RAGE blocking ameliorates cigarette smoke extract-induced human alveolar tpye II epithelial cell injury via RAGE-mediated redox sensitive DAMP signaling through Nrf2

2018 ◽  
Author(s):  
Hanbyeol Lee ◽  
Jooyeon Lee ◽  
Se-Ran Yang
Keyword(s):  
Epithelial Cell ◽  
Cigarette Smoke ◽  
Cell Injury ◽  
Cigarette Smoke Extract ◽  
Epithelial Cell Injury

scholarly journals Human Alveolar Epithelial Cell Injury Induced by Cigarette Smoke

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e26059 ◽  
Author(s):  
Beata Kosmider ◽  
Elise M. Messier ◽  
Hong Wei Chu ◽  
Robert J. Mason
Keyword(s):  
Epithelial Cell ◽  
Cigarette Smoke ◽  
Cell Injury ◽  
Alveolar Epithelial Cell ◽  
Alveolar Epithelial ◽  
Human Alveolar Epithelial Cell ◽  
Epithelial Cell Injury

Roles of TRPA1 and TRPV1 in cigarette smoke -induced airway epithelial cell injury model

2019 ◽  
Vol 134 ◽  
pp. 229-238 ◽  
Author(s):  
Muyun Wang ◽  
Yanbei Zhang ◽  
Mengmeng Xu ◽  
Hai Zhang ◽  
Yuqing Chen ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cigarette Smoke ◽  
Cell Injury ◽  
Airway Epithelial Cell ◽  
Airway Epithelial ◽  
Injury Model ◽  
Epithelial Cell Injury

Protective effects of liquiritin apioside on cigarette smoke-induced lung epithelial cell injury

2011 ◽  
Vol 26 (4) ◽  
pp. 473-483 ◽  
Author(s):  
Yan Guan ◽  
Fen-Fen Li ◽  
Ling Hong ◽  
Xiao-Feng Yan ◽  
Gong-Li Tan ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cigarette Smoke ◽  
Cell Injury ◽  
Lung Epithelial Cell ◽  
Protective Effects ◽  
Lung Epithelial ◽  
Epithelial Cell Injury

scholarly journals Cigarette smoke extract and heated tobacco products promote ferritin cleavage and iron accumulation in human corneal epithelial cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wataru Otsu ◽  
Kodai Ishida ◽  
Naoki Chinen ◽  
Shinsuke Nakamura ◽  
Masamitsu Shimazawa ◽  
...  
Keyword(s):  
Cell Death ◽  
T Cell ◽  
Epithelial Cell ◽  
Cigarette Smoke ◽  
Cell Injury ◽  
Cigarette Smoke Extract ◽  
Corneal Epithelial Cell ◽  
Dependent Manner ◽  
Tobacco Products ◽  
Corneal Epithelial

AbstractThe cornea is directly exposed to cigarette smoke, and smoking is a risk factor for several corneal diseases including dry eye syndrome. Currently, heated tobacco products (HTPs) are widely used as substitutes for cigarette smoking around the world. In the present study, we investigated the molecular mechanism(s) leading to cellular injury induced by cigarette smoke extract (CSE) or HTPs. Exposure to CSE perturbed the formation of tight junctions, leading to an increase in cell volume, a decrease in transepithelial electrical resistance (TER) in the human corneal epithelial cell-transformed (HCE-T) cell line. Moreover, CSE exposure induced both lipid peroxidation and ferrous [Fe(II)] ion accumulation in autolysosomal compartments. Interestingly, a cleaved form of ferritin appeared when HCE-T cells were incubated with CSE. This aberrant ferritin processing was suppressed by treatment with autophagy inhibitors. Furthermore, the CSE-induced cell death was suppressed by either ferrostatin-1 or deferoxamine (DFO). CSE exposure also promoted the expression of cytokines whereas DFO treatment inhibited the CSE-induced expression of these cytokines. Exposure to HTPs also induced both HCE-T cell death and cleaved ferritin accumulation in a concentration- and time-dependent manner. These results indicated that CSE or HTPs activated the ferroptosis signaling pathway, which contributed to corneal epithelial cell injury.

Nix/BNIP3L‐dependent mitophagy accounts for airway epithelial cell injury induced by cigarette smoke

2019 ◽  
Vol 234 (8) ◽  
pp. 14210-14220 ◽  
Author(s):  
Ming Zhang ◽  
Rong Shi ◽  
Yeli Zhang ◽  
Hu Shan ◽  
Qiuhong Zhang ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cigarette Smoke ◽  
Cell Injury ◽  
Airway Epithelial Cell ◽  
Airway Epithelial ◽  
Epithelial Cell Injury

Cigarette smoke augments asbestos-induced alveolar epithelial cell injury: role of free radicals

1998 ◽  
Vol 25 (6) ◽  
pp. 728-739 ◽  
Author(s):  
David W. Kamp ◽  
Marc J. Greenberger ◽  
Jane S. Sbalchierro ◽  
Scott E. Preusen ◽  
Sigmund A. Weitzman
Keyword(s):  
Free Radicals ◽  
Epithelial Cell ◽  
Cigarette Smoke ◽  
Cell Injury ◽  
Alveolar Epithelial Cell ◽  
Alveolar Epithelial ◽  
Epithelial Cell Injury
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