scholarly journals Beyond Seattle: WATS and Advanced Imaging in Barrett’s Esophagus

2021 ◽  
Vol 1 (1) ◽  
pp. 32-38
Author(s):  
Sharmila Anandasabapathy ◽  
Nabil M. Mansour
Keyword(s):  
Artificial Intelligence ◽  
Barrett’S Esophagus ◽  
Esophageal Adenocarcinoma ◽  
Barrett's Esophagus ◽  
Standard Of Care ◽  
Endoscopic Surveillance ◽  
Computer Assisted ◽  
3D Analysis ◽  
Advanced Imaging ◽  
Current Standard

Barrett’s esophagus is the sole known precursor for esophageal adenocarcinoma. Endoscopic surveillance for Barrett’s esophagus is recommended to help identify and manage dysplasia, with the ultimate goal being prevention or early detection of esophageal adenocarcinoma. The current standard of care for endoscopic surveillance for Barrett’s esophagus, the Seattle protocol, has many drawbacks. Methods to overcome these disadvantages have been an active area of research. This review will focus on some of the technologies to help improve dysplasia surveillance in Barrett’s esophagus, including advanced endoscopic imaging, artificial intelligence, and wide-area transepithelial sampling with computer-assisted 3D analysis (WATS-3D).

scholarly journals Optical Detection and Eradication of Dysplastic Barrett's Esophagus

2003 ◽  
Vol 2 (4) ◽  
pp. 289-302 ◽  
Author(s):  
Louis-Michel Wong Kee Song ◽  
Kenneth K. Wang
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Sampling Error ◽  
Imaging Techniques ◽  
Standard Of Care ◽  
Diagnostic Techniques ◽  
Endoscopic Surveillance ◽  
Current Status ◽  
Delay In Diagnosis ◽  
Multiple Biopsies

Dysplastic Barrett's esophagus is a condition that offers multiple diagnostic and therapeutic challenges. The diagnosis of dysplasia within Barrett's esophagus currently relies on periodic endoscopic surveillance with multiple biopsies, a methodology limited by random sampling error, inconsistent histopathologic interpretation and delay in diagnosis. Optical spectroscopic and imaging techniques have the potential to identify dysplastic or early neoplastic lesions in real-time. These diagnostic modalities are needed to enhance the endoscopic surveillance of Barrett's esophagus in the future as well as help to define lesions for endoscopic therapy. Esophagectomy has been the standard of care for Barrett's esophagus with high-grade dysplasia although it is a procedure associated with significant morbidity and mortality. Minimally invasive endoscopic ablative therapies are attractive and less morbid alternatives to esophagectomy, with promising results obtained from the use of light-activated drugs (i.e., photodynamic therapy). The combination of novel optical diagnostic techniques and therapies will provide the endoscopist with much needed tools that can considerably enhance the management of patients with Barrett's esophagus. This article reviews the current status and future prospects of optical-based modalities for diagnosis and therapy of dysplastic Barrett's esophagus.

scholarly journals Endoscopic Surveillance of Barrett’s Esophagus Using Volumetric Laser Endomicroscopy With Artificial Intelligence Image Enhancement

2019 ◽  
Vol 157 (2) ◽  
pp. 303-305 ◽  
Author(s):  
Arvind J. Trindade ◽  
Matthew J. McKinley ◽  
Cathy Fan ◽  
Cadman L. Leggett ◽  
Allon Kahn ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Image Enhancement ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Endoscopic Surveillance

Sa1897 Predictors of Progression to High Grade Dysplasia and Esophageal Adenocarcinoma During Barrett's Esophagus Endoscopic Surveillance

2015 ◽  
Vol 148 (4) ◽  
pp. S-349-S-350
Author(s):  
Mariana Omodeo ◽  
Lisandro Pereyra ◽  
Daniela La Salvia ◽  
Claudia M. Godoy ◽  
Pablo Luna ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Esophageal Adenocarcinoma ◽  
Barrett's Esophagus ◽  
High Grade Dysplasia ◽  
Endoscopic Surveillance ◽  
High Grade

scholarly journals Barrett’s esophagus: novel strategies for screening and surveillance

2019 ◽  
Vol 10 ◽  
pp. 204062231983785 ◽  
Author(s):  
Vedha Sanghi ◽  
Prashanthi N. Thota
Keyword(s):  
Barrett’S Esophagus ◽  
Esophageal Adenocarcinoma ◽  
Barrett's Esophagus ◽  
Eradication Therapy ◽  
Oral Microbiome ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Computer Assisted ◽  
Screening And Surveillance ◽  
Esophageal Capsule

Barrett’s esophagus is the precursor lesion for esophageal adenocarcinoma. Screening and surveillance of Barrett’s esophagus are undertaken with the goal of earlier detection and lowering the mortality from esophageal adenocarcinoma. The widely used technique is standard esophagogastroduodenoscopy with biopsies per the Seattle protocol for screening and surveillance of Barrett’s esophagus. Surveillance intervals vary depending on the degree of dysplasia with endoscopic eradication therapy confined to patients with Barrett’s esophagus and confirmed dysplasia. In this review, we present various novel techniques for screening of Barrett’s esophagus such as unsedated transnasal endoscopy, cytosponge with trefoil factor-3, balloon cytology, esophageal capsule endoscopy, liquid biopsy, electronic nose, and oral microbiome. In addition, advanced imaging techniques such as narrow band imaging, dye-based chromoendoscopy, confocal laser endomicroscopy, volumetric laser endomicroscopy, and wide-area transepithelial sampling with computer-assisted three-dimensional analysis developed for better detection of dysplasia are also reviewed.

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