scholarly journals Kruppel-like factor 4 regulates neutrophil activation

2017 ◽  
Vol 1 (11) ◽  
pp. 662-668 ◽  
Author(s):  
Yuyan Shen ◽  
Hong Hong ◽  
Panjamaporn Sangwung ◽  
Stephanie Lapping ◽  
Lalitha Nayak ◽  
...  
Keyword(s):  
Crucial Role ◽  
Neutrophil Function ◽  
Neutrophil Activation ◽  
Key Points

Key Points KLF4 deficiency impairs neutrophil function in vitro and in vivo. This is the first demonstration that KLF4 plays a crucial role in neutrophils.

scholarly journals The Effect of Prednisolone on Canine Neutrophil Function: In Vivo and in Vitro Studies

1998 ◽  
Vol 39 (2) ◽  
pp. 201-213
Author(s):  
G. Trowald-Wigh ◽  
L. Håkansson ◽  
A. Johannisson ◽  
L.E. Edqvist
Keyword(s):  
Neutrophil Function ◽  
In Vitro Studies

scholarly journals Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo

2005 ◽  
Vol 146 (3) ◽  
pp. 344-351 ◽  
Author(s):  
Bruce D Levy ◽  
Lorraine Hickey ◽  
Andrew J Morris ◽  
Mykol Larvie ◽  
Raquel Keledjian ◽  
...  
Keyword(s):  
Phospholipase D ◽  
Human Neutrophil ◽  
Neutrophil Activation ◽  
Peritoneal Inflammation

Bmk9 and Uricase Nanoparticle Complex for the Treatment of Gouty Arthritis and Uric Acid Nephropathy

2021 ◽  
Vol 17 (10) ◽  
pp. 2071-2084
Author(s):  
Tianjiao Han ◽  
Meiying Wang ◽  
Wenchao Li ◽  
Mingxing An ◽  
Hongzheng Fu
Keyword(s):  
Uric Acid ◽  
Drug Loading ◽  
Gouty Arthritis ◽  
The Body ◽  
Key Points ◽  
Uric Acid Nephropathy ◽  
Charged Carrier ◽  
Dual Drug

Uric acid is the final product of purine metabolism, and excessive serum uric acid can cause gouty arthritis and uric acid nephropathy. Therefore, lowering the uric acid level and alleviating inflammation in the body are the key points to treating these diseases. A stable nanosuspension of peptide BmK9 was prepared by the precipitation-ultrasonication method. By combining uricase on the surface of a positively charged carrier, a complex consisting of neutral rod-shaped BmK9 and uricase nanoparticles (Nplex) was formed to achieve the delivery of BmK9 and uricase, respectively. The formulation of Nplex has a diameter of 180 nm and drug loading up to 200%, which releases BmK9 and uricase slowly and steadily in drug release tests in vitro. There was significantly improved pharmacokinetic behavior of the two drugs because Nplex prolonged the half-life and increased tissue accumulation. Histological assessments showed that the dual drug Nplex can reduce the inflammation response in acute gouty arthritis and chronic uric acid nephropathy in vivo. In the macrophage system, there was lower toxicity and increased beneficial effect on inflammation with Nplex than free BmK9 or uricase. Collectively, this novel formulation provides a dual drug delivery system that can treat gouty arthritis and uric acid nephropathy.

scholarly journals Therapeutic targeting of HES1 transcriptional programs in T-ALL

Blood ◽  
2015 ◽  
Vol 125 (18) ◽  
pp. 2806-2814 ◽  
Author(s):  
Stephanie A. Schnell ◽  
Alberto Ambesi-Impiombato ◽  
Marta Sanchez-Martin ◽  
Laura Belver ◽  
Luyao Xu ◽  
...  
Keyword(s):  
Therapeutic Targeting ◽  
Key Points

Key Points NOTCH1 inhibits apoptosis via HES1-mediated repression of BBC3 in T-ALL. Perhexiline, a HES1 signature modulator drug, has strong antileukemic effects in vitro and in vivo.

scholarly journals Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets

Blood ◽  
2016 ◽  
Vol 127 (14) ◽  
pp. 1743-1751 ◽  
Author(s):  
Jesse W. Rowley ◽  
Stéphane Chappaz ◽  
Aurélie Corduan ◽  
Mark M. W. Chong ◽  
Robert Campbell ◽  
...  
Keyword(s):  
Functional Responses ◽  
Mirna Processing ◽  
Key Points ◽  
Mrna Profile ◽  
And Function

Key Points Dicer1 deletion in MKs alters platelet miRNA and mRNA profiles. Dicer1-deficient platelets display increased integrins αIIb and β3 levels and enhanced in vitro and in vivo functional responses.

scholarly journals Neutrophil activation in vitro and in vivo in Wegener's granulomatosis

1994 ◽  
Vol 45 (4) ◽  
pp. 1120-1131 ◽  
Author(s):  
Elisabeth Brouwer ◽  
Minke G. Huitema ◽  
A.H. Leontine Mulder ◽  
Peter Heeringa ◽  
Harry van Goor ◽  
...  
Keyword(s):  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Neutrophil Activation

scholarly journals Gene expression–based discovery of atovaquone as a STAT3 inhibitor and anticancer agent

Blood ◽  
2016 ◽  
Vol 128 (14) ◽  
pp. 1845-1853 ◽  
Author(s):  
Michael Xiang ◽  
Haesook Kim ◽  
Vincent T. Ho ◽  
Sarah R. Walker ◽  
Michal Bar-Natan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Retrospective Study ◽  
Human Plasma ◽  
Patient Outcomes ◽  
Anticancer Agent ◽  
Plasma Concentrations ◽  
Anticancer Efficacy ◽  
Key Points

Key PointsThe FDA-approved drug atovaquone is a novel, clinically available inhibitor of STAT3 at standard human plasma concentrations. Atovaquone shows anticancer efficacy in vitro, in vivo, and in a retrospective study of AML patient outcomes after atovaquone treatment.

scholarly journals Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense of Streptococcus pyogenes in vitro and in vivo

2019 ◽  
Vol 10 ◽  
Author(s):  
Anna Hafner ◽  
Ulrike Kolbe ◽  
Isabel Freund ◽  
Virginia Castiglia ◽  
Pavel Kovarik ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Streptococcus Pyogenes ◽  
Crucial Role ◽  
Toll Like Receptors

scholarly journals In vitro and in vivo effects of salbutamol on neutrophil function in acute lung injury

Thorax ◽  
2007 ◽  
Vol 62 (1) ◽  
pp. 36-42 ◽  
Author(s):  
G D Perkins ◽  
N Nathani ◽  
D F McAuley ◽  
F Gao ◽  
D R Thickett
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Neutrophil Function ◽  
In Vivo Effects
Sign in / Sign up

Export Citation Format

Share Document