reduced in both the patients with CRVO and those with BRVO.

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SAT0241 PLATELET INDICES COULD BE SIMPLE RELIABLE PREDICTORS OF THROMBOTIC EVENTS IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.1935 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1063.1-1063

Author(s):

J. Zhao ◽

M. LI ◽

Q. Wang ◽

X. Tian ◽

X. Zeng

Keyword(s):

Platelet Activation ◽

Antiphospholipid Syndrome ◽

Mean Platelet Volume ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Platelet Indices ◽

Logistic Analysis ◽

Large Platelet ◽

Pathogenic Process

Background:Platelet activation is considered as a pivot pathogenic process to be responsible for thromboembolism in antiphospholipid syndrome (APS). severalstudies shown that platelet indices including platelet distribution width (PDW), mean platelet volume (MPV), large platelet rate (P-LCR) are associated with platelet activation.Objectives:This study aims to determine the correlation between platelet indices and thrombotic events in patients with APS.Methods:Platelet activation is considered as a pivot pathogenic process to be responsible for thromboembolism in antiphospholipid syndrome (APS). severalstudies shown that platelet indices including platelet distribution width (PDW), mean platelet volume (MPV), large platelet rate (P-LCR) are associated with platelet activation.Results:A total of 207 patients [135(65.2%) female, 72(34.8%) male], medianage 35(IQR 10)] was classified into thrombotic group (n=150,72.5%) and non-thrombotic group(n=57,27.5%). PDW, MPV, P-LCR were significantly higher in thrombotic group than non-thrombotic group (13.0±3.4 vs. 11.2±7.3)p<0.001, 10.7±1.4vs.10.0±3.0,p<0.001, 30.25±11.6vs. 25.1±10.4 p<0.001, respectively]. No differences in age, WBC count, hsCRP and C3 were observed between groups. Also, HGB was found to be notably higher in thrombotic group than non-thrombotic group (143±29 vs. 132±15, p=0.001).Upon univariate logistic analysis, PDW (OR 1.554, 95%CI 1.289-1.873, p<0.001), MPV (OR 1.772, 95%CI 1.268-2.476, p=0.001), P-LCR (OR 1.089, 95%CI 1.040-1.140, p<0.001) were all significantly associated with the occurrenceof thrombosis. In multivariate logistic analysis, only PDW and positive LAwere identified to be risk factors of thrombotic events (Table 1). The ROC curve showed that PDW combinedwith positive LAwas a reliable indicator of thrombotic events with an AUC of 0.796 (95%CI 0.728-0.864). The optimal cut-off value for PDW was 12.4fl with a sensitivity of 72.0% and specificity of 77.2%.Conclusion:This study confirmed that PDW, P-LCR and MPV (especially PDW) were significantly associated with thrombotic events in APS patients, which could support the theory of platelet activation being a crucial factor of thrombosis inAPS. Caution should be raised when patients with positive LA has relatively high PDW level.Disclosure of Interests:None declared

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Is there a diagnostic value for the platelet indices patients in pulmonary embolism?

Hong Kong Journal of Emergency Medicine ◽

10.1177/1024907917743489 ◽

2017 ◽

Vol 25 (2) ◽

pp. 91-94

Author(s):

İbrahim Çevik ◽

Hüseyin Narcı ◽

Güllü Akbaydoğan Dündar ◽

Cüneyt Ayrık ◽

Seyran B Babuş

Keyword(s):

Pulmonary Embolism ◽

Mean Platelet Volume ◽

Area Under The Curve ◽

Control Group ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Platelet Indices ◽

Platelet Number ◽

D Dimer

Background: Pulmonary embolism is a common disease with a high mortality risk. It has recently been reported that platelet indices may be diagnostic in pulmonary embolism. Objective: In this study, we aimed to determine the diagnostic value of platelet indices in acute pulmonary embolism. Methods: The study group was composed of 61 patients diagnosed with pulmonary embolism and a control group of 67 subjects without pulmonary embolism. Patient age, sex, leukocyte and platelet number, hemoglobin concentration (Hb), mean platelet volume, platelet distribution width, red blood cell distribution width, C-reactive protein, D-Dimer, and troponin I levels were retrospectively analyzed and compared between the two groups. Results: There was no significant difference between age and platelet number of pulmonary embolism and control group. In pulmonary embolism group, platelet distribution width level was significantly high (p = 0.002), whereas mean platelet volume level was significantly lower (p = 0.038). Receiver operating characteristic curve analysis revealed that a mean platelet volume cut-off of 9 fL had a sensitivity of 35%, a specificity of 89.55%, and area under the curve of 0.589 for pulmonary embolism, while a platelet distribution width cut-off of 12.8 fL had a sensitivity of 61%, a specificity of 71.64%, and area under the curve of 0.661. Platelet distribution width and D-dimer levels had a significant positive correlation with each other, whereas there was no significant correlation between mean platelet volume and D-dimer. Conclusion: Platelet distribution width values of the pulmonary embolism group were higher than those of control group. Although the area under the curve of platelet distribution width is slightly better than for platelet number or mean platelet volume, it does not seem that this parameter has better diagnostic accuracy than the other two.

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Association of platelet count and platelet indices with cranial meningioma

Romanian Neurosurgery ◽

10.33962/roneuro-2020-017 ◽

2020 ◽

pp. 123-126

Author(s):

Yasar Karatas ◽

Fatih Keskin ◽

Mehmet Fatih Erdi ◽

Bulent Kaya ◽

Densel Arac ◽

...

Keyword(s):

Platelet Count ◽

Mean Platelet Volume ◽

Small Sample ◽

Control Group ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Healthy Group ◽

Platelet Indices ◽

Significant Difference

Introduction and Objectives: In this study, we aimed to investigate whether platelet count (PLT) and platelet indices included mean platelet volume (MPV), platecrit (PCT), platelet distribution width (PDW) values can be used as diagnostic markers in cranial meningiomas. Materials and Methods: The study included results of 29 patient and 47 healthy contributors. Based on pathologies, the patients were divided into two groups. The first group included meningioma patients and the second one included healthy individuals. Healthy contributors named control group. Platelet count and platelet indices were determined using Sysmex XN 550 haematology analyzer. The preoperative platelet count (PLT) and platelet indices included mean platelet volume (MPV), platecrit (PCT), platelet distribution width (PDW) values were recorded from the routine laboratory tests. Results: There was no statistically significant difference in PLT between the meningioma and healthy groups (p = 0.217). There was a statistically significant difference in PCT between the meningioma group and the healthy group (p = 0.002). There was a statistically significant difference in PDW between meningioma group and healthy group (p = 0.001). In terms of MPV, there was a statistically significant difference between meningioma group and the healthy group (p = 0.001) Conclusion: Platelet count and indices are easily available in the routine blood tests. Despite the retrospective design and small sample size, our findings suggest that altered MPV, PDW and PCT levels might serve as potential biomarkers for the diagnosis of meningiomas.

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Fibrinolytic Therapy in Central Retinal Vein Occlusion

10.1055/s-0039-1689365 ◽

1975 ◽

Author(s):

J. E. Pettit ◽

E. M. Kohner ◽

G. J. Bulpit ◽

A. M. Hamilton

Keyword(s):

Retinal Vein Occlusion ◽

Central Retinal Vein Occlusion ◽

Warfarin Therapy ◽

Fibrinolytic Therapy ◽

Control Group ◽

Controlled Clinical Trial ◽

Initial Symptom ◽

Vein Occlusion ◽

One Year ◽

Central Retinal Vein

A controlled clinical trial was conducted on patients with central retinal vein occlusion who presented within seven days of their initial symptom and in whom there was no contraindication to fibrinolytic therapy. There were 20 treated and 20 control patients between 1970 and 1974.Treatment comprised 72 hours full-dose streptokinase (SK) therapy followed by 48 hours heparin and six months warfarin therapy. Progress was monitored for one year by periodic ophthalmological examinations, including colour and fluorescent photography.The final visual acuity was similar in both groups of patients. Vitreal haemorrhage occurred in three patients receiving SK and these patients remained blind. Two control group patients had vitreal haemorrhage from new blood vessels six months after presenting. Four control patients developed thrombotic glaucoma; this painful end result was not observed in SK treated patients.

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Functional benefits of a chorioretinal anastomosis at 2 years in eyes with a central retinal vein occlusion treated with ranibizumab compared with ranibizumab monotherapy

BMJ Open Ophthalmology ◽

10.1136/bmjophth-2021-000728 ◽

2021 ◽

Vol 6 (1) ◽

pp. e000728

Author(s):

Ian L McAllister ◽

Lynne A Smithies ◽

Fred K Chen ◽

David A Mackey ◽

Paul G Sanfilippo

Keyword(s):

Retinal Vein Occlusion ◽

Central Retinal Vein Occlusion ◽

Diastolic Pressure ◽

Venous Pressure ◽

Control Group ◽

Vein Occlusion ◽

Registration Number ◽

Chorioretinal Anastomosis ◽

The Mean ◽

Central Retinal Vein

ObjectiveTo evaluate the functional benefits (best corrected visual acuity (BCVA), central subfield thickness, injection loads, central venous pressure (CVP)) of a laser-induced chorioretinal anastomosis (L-CRA) in patients with central retinal vein occlusion (CRVO) treated with ranibizumab compared with ranibizumab monotherapy.Methods and AnalysisThis is a post-hoc analysis of the 2-year randomised ranibizumab plus L-CRA for CRVO trial. Twenty-four patients (82.5%) developed a functioning or successful L-CRA; outcome effects were monitored in the monthly as-needed ranibizumab phase from months 7 to 24 and compared with the ranibizumab monotherapy group (n=29).ResultsFrom months 7 to 24, the mean (95% CI) injection load for the functioning L-CRA group was 2.18 (1.57 to 2.78) compared with 7.07 (6.08 to 8.06) for the control group (p<0.0001). The mean BCVA was averaged across all timepoints between the control and functioning L-CRA groups (average difference=11.46 (3.16 to 19.75) letters, p=0.01). At 2 years, there was an 82.5% reduction in the odds of high CVP (greater or equal to central retinal artery diastolic pressure) for those with a successful L-CRA compared with controls (p<0.0001).ConclusionFor patients with CRVO, adding L-CRA as a causal-based treatment to conventional therapy reduced CVP and injection loads and offered improved BCVA.Trial registration number ACTRN12612000004864.

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Investigation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with tinnitus

The Journal of Laryngology & Otology ◽

10.1017/s0022215117002481 ◽

2018 ◽

Vol 132 (2) ◽

pp. 129-132 ◽

Cited By ~ 4

Author(s):

B Ulusoy ◽

K Bozdemir ◽

M Akyol ◽

H İ Mişe ◽

A Kutluhan ◽

...

Keyword(s):

Mean Platelet Volume ◽

Statistical Significance ◽

Neutrophil To Lymphocyte Ratio ◽

Control Group ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Platelet To Lymphocyte Ratio ◽

Distribution Width ◽

Significance Level ◽

Lymphocyte Ratio

AbstractObjective:This study aimed to evaluate patients with tinnitus in terms of mean platelet volume and platelet distribution width, and to explore neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio, recently reported in the literature as being possible inflammation markers.Methods:This study comprised 64 tinnitus patients and 64 age-matched healthy controls. Statistical significance level was accepted as p < 0.05.Results:Mean platelet volume (t = 3.245, p = 0.002) and platelet distribution width (Z = 3.945, p < 0.001) were significantly higher in the patient group than the control group.Conclusion:The results suggest that a prothrombotic condition might play a role in the pathophysiology of tinnitus.

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