Impaired response to 13-valent pneumococcal conjugate vaccine (PCV13) in children with recurrent respiratory infections and chronic cough

Tracheal diverticulum is defined as an air cyst located on the lateral wall, congenital or acquired. Most of them are asymptomatic, incidentally found on CT. The common symptoms are chronic cough, stridor, or recurrent respiratory infections. Asymptomatic diverticulum requires no treatment and managed conservatively while surgical excision is indicated in cases of local complications or symptom permanence. We report a case of tracheal diverticulum presented with haemoptysis, a rare symptom. The diagnosis was made with a CT that shows a 15 mm air image on the right lateral trachea wall. Due to symptoms’ persistence, we decide to perform surgery with a good outcome.

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Acute Lower Respiratory Infections Among Indigenous Children in the Northern Territory of Australia: A Decade of Observation Spanning Three Generations of Pneumococcal Conjugate Vaccine

SSRN Electronic Journal ◽

10.2139/ssrn.3487788 ◽

2019 ◽

Author(s):

Michael Binks ◽

Jemima Beissbarth ◽

Victor M. Oguoma ◽

Susan J. Pizzutto ◽

Amanda J. Leach ◽

...

Keyword(s):

Conjugate Vaccine ◽

Pneumococcal Conjugate Vaccine ◽

Respiratory Infections ◽

Northern Territory ◽

Three Generations ◽

Acute Lower Respiratory Infections ◽

Indigenous Children

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Serum Vitamin D Levels in Children with Recurrent Respiratory Infections and Chronic Cough

The Indian Journal of Pediatrics ◽

10.1007/s12098-015-2010-1 ◽

2016 ◽

Vol 83 (8) ◽

pp. 777-782 ◽

Cited By ~ 2

Author(s):

Beril Özdemir ◽

Burcu Tahire Köksal ◽

Nazmi Mutlu Karakaş ◽

Mustafa Agah Tekindal ◽

Özlem Yılmaz Özbek

Keyword(s):

Vitamin D ◽

Chronic Cough ◽

Respiratory Infections ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Recurrent Respiratory Infections ◽

Vitamin D Levels

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Noninvasive Streptococcus pneumoniae Serotypes Recovered from Hospitalized Adult Patients in the United States in 2009 to 2012

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00182-15 ◽

2015 ◽

Vol 59 (9) ◽

pp. 5595-5601 ◽

Cited By ~ 17

Author(s):

Rodrigo E. Mendes ◽

Rosalind C. Hollingsworth ◽

Andrew Costello ◽

Ronald N. Jones ◽

Raul E. Isturiz ◽

...

Keyword(s):

United States ◽

Streptococcus Pneumoniae ◽

Conjugate Vaccine ◽

Pneumococcal Conjugate Vaccine ◽

Respiratory Infections ◽

Adult Population ◽

The United States ◽

Adult Patients ◽

Content Type ◽

Trends Over Time

ABSTRACTThis study was conducted to determine the serotype distribution and trends over time ofStreptococcus pneumoniaestrains associated with noninvasive infections among adult patients ≥18 years of age in the United States (2009 to 2012). A total of 2,927S. pneumoniaeisolates recovered from patients presenting with respiratory infections and obtained mainly (87.0%) from lower respiratory tract specimens (sputum) were included. The levels of the 7-valent pneumococcal conjugate vaccine (PCV7) serotypes remained stable over the 4-year study period (4.6% to 5.5%;P= 0.953). Overall, 13-valent pneumococcal conjugate vaccine (PCV13) serotypes were identified in 32.7% of samples, declining from 33.7% to 35.5% in 2009 to 2011 to 28.2% in 2012 (P= 0.007), with a significant decrease in the levels of serotypes 7F (P= 0.013) and 6A (P= 0.010). The levels of 19A remained constant (15.8% to 17.1%) during 2009 to 2011, dropping to 12.2% in 2012 (P= 0.089). The prevalence of serotypes associated with the 23-valent pneumococcal polysaccharide vaccine (PPSV23), but not PCV13, remained generally stable; however, the prevalence of serotypes 15B and 15C (15B/15C) increased from 2.7% to 6.3% (P= 0.010). The proportion of nonvaccine serotypes increased gradually during the study period (P= 0.044), particularly for serotype 35B (from 3.6% in 2009 to 8.2% in 2012;P= 0.001). Nonsusceptibility rates for penicillin (susceptible breakpoint, ≤2 μg/ml) and clindamycin against PCV7 serotypes decreased over the period. These results suggest the emergence of indirect effects following introduction of PCV13 for infants and young children; continued surveillance is needed to assess the burden of PCV13 serotypes in the adult population after the implementation of age-based recommendations in the United States.

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Serum Vitamin D Levels in Children with Recurrent Respiratory Infections and Chronic Cough: Correspondence

The Indian Journal of Pediatrics ◽

10.1007/s12098-016-2224-x ◽

2016 ◽

Vol 84 (2) ◽

pp. 172-173 ◽

Cited By ~ 1

Author(s):

Anirban Mandal ◽

Puneet Kaur Sahi

Keyword(s):

Vitamin D ◽

Chronic Cough ◽

Respiratory Infections ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Recurrent Respiratory Infections ◽

Vitamin D Levels

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Tracheal diverticulum: an unusual cause of chronic cough and recurrent respiratory infections

Tuberkuloz ve Toraks ◽

10.5578/tt.9700 ◽

2016 ◽

Vol 64 (1) ◽

pp. 77-82

Author(s):

Rajendra Prasad TAKHAR ◽

Motilal BUNKAR ◽

Shubhra JAIN ◽

Sanjay GHABALE

Keyword(s):

Chronic Cough ◽

Respiratory Infections ◽

Recurrent Respiratory Infections ◽

Tracheal Diverticulum

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Experience of Vaccination of a Patient with Systemic Juvenile Idiopathic Arthritis (sJIA) with a 13-Valent Pneumococcal Conjugate Vaccine, prior to the Appointment of Therapy with Tocilizumab, an Anti-IL-6-Receptor Monoclonal Antibody

Вопросы современной педиатрии ◽

10.15690/vsp.v17i4.1926 ◽

2018 ◽

Vol 17 (4) ◽

pp. 322-327 ◽

Cited By ~ 1

Author(s):

Daria D. Vankova ◽

Ekaterina I. Alekseeva ◽

Margarita А. Soloshenko ◽

Tatiana М. Dvoriakovskaia ◽

Ksenia B. Isaeva ◽

...

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Conjugate Vaccine ◽

Rheumatic Diseases ◽

Pneumococcal Conjugate Vaccine ◽

Respiratory Infections ◽

Systemic Juvenile Idiopathic Arthritis ◽

Genetically Engineered ◽

Antibacterial Drugs ◽

Systemic Jia ◽

First Choice

Background. Infections are the main cause of death for patients with autoimmune rheumatic diseases. In adult patients with rheumatoid arthritis (RA), mortality caused by respiratory infections is 2–5 times higher than in the population. One of the frequent infectious complications in the course of treatment with tocilizumab, the first-choice drug for treating systemic juvenile idiopathic arthritis (sJIA), is pneumonia characterized by a poor clinical picture, normal values of laboratory indices of the disease activity (ESR, C-reactive protein) with pronounced changes in the lungs revealed by computed tomography. In case of acute respiratory infection in children with systemic JIA, immunosuppressants and genetically engineered biological preparations (GEBP) are discontinued. This often leads to an exacerbation of the underlying disease and the progression of a pathological process. At present, vaccination against pneumococcal infection in Russia is not included in the standard for managing patients with rheumatic diseases. Studies of the safety and efficacy of vaccination with 13-valent pneumococcal conjugate vaccine (PCV) in patients with sJIA receiving genetically engineered biological preparations were not conducted. Clinical Case Description. The article shares the experience of vaccination of a girl aged 9 years with a 13-valent PCV that was conducted in the course of a scientific investigation, which studied the efficacy and safety of vaccination of children with systemic JIA prior to prescription of GEBP tocilizumab. Vaccination did not cause a deterioration in the course of the main disease (1 month), led to a reduction in the incidence of acute respiratory infections (from 4 to 1 time within 6 months before and after vaccination), and discontinuation of antibacterial drugs within 6 months after vaccination. Conclusion. The safety of a 13-valent PCV in a child with sJIA and a decrease of the incidence of respiratory diseases after vaccination, their complications, and the use of antibacterial drugs have been shown.

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