scholarly journals The spectrum of primary drug resistance of Mycobacterium tuberculosis in patients with tuberculosis in relation to human immunodeficiency virus status

2017 ◽  
Vol 89 (11) ◽  
pp. 50-54 ◽  
Author(s):  
V N Zimina ◽  
O E Mikova ◽  
T A Varetskaya ◽  
D A Oborin ◽  
S Yu Degtyareva ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Molecular Genetic ◽  
Diagnostic Algorithm ◽  
Human Immunodeficiency Virus Status ◽  
Bacteriological Examination ◽  
Primary Drug Resistance ◽  
Immunodeficiency Virus ◽  
Primary Drug

Aim. To estimate the detection rate and spectrum of primary drug resistance of Mycobacterium tuberculosis (MBT) in patients with tuberculosis (TB) in relation to their human immunodeficiency virus (HIV) status in a region with high HIV infection rates (the Perm Territory) and to compare of drug-resistant MBT (DR-MBT) in patients with HIV/TB co-infection, by using phenotypic and molecular genetic testing (MGT) methods. Subjects and methods. The results of sputum bacteriological examination were analyzed in 178 HIV-infected patients and 354 non-HIV-infected individuals with a TB diagnosis made in the period July 1, 2014 to August 1, 2015. The diagnostic algorithm for all patients involved a duplicate sputum test for MBT by two techniques: fluorescence microscopy (FM) and inoculation into the Levenstein-Jensen dense culture medium. In patients with HIV/TB, the bacteriological examination was complemented with two more methods: detection of MBT DNA by a real-time polymerase chain reaction assay using the AmpliTube-RV system (Synthol, Russia); and inoculation into the Middlebrook liquid nutrient medium, by applying the automated BACTEC MGIT 960 system. Results. In patients with HIV/TB, the sensitivity of FM proved to be lower than in those with TB (24.2 and 32.8%, respectively; p0.05). The primary drug resistance of MBT in patients with HIV-TB was higher than that in HIV-negative individuals (60.2 and 41.6%, respectively; p

Primary drug resistance of mycobacterium tuberculosis in HIV-positive patients

2016 ◽  
Author(s):  
Vasily Bondarenko ◽  
Irina Buynevich ◽  
Andrey Holyavkin ◽  
Svetlana Goponyako ◽  
Nkolaj Burinsky
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Hiv Positive ◽  
Primary Drug Resistance ◽  
Primary Drug

Increase in primary drug resistance of Mycobacterium tuberculosis in younger birth cohorts in France

2012 ◽  
Vol 64 (6) ◽  
pp. 589-595 ◽  
Author(s):  
Vanina Meyssonnier ◽  
Nicolas Veziris ◽  
Sylvaine Bastian ◽  
Jeanne Texier-Maugein ◽  
Vincent Jarlier ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Birth Cohorts ◽  
Primary Drug Resistance ◽  
Primary Drug

Burden of the primary drug resistance of Mycobacterium tuberculosis in HIV-positive patients

2019 ◽  
Author(s):  
Anna Panova ◽  
Vadim Testov ◽  
Grigory Kaminskiy ◽  
Anastasia Samoilova ◽  
Elena Veselova ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Hiv Positive ◽  
Primary Drug Resistance ◽  
Primary Drug

Features of diagnostics of the peripheral lymph nodes tuberculosis

2020 ◽  
Vol 22 (4) ◽  
pp. 43-46
Author(s):  
G. S. Balasaniantc ◽  
V. V. Dantsev ◽  
M. S. Matinina ◽  
B. V. Zarecky ◽  
R. D. Muchaidze
Keyword(s):  
Human Immunodeficiency Virus ◽  
Mycobacterium Tuberculosis ◽  
Lymph Nodes ◽  
Deoxyribonucleic Acid ◽  
Lymphatic System ◽  
Molecular Genetic ◽  
Biopsy Material ◽  
Genetic Studies ◽  
Peripheral Lymph ◽  
Immunodeficiency Virus

The analysis of the features of diagnostics of peripheral lymph nodes tuberculosis in modern conditions is carried out. For this 28 case histories of patients suffering from tuberculosis of peripheral lymph nodes were studied and 85,7% of them had a combination of tuberculosis and infection caused by the human immunodeficiency virus. All patients were undergoing biopsies or surgery of lymph nodes, and the material was examined using microbiological molecular, genetic and histological methods. 85,7% of patients had relapses with different periods of time, on average, 34 years, and repeated periods of tuberculosis activation. At all patients the lymph nodes were enlarged, mainly cervical (71,4%) and axillary (67,9%), the sizes of nodes varied from 1 to 5 cm, on average, 2,21,6 cm. In 78,6% cases tuberculosis of peripheral lymph nodes was characterized by fluctuation of nodes and the discharge of 30 to 80 ml of odorless creamy pus. It was found that tuberculosis of peripheral lymph nodes is part of a widespread tuberculous lesions especially at patients with tuberculosis associated with an infection caused by the human immunodeficiency virus. Tuberculosis of peripheral lymph nodes develops simultaneously with a specific lesion of other groups of lymph nodes intrathoracic (75%), intra-abdominal (57,1%), which allows to generalized tuberculosis of the lymphatic system. Fibrobronchoscopy showed in 35,7% patients residual bronchial tuberculosis changes, at 14,3% an active fistulous form of bronchial tuberculosis. Microscopy of biopsy material was negative at 78,6% of cases, while cultural examination revealed Mycobacterium tuberculosis in 100% and molecular genetic studies deoxyribonucleic acid of Mycobacterium tuberculosis in 64,3% patients.

scholarly journals Genetic diversity and primary drug resistance transmission in Mycobacterium tuberculosis in southern Mexico

2021 ◽  
pp. 104994
Author(s):  
Anabel Ordaz-Vázquez ◽  
Pedro Torres-González ◽  
Pablo Cruz-Hervert ◽  
Leticia Ferreyra-Reyes ◽  
Guadalupe Delgado-Sánchez ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Southern Mexico ◽  
Primary Drug Resistance ◽  
Primary Drug
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