scholarly journals Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model

Blood ◽  
2013 ◽  
Vol 122 (24) ◽  
pp. 3960-3963 ◽  
Author(s):  
Valeria Lascano ◽  
Marco Guadagnoli ◽  
Jan G. Schot ◽  
Dieuwertje M. Luijks ◽  
Jeroen E. J. Guikema ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Mouse Model ◽  
Disease Progression ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Lymphocytic Leukemia ◽  
Leukemic Cells ◽  
Key Points

Key Points APRIL significantly accelerates CLL onset in TCL1-Tg mice. APRIL-mediated prosurvival effects in leukemic cells depend on TACI and not BCMA ligation.

scholarly journals Meta-Analysis Reveals Significant Sex Differences in Chronic Lymphocytic Leukemia Progression in the Eµ-TCL1 Transgenic Mouse Model

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1980 ◽  
Author(s):  
Maximilian Koch ◽  
Sebastian Reinartz ◽  
Julia Saggau ◽  
Gero Knittel ◽  
Natascha Rosen ◽  
...  
Keyword(s):  
Animal Model ◽  
Chronic Lymphocytic Leukemia ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Meta Analysis ◽  
Transgenic Mouse Model ◽  
Careful Consideration ◽  
Lymphocytic Leukemia ◽  
Murine Models ◽  
Future Studies

The Eµ-TCL1 transgenic mouse model represents the most widely and extensively used animal model for chronic lymphocytic leukemia (CLL). In this report, we performed a meta-analysis of leukemia progression in over 300 individual Eµ-TCL1 transgenic mice and discovered a significantly accelerated disease progression in females compared to males. This difference is also reflected in an aggressive CLL mouse model with additional deletion of Tp53 besides the TCL1 transgene. Moreover, after serial adoptive transplantation of murine CLL cells, female recipients also succumbed to CLL earlier than male recipients. This sex-related disparity in the murine models is markedly contradictory to the human CLL condition. Thus, due to our observation we urge both careful consideration in the experimental design and accurate description of the Eµ-TCL1 transgenic cohorts in future studies.

PKCβ is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCβ as a therapeutic target in chronic lymphocytic leukemia

Blood ◽  
2009 ◽  
Vol 113 (12) ◽  
pp. 2791-2794 ◽  
Author(s):  
Claudia Holler ◽  
Josefina D. Piñón ◽  
Ursula Denk ◽  
Christoph Heyder ◽  
Sebastian Hofbauer ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Mouse Model ◽  
B Cell ◽  
Transgenic Mouse ◽  
Specific Inhibitor ◽  
Cell Receptor ◽  
Transgenic Mouse Model ◽  
Lymphocytic Leukemia

Abstract The development and the propagation of chronic lymphocytic leukemia (CLL) has been linked to signaling via the B-cell receptor (BCR). Protein kinase C β (PKCβ) is an essential signaling element of the BCR and was recently shown to be overexpressed in human CLL. We used the TCL1 transgenic mouse model to directly target PKCβ in the development of murine CLL. TCL1 overexpression did restore the CD5+ B-cell population that is absent in PKCβ-deficient mice. However, PKCβ-deleted TCL1 transgenic mice did not develop a CLL disease, suggesting a role of PKCβ in the establishment of the malignant clone. Moreover, targeting of PKCβ with the specific inhibitor enzastaurin led to killing of human CLL samples in vitro. We thus propose that PKCβ may be a relevant target for the treatment of CLL.

scholarly journals Triterpenoids Display Single Agent Anti-tumor Activity in a Transgenic Mouse Model of Chronic Lymphocytic Leukemia and Small B Cell Lymphoma

PLoS ONE ◽  
2007 ◽  
Vol 2 (6) ◽  
pp. e559 ◽  
Author(s):  
Christina L. Kress ◽  
Marina Konopleva ◽  
Vanesa Martínez-García ◽  
Maryla Krajewska ◽  
Sophie Lefebvre ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Mouse Model ◽  
B Cell ◽  
Transgenic Mouse ◽  
Cell Lymphoma ◽  
Single Agent ◽  
B Cell Lymphoma ◽  
Transgenic Mouse Model ◽  
Lymphocytic Leukemia ◽  
Anti Tumor Activity

scholarly journals Asynchronous expression of myeloid antigens in leukemic cells in a PML/RARalpha transgenic mouse model

2006 ◽  
Vol 39 (5) ◽  
pp. 615-620 ◽  
Author(s):  
B.A.A. Santana ◽  
M.C. Pintão ◽  
R.S. Abreu e Lima ◽  
P.S. Scheucher ◽  
G.A.S. Santos ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Leukemic Cells ◽  
Myeloid Antigens

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

Blood ◽  
2014 ◽  
Vol 123 (25) ◽  
pp. 3914-3924 ◽  
Author(s):  
Tobias Berg ◽  
Silvia Thoene ◽  
Damian Yap ◽  
Tracee Wee ◽  
Nathalie Schoeler ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Polycomb Group ◽  
Key Points ◽  
Polycomb Group Gene

Key Points A functional demonstration of the oncogenic role of mutated EZH2 in a mouse model is presented. The global effects of mutated EZH2 on expression and epigenome have been characterized.

Pyruvate slows disease progression in a G93A SOD1 mutant transgenic mouse model

2007 ◽  
Vol 413 (3) ◽  
pp. 265-269 ◽  
Author(s):  
Jong-Ha Park ◽  
Yoon-Ho Hong ◽  
Hyun-Jung Kim ◽  
Sung-Min Kim ◽  
Min-Jeong Kim ◽  
...  
Keyword(s):  
Mouse Model ◽  
Disease Progression ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Sod1 Mutant ◽  
G93a Sod1

scholarly journals Bruton’s tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)

Blood ◽  
2014 ◽  
Vol 123 (8) ◽  
pp. 1207-1213 ◽  
Author(s):  
Jennifer A. Woyach ◽  
Engin Bojnik ◽  
Amy S. Ruppert ◽  
Matthew R. Stefanovski ◽  
Virginia M. Goettl ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Mouse Model ◽  
Tyrosine Kinase ◽  
Lymphocytic Leukemia ◽  
Bruton’S Tyrosine Kinase ◽  
Bruton's Tyrosine Kinase ◽  
Genetic Inactivation ◽  
Key Points

Key Points Kinase-functional BTK is important in the development and expansion of CLL. Both targeted genetic inactivation of BTK and inhibition of BTK by ibrutinib inhibit the development of CLL in the TCL1 mouse model.

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