Interleukin-5 is at 5q31 and is deleted in the 5q- syndrome
Keyword(s):
Human interleukin-5 (IL-5) is a selective eosinophilopoietic and eosinophil-activating growth hormone. By in situ hybridization this gene is mapped to chromosome 5q23.3 to 5q32. It is shown to be deleted in two patients with the 5q-syndrome and in one patient previously diagnosed with myelodysplasia whose condition had progressed to acute myeloblastic leukemia. The clustering of other genes involved in hematopoiesis (IL-3, granulocyte-macrophage colony-stimulating factor, feline sarcoma viral oncogene homolog, colony-stimulating factor 1) to the same region as IL-5 suggests a nonrandom localization and raises interesting questions concerning the evolution and regulation of these genes.
1991 ◽
Vol 88
(3)
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pp. 1048-1053
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1988 ◽
Vol 263
(27)
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pp. 13901-13908
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1991 ◽
Vol 266
(36)
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pp. 24741-24747
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2003 ◽
Vol 278
(12)
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pp. 10572-10577
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