scholarly journals Plasma zinc level and thymic hormone activity in young cancer patients

Blood ◽  
1994 ◽  
Vol 83 (3) ◽  
pp. 749-757 ◽  
Author(s):  
E Mocchegiani ◽  
P Paolucci ◽  
D Granchi ◽  
L Cavallazzi ◽  
L Santarelli ◽  
...  
Keyword(s):  
Lymphoblastic Leukemia ◽  
Young Patients ◽  
Zinc Level ◽  
Plasma Zinc ◽  
Hormone Activity ◽  
Immunological Parameters ◽  
Thymic Hormone ◽  
Zinc Levels ◽  
Plasma Zinc Level

Abstract It has been reported that in many neoplastic diseases, including leukemia, alterations in plasma zinc levels may frequently occur, although the causes for such alterations have yet to be clearly defined. Since zinc is required to induce biological activity to thymulin (Zn-FTS), a biochemical defined thymic hormone, and marginal zinc deficiencies may prevent its peripheral biological activation, we investigated the plasma level of zinc and of both active thymulin (Zn- FTS) and total zinc saturable thymulin (Zn-FTS + FTS) in 91 young patients affected by acute lymphoblastic leukemia (ALL) at various stages of the disease. It was discovered that the plasma zinc level was reduced at the onset and relapse, whereas in complete remission and in off-therapy it was in the normal range. Total zinc-saturable thymulin concentration did not change during the disease, whereas the active fraction was reduced at the onset and in relapse when compared with values observed in the other stages of the disease or in healthy controls. These data suggest that zinc plasma deficiency is present in ALL patients at the onset and during relapse, and that such a deficiency causes a decrease in the activity of thymulin despite a nearly normal production by the thymus. An impairment of peripheral immune efficiency in ALL patients is commonly found. The existence of positive correlations between zinc or active thymulin and peripheral immunological parameters (phytohemagglutinin [PHA] and concanavalin A [ConA]) at various stages of the disease suggests a link between derangement of peripheral immune function, thymic hormone activity, and zinc failure. These findings, considered together, suggest the possibility of a carefully controlled clinic trial with zinc in ALL patients at the onset and in relapse even in the light of in vitro ineffectiveness of physiological zinc or thymulin concentrations on the duplicative index of human lymphoblastoid cells.

scholarly journals Plasma zinc level and thymic hormone activity in young cancer patients

Blood ◽  
1994 ◽  
Vol 83 (3) ◽  
pp. 749-757
Author(s):  
E Mocchegiani ◽  
P Paolucci ◽  
D Granchi ◽  
L Cavallazzi ◽  
L Santarelli ◽  
...  
Keyword(s):  
Lymphoblastic Leukemia ◽  
Young Patients ◽  
Zinc Level ◽  
Plasma Zinc ◽  
Hormone Activity ◽  
Immunological Parameters ◽  
Thymic Hormone ◽  
Zinc Levels ◽  
Plasma Zinc Level

It has been reported that in many neoplastic diseases, including leukemia, alterations in plasma zinc levels may frequently occur, although the causes for such alterations have yet to be clearly defined. Since zinc is required to induce biological activity to thymulin (Zn-FTS), a biochemical defined thymic hormone, and marginal zinc deficiencies may prevent its peripheral biological activation, we investigated the plasma level of zinc and of both active thymulin (Zn- FTS) and total zinc saturable thymulin (Zn-FTS + FTS) in 91 young patients affected by acute lymphoblastic leukemia (ALL) at various stages of the disease. It was discovered that the plasma zinc level was reduced at the onset and relapse, whereas in complete remission and in off-therapy it was in the normal range. Total zinc-saturable thymulin concentration did not change during the disease, whereas the active fraction was reduced at the onset and in relapse when compared with values observed in the other stages of the disease or in healthy controls. These data suggest that zinc plasma deficiency is present in ALL patients at the onset and during relapse, and that such a deficiency causes a decrease in the activity of thymulin despite a nearly normal production by the thymus. An impairment of peripheral immune efficiency in ALL patients is commonly found. The existence of positive correlations between zinc or active thymulin and peripheral immunological parameters (phytohemagglutinin [PHA] and concanavalin A [ConA]) at various stages of the disease suggests a link between derangement of peripheral immune function, thymic hormone activity, and zinc failure. These findings, considered together, suggest the possibility of a carefully controlled clinic trial with zinc in ALL patients at the onset and in relapse even in the light of in vitro ineffectiveness of physiological zinc or thymulin concentrations on the duplicative index of human lymphoblastoid cells.

Maternal zinc supplementation improves hepatitis B antibody responses in infants but decreases plasma zinc level

2015 ◽  
Vol 55 (5) ◽  
pp. 1823-1829 ◽  
Author(s):  
Shaikh Meshbahuddin Ahmad ◽  
Mohammad Bakhtiar Hossain ◽  
Md. Monirujjaman ◽  
Sharmin Islam ◽  
Md. Nazmul Huda ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Zinc Supplementation ◽  
Zinc Level ◽  
Antibody Responses ◽  
Plasma Zinc ◽  
Plasma Zinc Level

scholarly journals Plasma zinc levels in normal and malnourished children with lower respiratory tract infection from 2 months to 5 years of age

2019 ◽  
Vol 6 (3) ◽  
pp. 1285
Author(s):  
Dinesk Kumar E. ◽  
Thumjaa Annamalai ◽  
Shafath Ahmed M. ◽  
Sundari S.
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract Infection ◽  
Lower Respiratory Tract ◽  
Zinc Level ◽  
Plasma Zinc ◽  
Malnourished Children ◽  
Zinc Levels ◽  
Age And Sex

Background: Acute Lower Respiratory Tract Infection (ALRI) is an important cause of morbidity and mortality in the developing world. Pneumonia is a severe form of ALRI that cause over 2 million deaths annually among children younger than 5 years of age. About 19% of all deaths, pneumonia is the leading cause of child mortality. Malnutrition is known to be associated with greater intensity of lower respiratory tract infections, higher the frequency of complications, longer episodes of infections. This study is to assess the plasma zinc levels in normal and malnourished children with LRI aged 2 months to 5 years.Methods: This is a case control study, which was carried out in the Department of Paediatrics, Sree Balaji Medical College and Hospital, the study period is one year from July 2016 to July 2017. 100 children between 2 months to 5 years of age with LRI was included in the study and children less than 2 months and more than 5 years. 50 Children with normal nutrition were taken as controls and 50 children with moderate and severe malnutrition were taken as cases. Age and sex were matched among cases and controls. Blood samples were collected for zinc estimation in both the cases and controls. All children were investigated and treated as per the department protocol for the particular condition. All statistical procedures were performed using SPSS v 21.0.Results: In present study, 66% of children had normal zinc levels, 34% of children had low zinc levels. The mean zinc level in our cases was 54.84±18.31 and in controls was 76.84±15.2, which was statistically significant (p = 0.000). Mean plasma zinc levels with respect to age and sex were not significant.Conclusions: Total 34% of children with LRI had low plasma zinc levels. Plasma zinc level were significantly low in malnourished children than normally nourished children with LRI, which is one of the most important cause of high childhood mortality in developing countries.

An inhibitor of thymic hormone activity in serum from patients with lymphoblastic leukemia

1980 ◽  
Vol 68 (3) ◽  
pp. 377-380 ◽  
Author(s):  
J.J. Twomey ◽  
V.M. Lewis ◽  
R. Ford ◽  
G. Goldstein
Keyword(s):  
Lymphoblastic Leukemia ◽  
Hormone Activity ◽  
Thymic Hormone

scholarly journals Relationship between Zink and Anaemica in Chronic Haemodialysis Patients

1970 ◽  
Vol 16 (1) ◽  
pp. 12-14 ◽  
Author(s):  
Nasima Akhtar ◽  
Raghib Ahsan ◽  
Md Abdul Wakil ◽  
CGM Mostafa ◽  
Sakhi Chowdhury ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Zinc Level ◽  
Chronic Haemodialysis ◽  
Plasma Zinc ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients ◽  
Haemoglobin Synthesis ◽  
Plasma Zinc Level

End stage renal disease (ESRD) patients receiving haemodialysis (HD) are frequently associatedwith anaemia. Zinc, being an important nutrient for haemoglobin synthesis, was studied for it'seffect, if any, on renal disease associated anaemia among patients in the HD unit of BSMMU(formerly IPGMR), Dhaka. Surprisingly, a tow plasma zinc level and a high corpuscular (RBC)zinc level was observed. All of our subjects were found anaemic. A significant correlation wasobserved between plasma zinc level on one hand and haemoglobin level as well as RBC countson the other hand. There are several suggestions for this low plasma and high corpuscular zinclevel. However, this altered zinc level in plasma and red blood corpuscles might interfere withhaemoglobin synthesis and might be one of the factors for renal disease associated anaemia.doi: 10.3329/taj.v16i1.3895TAJ June 2003; Vol.16(1): 12-14

Zinc Intake and Plasma Zinc Level are Maintained in Men Consuming Cholesterol-Lowering Diets

1995 ◽  
Vol 95 (11) ◽  
pp. 1274-1279 ◽  
Author(s):  
BARBARA M RETZLAFF ◽  
CAROLYN E WALDEN ◽  
WILLIAM B McNENEY ◽  
ALICE A DOWDY ◽  
ROBERT H KNOPP
Keyword(s):  
Zinc Level ◽  
Plasma Zinc ◽  
Zinc Intake ◽  
Cholesterol Lowering ◽  
Plasma Zinc Level

Letter to the Editor

PEDIATRICS ◽  
1982 ◽  
Vol 70 (4) ◽  
pp. 661-661
Author(s):  
Andrew W. Zimmerman
Keyword(s):  
Absorptive Capacity ◽  
Zinc Level ◽  
Acrodermatitis Enteropathica ◽  
Zinc Toxicity ◽  
Human Breast Milk ◽  
Plasma Zinc ◽  
Human Breast ◽  
Positive Effect ◽  
Breast Fed ◽  
Plasma Zinc Level

Tasic and colleagues are correct in pointing out the potential hazards of zinc toxicity in treating infants with acrodermatitis due to low zinc in their mothers' milk. Infants, especially premature infants, who have symptoms of acrodermatitis enteropathica while being breast-fed should be assumed to have normal capacity for uptake of zinc in the gut. If breast-feeding is continued during administration of zinc, the plasma zinc level can be expected to rise rapidly. This is due in part to the positive effect of human breast milk on zinc absorption as well as normal absorptive capacity.

scholarly journals Acrodermatitis enteropathica: a case report

2012 ◽  
Vol 10 (2) ◽  
pp. 32-34
Author(s):  
Nabin Bhakta Shakya ◽  
Sudarsan Lal Rajbhandari ◽  
Sagar Mani Jha
Keyword(s):  
Alkaline Phosphatase ◽  
Autosomal Recessive ◽  
Serum Alkaline Phosphatase ◽  
Autosomal Recessive Disorder ◽  
Zinc Level ◽  
Acrodermatitis Enteropathica ◽  
Zinc Status ◽  
Plasma Zinc ◽  
Resistance To Infection ◽  
Plasma Zinc Level

Acrodermatitis enteropathica is rare congenital autosomal recessive disorder. Premature are particularly risk and disease is caused by zinc deficiency due to a specific absorptive defect. This disease manifests in child as peevish, withdrawn and photophobia and develop vesicobullous dermatitis on hands, feet and perioroficial areas and alopecia. Diarrhea is often present. This also presents as shunted growth and decrease resistance to infection. Poor wound healing. A low plasma zinc level and Serum alkaline phosphatase are useful indicator of zinc status. DOI: http://dx.doi.org/10.3126/mjsbh.v10i2.6461 Medical Journal of Shree Birendra Hospital July-Dec 2011 10(2) 32-34

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