Late Breaking Abstract - Tidal breathing variability during sleep is a sensitive marker of disease control in small children with recurrent wheeze

Author(s):  
Ville-Pekka Seppä ◽  
Marita Paassilta ◽  
Javier Gracia ◽  
Anton Hult ◽  
Jari Viik ◽  
...  
2017 ◽  
Vol 8 ◽  
Author(s):  
Marie-Cécile Niérat ◽  
Bruno-Pierre Dubé ◽  
Claudia Llontop ◽  
Agnès Bellocq ◽  
Lila Layachi Ben Mohamed ◽  
...  

Thorax ◽  
2018 ◽  
Vol 73 (10) ◽  
pp. 936-941 ◽  
Author(s):  
Zihang Lu ◽  
Rachel E Foong ◽  
Krzysztof Kowalik ◽  
Theo J Moraes ◽  
Ayanna Boyce ◽  
...  

BackgroundThe care of infants with recurrent wheezing relies largely on clinical assessment. The lung clearance index (LCI), a measure of ventilation inhomogeneity, is a sensitive marker of early airway disease in children with cystic fibrosis, but its utility has not been explored in infants with recurrent wheezing.ObjectiveTo assess ventilation inhomogeneity using LCI among infants with a history of recurrent wheezing compared with healthy controls.MethodsThis is a case–control study, including 37 infants with recurrent wheezing recruited from outpatient clinics, and 113 healthy infants from a longitudinal birth cohort, the Canadian Healthy Infant Longitudinal Development study. All infants, at a time of clinical stability, underwent functional assessment including multiple breath washout, forced expiratory flows and body plethysmography.ResultsLCI z-score values among infants with recurrent wheeze were 0.84 units (95% CI 0.41 to 1.26) higher than healthy infants (mean (95% CI): 0.26 (−0.11 to 0.63) vs −0.58 (−0.79 to 0.36), p<0.001)). Nineteen percent of recurrently wheezing infants had LCI values that were above the upper limit of normal (>1.64 z-scores). Elevated exhaled nitric oxide, but not symptoms, was associated with abnormal LCI values in infants with recurrent wheeze (p=0.05).ConclusionsVentilation inhomogeneity is present in clinically stable infants with recurrent wheezing.


1975 ◽  
Vol 39 (2) ◽  
pp. 102-105
Author(s):  
Pinkham ◽  
G Ori ◽  
SH Wei ◽  
CA Full ◽  
FM Parkins

2019 ◽  
Vol 28 (3) ◽  
pp. 1363-1370 ◽  
Author(s):  
Jessica Brown ◽  
Katy O'Brien ◽  
Kelly Knollman-Porter ◽  
Tracey Wallace

Purpose The Centers for Disease Control and Prevention (CDC) recently released guidelines for rehabilitation professionals regarding the care of children with mild traumatic brain injury (mTBI). Given that mTBI impacts millions of children each year and can be particularly detrimental to children in middle and high school age groups, access to universal recommendations for management of postinjury symptoms is ideal. Method This viewpoint article examines the CDC guidelines and applies these recommendations directly to speech-language pathology practices. In particular, education, assessment, treatment, team management, and ongoing monitoring are discussed. In addition, suggested timelines regarding implementation of services by speech-language pathologists (SLPs) are provided. Specific focus is placed on adolescents (i.e., middle and high school–age children). Results SLPs are critical members of the rehabilitation team working with children with mTBI and should be involved in education, symptom monitoring, and assessment early in the recovery process. SLPs can also provide unique insight into the cognitive and linguistic challenges of these students and can serve to bridge the gap among rehabilitation and school-based professionals, the adolescent with brain injury, and their parents. Conclusion The guidelines provided by the CDC, along with evidence from the field of speech pathology, can guide SLPs to advocate for involvement in the care of adolescents with mTBI. More research is needed to enhance the evidence base for direct assessment and treatment with this population; however, SLPs can use their extensive knowledge and experience working with individuals with traumatic brain injury as a starting point for post-mTBI care.


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