Bone marrow microenvironment–derived signals induce Mcl-1 dependence in multiple myeloma
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Key Points Bone marrow stromal cell–derived IL-6 induces Mcl-1 dependence through transcriptional and posttranslational changes in the Bcl-2 family. Blocking IL-6 signaling pathways sensitizes myeloma to inhibitors of Bcl-2 and Bcl-2/Bcl-xL.
2019 ◽
Vol 3
(21)
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pp. 3228-3240
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2012 ◽
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2001 ◽
Vol 93
(5)
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pp. 674-680
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2003 ◽
Vol 88
(6)
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pp. 855-862
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2007 ◽
Vol 39
(3)
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pp. 366-368
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2013 ◽
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