scholarly journals Initiation of acute graft-versus-host disease by angiogenesis

Blood ◽  
2017 ◽  
Vol 129 (14) ◽  
pp. 2021-2032 ◽  
Author(s):  
Katarina Riesner ◽  
Yu Shi ◽  
Angela Jacobi ◽  
Martin Kräter ◽  
Martina Kalupa ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Experimental Colitis ◽  
Endothelial Activation ◽  
Host Disease ◽  
Metabolic Alterations ◽  
Graft Versus Host ◽  
Key Points ◽  
Acute Graft ◽  
Inflammatory Leukocytes

Key Points Angiogenesis preceded infiltration of inflammatory leukocytes during GVHD as well as during experimental colitis. Metabolic alterations and cytoskeleton changes occurred during early angiogenesis, but classical endothelial activation signs were absent.

scholarly journals Phase 1 multicenter trial of brentuximab vedotin for steroid-refractory acute graft-versus-host disease

Blood ◽  
2017 ◽  
Vol 129 (24) ◽  
pp. 3256-3261 ◽  
Author(s):  
Yi-Bin Chen ◽  
Miguel-Angel Perales ◽  
Shuli Li ◽  
Maria Kempner ◽  
Carol Reynolds ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Phase 1 ◽  
Multicenter Trial ◽  
Brentuximab Vedotin ◽  
Host Disease ◽  
Graft Versus Host ◽  
Key Points ◽  
Steroid Refractory ◽  
Acute Graft

Key Points BV has activity for SR-aGVHD. The MTD of BV was 0.8 mg/kg every 2 weeks for 4 doses.

scholarly journals The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease

2019 ◽  
Vol 3 (23) ◽  
pp. 4034-4042 ◽  
Author(s):  
Hrishikesh K. Srinagesh ◽  
Umut Özbek ◽  
Urvi Kapoor ◽  
Francis Ayuk ◽  
Mina Aziz ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Risk Groups ◽  
Serum Biomarkers ◽  
Dynamic Changes ◽  
Host Disease ◽  
Graft Versus Host ◽  
Key Points ◽  
Response Biomarker ◽  
Acute Graft

Key Points The MAGIC algorithm probability, computed from 2 serum biomarkers, predicts mortality in all GVHD grades after 4 weeks of treatment. Dynamic changes in the MAGIC algorithm probability occur within all biomarker risk groups and can guide therapy.

scholarly journals Pretransplant comorbidities predict severity of acute graft-versus-host disease and subsequent mortality

Blood ◽  
2014 ◽  
Vol 124 (2) ◽  
pp. 287-295 ◽  
Author(s):  
Mohamed L. Sorror ◽  
Paul J. Martin ◽  
Rainer F. Storb ◽  
Smita Bhatia ◽  
Richard T. Maziarz ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Acute Gvhd ◽  
Mortality Rates ◽  
Cumulative Effects ◽  
Host Disease ◽  
Graft Versus Host ◽  
Key Points ◽  
Comorbidity Burden ◽  
Conditioning Intensity ◽  
Acute Graft

Key Points The HCT-CI stratifies patients into 3 groups for risks of grades 3 to 4 GVHD regardless of conditioning intensity, donor, or graft types. Comorbidity burden and development of grades 2 to 4 acute GVHD have cumulative effects on mortality rates.

scholarly journals α1-Antitrypsin infusion for treatment of steroid-resistant acute graft-versus-host disease

Blood ◽  
2018 ◽  
Vol 131 (12) ◽  
pp. 1372-1379 ◽  
Author(s):  
John M. Magenau ◽  
Steven C. Goldstein ◽  
Dan Peltier ◽  
Robert J. Soiffer ◽  
Thomas Braun ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Significant Risk ◽  
Steroid Resistant ◽  
Host Disease ◽  
Graft Versus Host ◽  
Minimal Toxicity ◽  
Key Points ◽  
Clinical Responses ◽  
Acute Graft

Key PointsAAT infusion produced a high proportion of durable clinical responses in SR-aGVHD. AAT is associated with minimal toxicity and low rates of infection in patients with SR-aGVHD at significant risk for mortality.

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

Blood ◽  
2013 ◽  
Vol 122 (10) ◽  
pp. 1802-1812 ◽  
Author(s):  
Shen Dong ◽  
Sylvie Maiella ◽  
Aliénor Xhaard ◽  
Yuanyu Pang ◽  
Lynn Wenandy ◽  
...  
Keyword(s):  
Single Cell ◽  
Graft Versus Host Disease ◽  
Cell Populations ◽  
Cell Heterogeneity ◽  
Host Disease ◽  
Graft Versus Host ◽  
Key Points ◽  
Lineage Reprogramming ◽  
Single Cell Profiling ◽  
Acute Graft

Key Points Single-cell heterogeneity, rather than lineage reprogramming, explains the remarkable complexity and functional diversity of human Tregs. Altered homeostasis of Treg subpopulations in patients developing acute graft-versus-host disease.

scholarly journals Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease

Blood ◽  
2013 ◽  
Vol 122 (19) ◽  
pp. 3365-3375 ◽  
Author(s):  
Bin Xiao ◽  
Yu Wang ◽  
Wei Li ◽  
Megan Baker ◽  
Jian Guo ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Key Points ◽  
Noninvasive Biomarker ◽  
Prognosis And Prediction ◽  
Plasma Microrna ◽  
Acute Graft

Key Points Identification of a miRNA panel as a biomarker for the diagnosis, prognosis, and prediction of acute graft-versus-host disease.

scholarly journals Amphiregulin modifies the Minnesota Acute Graft-versus-Host Disease Risk Score: results from BMT CTN 0302/0802

2018 ◽  
Vol 2 (15) ◽  
pp. 1882-1888 ◽  
Author(s):  
Shernan G. Holtan ◽  
Todd E. DeFor ◽  
Angela Panoskaltsis-Mortari ◽  
Nandita Khera ◽  
John E. Levine ◽  
...  
Keyword(s):  
Risk Score ◽  
Graft Versus Host Disease ◽  
Disease Risk ◽  
Host Disease ◽  
Graft Versus Host ◽  
Steroid Response ◽  
Disease Risk Score ◽  
Key Points ◽  
Acute Graft

Key Points High-circulating AREG (≥33 pg/mL) reclassifies additional patients into HR categories and further refines the Minnesota aGVHD risk score. Patients with aGVHD and AREG ≥33 pg/mL have lower rates of steroid response, higher NRM, and poorer OS.

scholarly journals Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome

Blood ◽  
2017 ◽  
Vol 129 (15) ◽  
pp. 2172-2185 ◽  
Author(s):  
Antiopi Varelias ◽  
Kate L. Ormerod ◽  
Mark D. Bunting ◽  
Motoko Koyama ◽  
Kate H. Gartlan ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Acute Gvhd ◽  
Host Disease ◽  
Graft Versus Host ◽  
Key Points ◽  
Deficient Mice ◽  
Acute Graft ◽  
Increased Susceptibility

Key PointsRecipient-derived IL-17A is critical for the prevention of intestinal acute GVHD. Increased susceptibility to acute GVHD can be transferred to WT mice via cohousing with IL-17RA or IL-17RC–deficient mice.

scholarly journals High day 28 ST2 levels predict for acute graft-versus-host disease and transplant-related mortality after cord blood transplantation

Blood ◽  
2015 ◽  
Vol 125 (1) ◽  
pp. 199-205 ◽  
Author(s):  
Doris M. Ponce ◽  
Patrick Hilden ◽  
Christen Mumaw ◽  
Sean M. Devlin ◽  
Marissa Lubin ◽  
...  
Keyword(s):  
Cord Blood ◽  
Graft Versus Host Disease ◽  
Cord Blood Transplantation ◽  
Host Disease ◽  
Graft Versus Host ◽  
Blood Transplantation ◽  
Key Points ◽  
Related Mortality ◽  
Acute Graft

Key Points ST2 is independently associated with aGVHD after day 28 in cord blood transplantation recipients. High ST2 levels predict for increased TRM in cord blood transplantation recipients.

Sign in / Sign up

Export Citation Format

Share Document