Effect of Multiple Doses of Clarithromycin and Amoxicillin on IL-6, IFNγ and IL-10 Plasma Levels in Patients with Community Acquired Pneumonia

Three patients received single doses of Sr85 and one Ca45 as well, the plasma levels, and urinary and fecal excretions being followed for 3–4 weeks. Calculations were then made to predict plasma levels and excretions following the administration of 12 small doses to each patient, and values predicted were compared with those found. Changes in calcium metabolism limited the predictive value of single-dose data, but when variations in urinary calcium could be allowed for, predicted and found values agreed well. The factors involved in extrapolation from single to multiple doses are discussed. Within certain limitations, the extrapolation appears valid and may be applicable to the problems involved in the investigation of Sr90 as well, although the fact that the latter is ingested over long periods of time makes comparison with single-dose data more hazardous. Submitted on December 21, 1962

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Antiarrhythmic efficacy of propafenone: Evaluation of effective plasma levels following single and multiple doses

European Journal of Clinical Pharmacology ◽

10.1007/bf00608213 ◽

1986 ◽

Vol 30 (6) ◽

pp. 665-671 ◽

Cited By ~ 11

Author(s):

L. Frabetti ◽

B. Marchesini ◽

A. Capucci ◽

C. Cavallini ◽

S. Gubelli ◽

...

Keyword(s):

Plasma Levels ◽

Single And Multiple Doses ◽

Multiple Doses ◽

Antiarrhythmic Efficacy

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Plasma levels of soluble intercellular adhesion molecule-1 as a biomarker for disease severity of patients with community-acquired pneumonia

Clinica Chimica Acta ◽

10.1016/j.cca.2016.10.030 ◽

2016 ◽

Vol 463 ◽

pp. 174-180 ◽

Cited By ~ 4

Author(s):

Pin-Yu Chang ◽

Shih-Ming Tsao ◽

Jer-Hwa Chang ◽

Ming-Hsien Chien ◽

Wen-Yueh Hung ◽

...

Keyword(s):

Disease Severity ◽

Adhesion Molecule ◽

Plasma Levels ◽

Community Acquired Pneumonia ◽

Intercellular Adhesion ◽

Intercellular Adhesion Molecule ◽

Intercellular Adhesion Molecule 1 ◽

Soluble Intercellular Adhesion Molecule

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Selected Biomarkers Correlate with the Origin and Severity of Sepsis

Mediators of Inflammation ◽

10.1155/2018/7028267 ◽

2018 ◽

Vol 2018 ◽

pp. 1-11 ◽

Cited By ~ 10

Author(s):

Michal Holub ◽

Olga Džupová ◽

Michaela Růžková ◽

Alžběta Stráníková ◽

Eva Bartáková ◽

...

Keyword(s):

Intensive Care Unit ◽

Plasma Levels ◽

Plasma Concentrations ◽

Community Acquired Pneumonia ◽

Heparin Binding ◽

Soluble Cd14 ◽

Gram Negative ◽

Heparin Binding Protein ◽

Microbial Etiology ◽

Time Point

The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP;n=10) and infective endocarditis (IE;n=11) compared to those with bacterial meningitis (BM;n=18). Next, cortisol levels were higher in IE patients than in those with BM and CAP, and at one time point, cortisol was also higher in patients with gram-negative sepsis when compared to those with gram-positive infections. Furthermore, cortisol and MCP-1 levels correlated positively with the daily measured SOFA score. In addition, HBP levels were significantly higher in patients with IE than in those with BM. Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortisol plasma levels are associated with sepsis-induced organ dysfunction.

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P191: Combined use of multidimensional prognostic index (MPI) and procalcitonin plasma levels in predicting one-month mortality in older patients hospitalized with community-acquired pneumonia: a prospective study

European Geriatric Medicine ◽

10.1016/s1878-7649(14)70366-3 ◽

2014 ◽

Vol 5 ◽

pp. S144

Author(s):

A. Pilotto ◽

F. Addante ◽

S. Bazzano ◽

M. Miolo ◽

M.M. Mion ◽

...

Keyword(s):

Prospective Study ◽

Plasma Levels ◽

Older Patients ◽

Prognostic Index ◽

Community Acquired Pneumonia ◽

Combined Use ◽

A Prospective Study

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Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community acquired pneumonia

AJP Lung Cellular and Molecular Physiology ◽

10.1152/ajplung.00162.2021 ◽

2021 ◽

Author(s):

Kristin Ehrlich ◽

Jochen Wilhelm ◽

Philipp Markart ◽

Heike Weisser ◽

Jens-Christian Wolff ◽

...

Keyword(s):

Plasma Levels ◽

Specific Effect ◽

Community Acquired Pneumonia ◽

Elderly Subjects ◽

Factor Xii ◽

Contact Phase ◽

Strong Negative Correlation ◽

Albumin Ratio ◽

C1 Esterase Inhibitor ◽

Esterase Inhibitor

Sex-dependent differences in immunity and coagulation play an active role in the outcome of community-acquired pneumonia (CAP). Contact phase proteins act at the crossroads between inflammation and coagulation thus representing a point of convergence in host defense against infection. Here, we measured the levels of factor XII (FXII), FXIIa-C1 esterase inhibitor (C1INH) complexes, and high molecular weight kininogen (HK) in plasma of CAP patients and correlated them to clinical disease severity. Levels of FXIIa-C1INH/albumin ratio were elevated, irrespective of sex, in plasma of CAP patients (n=139) as compared to age-matched donors (n=58). No simultaneous decrease in FXII levels, indicating its consumption, was observed. Stratification by sex revealed augmented FXII levels in plasma of CAP women as compared to sex-matched donors yet no apparent differences in men. This sex-specific effect was, however, attributable to lower FXII levels in female donors relative to men donors. Plasma estradiol levels mirrored those for FXII. Levels of HK/albumin ratio were decreased in CAP plasma as compared to donors, however, after stratification by sex, this difference was only observed in women and was related to higher HK/albumin values in female donors as opposed to male donors. Finally, strong negative correlation between plasma levels of HK/albumin ratio and CAP severity, as assessed by CRB65 score, in males and females was observed. Our study identifies sex-dependent differences in plasma levels of the contact phase proteins in elderly subjects that may contribute to specific clinical outcomes in CAP between men and women.

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