scholarly journals Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells

Blood ◽  
2016 ◽  
Vol 128 (8) ◽  
pp. 1063-1075 ◽  
Author(s):  
Douaa Dhahri ◽  
Kaori Sato-Kusubata ◽  
Makiko Ohki-Koizumi ◽  
Chiemi Nishida ◽  
Yoshihiko Tashiro ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Endothelial Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Key Points ◽  
Pharmacologic Inhibition

Key Points tPA expands mesenchymal stromal cells (MSCs) in the bone marrow by a cytokine (KitL and PDGF-BB) crosstalk with endothelial cells. Pharmacologic inhibition of receptor tyrosine kinases (c-Kit and PDGFRα) impairs tPA-mediated MSC proliferation.

scholarly journals Immune dysfunctionality of replicative senescent mesenchymal stromal cells is corrected by IFNγ priming

2017 ◽  
Vol 1 (11) ◽  
pp. 628-643 ◽  
Author(s):  
Raghavan Chinnadurai ◽  
Devi Rajan ◽  
Spencer Ng ◽  
Kenneth McCullough ◽  
Dalia Arafat ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Replicative Senescence ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Human Mscs ◽  
Key Points ◽  
Immune Defects

Key Points Replication exhausted human MSCs display attenuated immunosuppressive properties partly because of defective kynurenine production. IFNγ prelicensing can rescue replicative senescence-associated immune defects of human bone marrow–derived MSCs.

Mechanisms of action and osteogenic activity of bone marrow mesenchymal stromal cells are donor dependent

2014 ◽  
Author(s):  
Julie Leotot ◽  
Angelique Lebouvier ◽  
Philippe Hernigou ◽  
Helene Rouard ◽  
Nathalie Chevallier
Keyword(s):  
Bone Marrow ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Mechanisms Of Action ◽  
Osteogenic Activity
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