Primary drug resistance of mycobacterium tuberculosis in HIV-positive patients

2016 ◽  
Author(s):  
Vasily Bondarenko ◽  
Irina Buynevich ◽  
Andrey Holyavkin ◽  
Svetlana Goponyako ◽  
Nkolaj Burinsky
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Hiv Positive ◽  
Primary Drug Resistance ◽  
Primary Drug

Burden of the primary drug resistance of Mycobacterium tuberculosis in HIV-positive patients

2019 ◽  
Author(s):  
Anna Panova ◽  
Vadim Testov ◽  
Grigory Kaminskiy ◽  
Anastasia Samoilova ◽  
Elena Veselova ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Hiv Positive ◽  
Primary Drug Resistance ◽  
Primary Drug

Increase in primary drug resistance of Mycobacterium tuberculosis in younger birth cohorts in France

2012 ◽  
Vol 64 (6) ◽  
pp. 589-595 ◽  
Author(s):  
Vanina Meyssonnier ◽  
Nicolas Veziris ◽  
Sylvaine Bastian ◽  
Jeanne Texier-Maugein ◽  
Vincent Jarlier ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Birth Cohorts ◽  
Primary Drug Resistance ◽  
Primary Drug

scholarly journals The spectrum of primary drug resistance of Mycobacterium tuberculosis in patients with tuberculosis in relation to human immunodeficiency virus status

2017 ◽  
Vol 89 (11) ◽  
pp. 50-54 ◽  
Author(s):  
V N Zimina ◽  
O E Mikova ◽  
T A Varetskaya ◽  
D A Oborin ◽  
S Yu Degtyareva ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Molecular Genetic ◽  
Diagnostic Algorithm ◽  
Human Immunodeficiency Virus Status ◽  
Bacteriological Examination ◽  
Primary Drug Resistance ◽  
Immunodeficiency Virus ◽  
Primary Drug

Aim. To estimate the detection rate and spectrum of primary drug resistance of Mycobacterium tuberculosis (MBT) in patients with tuberculosis (TB) in relation to their human immunodeficiency virus (HIV) status in a region with high HIV infection rates (the Perm Territory) and to compare of drug-resistant MBT (DR-MBT) in patients with HIV/TB co-infection, by using phenotypic and molecular genetic testing (MGT) methods. Subjects and methods. The results of sputum bacteriological examination were analyzed in 178 HIV-infected patients and 354 non-HIV-infected individuals with a TB diagnosis made in the period July 1, 2014 to August 1, 2015. The diagnostic algorithm for all patients involved a duplicate sputum test for MBT by two techniques: fluorescence microscopy (FM) and inoculation into the Levenstein-Jensen dense culture medium. In patients with HIV/TB, the bacteriological examination was complemented with two more methods: detection of MBT DNA by a real-time polymerase chain reaction assay using the AmpliTube-RV system (Synthol, Russia); and inoculation into the Middlebrook liquid nutrient medium, by applying the automated BACTEC MGIT 960 system. Results. In patients with HIV/TB, the sensitivity of FM proved to be lower than in those with TB (24.2 and 32.8%, respectively; p0.05). The primary drug resistance of MBT in patients with HIV-TB was higher than that in HIV-negative individuals (60.2 and 41.6%, respectively; p

scholarly journals The effect of primary drug resistance on CD4+ cell decline and the viral load set-point in HIV-positive individuals before the start of antiretroviral therapy

AIDS ◽  
2019 ◽  
Vol 33 (2) ◽  
pp. 315-326
Author(s):  
Anna Schultze ◽  
Carlo Torti ◽  
Alessandro Cozzi-Lepri ◽  
Anne-Mieke Vandamme ◽  
Maurizio Zazzi ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Viral Load ◽  
Antiretroviral Therapy ◽  
Hiv Positive ◽  
Set Point ◽  
Primary Drug Resistance ◽  
Cell Decline ◽  
Viral Load Set Point ◽  
Cd4 Cell ◽  
Primary Drug

scholarly journals Genetic diversity and primary drug resistance transmission in Mycobacterium tuberculosis in southern Mexico

2021 ◽  
pp. 104994
Author(s):  
Anabel Ordaz-Vázquez ◽  
Pedro Torres-González ◽  
Pablo Cruz-Hervert ◽  
Leticia Ferreyra-Reyes ◽  
Guadalupe Delgado-Sánchez ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Southern Mexico ◽  
Primary Drug Resistance ◽  
Primary Drug

MODELING PRIMARY AND SECONDARY DRUG RESISTANCES UNDER CHINA'S "FOUR-FREE-ONE-CARE POLICY"

2012 ◽  
Vol 05 (05) ◽  
pp. 1250032 ◽  
Author(s):  
JIE LOU ◽  
LINGCHEN BU ◽  
ESTHER HAN ◽  
YUHUA RUAN ◽  
HUI XING ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Latin Hypercube Sampling ◽  
Hiv Infections ◽  
Current Treatment ◽  
Hiv Positive ◽  
Drug Resistant ◽  
Care Policy ◽  
Primary Drug Resistance ◽  
Near Future ◽  
Primary Drug

We propose a mathematical model to evaluate the effect of China's "Four-Free-One-Care Policy" in MSM population in Beijing. We divided the drug resistant HIV patients into two sub-populations: primary drug resistance and secondary drug resistance. Uncertainty and sensitivity analysis based on Latin Hypercube Sampling (LHS) were used for these thresholds of our model. We find that drug-resistant HIV will spread fast in MSM population under China's current treatment policy. Especially, primary-resistant strain is very likely to dominate the HIV positive MSM individuals after 10 years. The conclusions hint that, China's outlook on HIV infections is not optimistic if sufficient kinds free second-line drugs in China cannot be put into use in the near future.

HIV primary drug resistance and associated HIV risk factors among HIV positive blood donors in Brazil from 2007 to 2017

2021 ◽  
Author(s):  
Carlos Henrique Valente Moreira ◽  
Tassila Salomon ◽  
Cecília S. Alencar ◽  
Thelma T. Gonçalez ◽  
Ester C. Sabino ◽  
...  
Keyword(s):  
Risk Factors ◽  
Drug Resistance ◽  
Hiv Risk ◽  
Blood Donors ◽  
Hiv Positive ◽  
Primary Drug Resistance ◽  
Primary Drug ◽  
Hiv Risk Factors
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