scholarly journals TFPI cofactor function of protein S: essential role of the protein S SHBG-like domain

Blood ◽  
2014 ◽  
Vol 123 (25) ◽  
pp. 3979-3987 ◽  
Author(s):  
Natalia Reglińska-Matveyev ◽  
Helena M. Andersson ◽  
Suely M. Rezende ◽  
Björn Dahlbäck ◽  
James T. B. Crawley ◽  
...  
Keyword(s):  
Active Site ◽  
Essential Role ◽  
Protein S ◽  
Key Points ◽  
Kunitz Domain

Key Points The protein S SHBG-like domain and, more specifically, its LG1 subunit are important for binding and enhancement of TFPI. TFPI binding to the protein S SHBG-like domain likely positions TFPI Kunitz domain 2 for optimal interaction with the active site of FXa.

scholarly journals Bioinorganic Chemistry of Nickel

Inorganics ◽  
2019 ◽  
Vol 7 (11) ◽  
pp. 131
Author(s):  
Michael J. Maroney ◽  
Stefano Ciurli
Keyword(s):  
Active Site ◽  
Essential Role ◽  
Bioinorganic Chemistry

Following the discovery of the first specific and essential role of nickel in biology in 1975 (the dinuclear active site of the enzyme urease) [...]

scholarly journals COX-1–derived thromboxane A2 plays an essential role in early B-cell development via regulation of JAK/STAT5 signaling in mouse

Blood ◽  
2014 ◽  
Vol 124 (10) ◽  
pp. 1610-1621 ◽  
Author(s):  
Qiong Yang ◽  
Maohua Shi ◽  
Yujun Shen ◽  
Yingjiao Cao ◽  
Shengkai Zuo ◽  
...  
Keyword(s):  
B Cell ◽  
Essential Role ◽  
Suppressive Effect ◽  
Cell Development ◽  
B Cell Development ◽  
Dose Aspirin ◽  
Key Points ◽  
Low Dose Aspirin ◽  
Cox 1

Key Points This study demonstrated an essential role of COX-1 in early B-cell development. Low-dose aspirin may have a potential suppressive effect on B-cell development in humans.

scholarly journals Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia

Blood ◽  
2013 ◽  
Vol 122 (16) ◽  
pp. 2888-2892 ◽  
Author(s):  
Yi Zhang ◽  
Kristina Owens ◽  
Layla Hatem ◽  
Carolyn H. Glass ◽  
Kannan Karuppaiah ◽  
...  
Keyword(s):  
Myeloid Leukemia ◽  
Essential Role ◽  
Key Points ◽  
Domain Protein ◽  
Pr Domain

Key Points The MDS1-EVI1 isoform of the MECOM locus is required for MLL-AF9–induced myeloid leukemia. Within MDS1-EVI1, it is the PR domain that is essential.

Essential Role of an Active-Site Guanine inglmSRibozyme Catalysis

2007 ◽  
Vol 129 (48) ◽  
pp. 14858-14859 ◽  
Author(s):  
Daniel J. Klein ◽  
Michael D. Been ◽  
Adrian R. Ferré-D'Amaré
Keyword(s):  
Active Site ◽  
Essential Role

scholarly journals Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation

Blood ◽  
2013 ◽  
Vol 121 (10) ◽  
pp. 1839-1849 ◽  
Author(s):  
Daisuke Kurotaki ◽  
Naoki Osato ◽  
Akira Nishiyama ◽  
Michio Yamamoto ◽  
Tatsuma Ban ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Essential Role ◽  
Chromatin Signature ◽  
Monocyte Differentiation ◽  
Key Points ◽  
Myeloid Progenitors

Key Points IRF8 induces the Klf4 gene in myeloid progenitors; this transcription factor cascade is essential for Ly6C+ monocyte development. IRF8 binding to genomic targets promotes H3K4me1, a chromatin signature for promoter-distal enhancers, thereby inducing gene expression.

scholarly journals Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma

Blood ◽  
2015 ◽  
Vol 125 (1) ◽  
pp. 124-132 ◽  
Author(s):  
Andre Weilemann ◽  
Michael Grau ◽  
Tabea Erdmann ◽  
Olaf Merkel ◽  
Ulduz Sobhiafshar ◽  
...  
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Essential Role ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Key Points ◽  
Large Cell Lymphoma

Key Points IRF4 regulates MYC expression in ALCL. ALCL survival depends on IRF4/MYC signaling.

scholarly journals Essential role of class II PI3K-C2α in platelet membrane morphology

Blood ◽  
2015 ◽  
Vol 126 (9) ◽  
pp. 1128-1137 ◽  
Author(s):  
Colin Valet ◽  
Gaëtan Chicanne ◽  
Childerick Severac ◽  
Claire Chaussade ◽  
Maria A. Whitehead ◽  
...  
Keyword(s):  
Membrane Structure ◽  
Essential Role ◽  
Class Ii ◽  
Platelet Membrane ◽  
Membrane Morphology ◽  
Key Points

Key Points PI3K-C2α controls platelet membrane structure and remodeling. PI3K-C2α is a key regulator of a basal housekeeping PI3P pool in platelets.

scholarly journals Essential Role of the C-Terminal Helical Domain in Active Site Formation of Selenoprotein MsrA from Clostridium oremlandii

PLoS ONE ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. e0117836 ◽  
Author(s):  
Eun Hye Lee ◽  
Kitaik Lee ◽  
Kwang Yeon Hwang ◽  
Hwa-Young Kim
Keyword(s):  
Active Site ◽  
Essential Role ◽  
Site Formation ◽  
Helical Domain
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