The role of hyaluronan metabolism in obstructive sleep apnoea

Author(s):  
Martina Meszaros ◽  
Zsofia Lazar ◽  
Adam Domonkos Tarnoki ◽  
David Laszlo Tarnoki ◽  
Adrian Kis ◽  
...  
BDJ ◽  
2020 ◽  
Vol 228 (9) ◽  
pp. 681-685
Author(s):  
Minnie Lyons-Coleman ◽  
Claire Bates ◽  
Sophy Barber

2020 ◽  
Vol 9 (2) ◽  
pp. 546 ◽  
Author(s):  
Tomas Posadas ◽  
Grace Oscullo ◽  
Enrique Zaldívar ◽  
Alberto Garcia-Ortega ◽  
José Daniel Gómez-Olivas ◽  
...  

The population pyramid is changing as a result of the ever-increasing life expectancy, which makes it crucial to acquire an in-depth understanding of the diseases that most often affect the elderly. Obstructive sleep apnoea (OSA) affects 15%–20% of the population aged over 65 years. Despite this prevalence, there have been very few specific studies on the management of OSA in this age group, even though over 60% of the patients aged over 65-70 years who attend sleep units with suspicion of OSA receive treatment with continuous positive airway pressure (CPAP), on the basis of an extrapolation of the positive results achieved by CPAP in clinical trials involving middle-aged males. However, the latter’s form of presentation, evolution and, probably, prognosis comparing with OSA are not the same as those of elderly patients. Recent clinical trials performed on an exclusive series of elderly patients have shed light on the possible role of CPAP treatment in elderly patients with OSA, but there are still many questions that need to be answered. The physiological increase in the number of sleep-related disorders with the passing of years, and the lack of validated diagnostic and therapeutic tools for this age group are probably the greatest obstacles to define, diagnose and treat OSA in the elderly.


Thorax ◽  
1995 ◽  
Vol 50 (1) ◽  
pp. 28-34 ◽  
Author(s):  
S Okabe ◽  
W Hida ◽  
Y Kikuchi ◽  
O Taguchi ◽  
H Ogawa ◽  
...  

Author(s):  
Andras Bikov ◽  
Martina Meszaros ◽  
Peter Horvath ◽  
Zsofia Lazar ◽  
David Tarnoki ◽  
...  

2008 ◽  
Vol 60 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Bhawna ◽  
Roy Santosham ◽  
Sujai Anand ◽  
Santhosh Joseph

2019 ◽  
Vol 53 (2) ◽  
pp. 1800893 ◽  
Author(s):  
Alberto García-Ortega ◽  
Eva Mañas ◽  
Raquel López-Reyes ◽  
María José Selma ◽  
Aldara García-Sánchez ◽  
...  

Obstructive sleep apnoea (OSA) and pulmonary embolism (PE) remain major health issues worldwide. Data from pathophysiological studies suggest that both intermittent hypoxia and sleep fragmentation are associated with increased blood coagulability, endothelial dysfunction and venous stasis. There is growing evidence that OSA is potentially prevalent in and a risk factor for PE. Conversely, patients with acute PE have two to four times greater risk of moderate-to-severe OSA. The role of continuous positive airway pressure (CPAP) treatment in improving clinically meaningful outcomes in PE patients remains unclear, although some authors have suggested that CPAP could improve the hypercoagulability state and normalise circadian alterations in some of the coagulation molecules, as observed in patients with OSA. Emerging research highlights the complex interdependent relationships between OSA and PE, emphasising the need for rigorous, well-powered trials that address the impact of OSA and its treatment on the prevention and management of PE. Undoubtedly, these will require closer collaboration between the sleep medicine and clinical/venous thromboembolism communities.


2007 ◽  
Vol 30 (6) ◽  
pp. 1208-1215 ◽  
Author(s):  
M. Kohler ◽  
K. E. Bloch ◽  
J. R. Stradling

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