Screening for major depression in the workplace: testing diagnostic accuracy of a two-item questionnaire used during mandatory testing

2006 ◽  
Vol 11 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Takeaki Takeuchi ◽  
Mutsuhiro Nakao ◽  
Eiji Yano
BMJ Open ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. e026598 ◽  
Author(s):  
Andrea Benedetti ◽  
Yin Wu ◽  
Brooke Levis ◽  
Machelle Wilchesky ◽  
Jill Boruff ◽  
...  

IntroductionThe 30-item Geriatric Depression Scale (GDS-30) and the shorter GDS-15, GDS-5 and GDS-4 are recommended as depression screening tools for elderly individuals. Existing meta-analyses on the diagnostic accuracy of the GDS have not been able to conduct subgroup analyses, have included patients already identified as depressed who would not be screened in practice and have not accounted for possible bias due to selective reporting of results from only better-performing cut-offs in primary studies. Individual participant data meta-analysis (IPDMA), which involves a standard systematic review, then a synthesis of individual participant data, rather than summary results, could address these limitations. The objective of our IPDMA is to generate accuracy estimates to detect major depression for all possible cut-offs of each version of the GDS among studies using different reference standards, separately and among participant subgroups based on age, sex, dementia diagnosis and care settings. In addition, we will use a modelling approach to generate individual participant probabilities for major depression based on GDS scores (rather than a dichotomous cut-off) and participant characteristics (eg, sex, age, dementia status, care setting).Methods and analysisIndividual participant data comparing GDS scores to a major depression diagnosis based on a validated structured or semistructured diagnostic interview will be sought via a systematic review. Data sources will include Medline, Medline In-Process & Other Non-Indexed Citations, PsycINFO and Web of Science. Bivariate random-effects models will be used to estimate diagnostic accuracy parameters for each cut-off of the different versions of the GDS. Prespecified subgroup analyses will be conducted. Risk of bias will be assessed with the Quality Assessment of Diagnostic Accuracy Studies-2 tool.Ethics and disseminationThe findings of this study will be of interest to stakeholders involved in research, clinical practice and policy.PROSPERO registration numberCRD42018104329.


2015 ◽  
Vol 5 (9) ◽  
Author(s):  
Anja Fischer ◽  
Marcus Fischer ◽  
Robert A. Nicholls ◽  
Stephanie Lau ◽  
Jana Poettgen ◽  
...  

Pain ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
C Roldán-Majewski ◽  
E Broedel ◽  
M von Korff ◽  
P Rammelsberg ◽  
HJ Schindler ◽  
...  

2004 ◽  
Vol 95 (3_suppl) ◽  
pp. 1241-1247 ◽  
Author(s):  
Grant L. Iverson ◽  
Ronald Remick

The purpose of this study was to examine the diagnostic accuracy and clinical usefulness of the British Columbia Major Depression Inventory. Participants were 62 patients with depression referred by their psychiatrist or family physician, 19 general medical outpatients with no psychiatric problems referred by their family physicians, and 49 community control subjects. Mean age for the control subjects was 50.2 yr. ( SD = 11.8), and mean education was 14.6 yr. ( SD = 2.8). Approximately 59% were women. Mean age for the patients with depression was 41.1 yr. ( SD = 12.5), and mean education was 14.6 yr. ( SD = 3.2). Approximately 71% were women. Scores of 9 or less are considered broadly normal. Applying this cut-off, the sensitivity of the test to detect depression was .92, and the specificity was .99. Thus, the test did not identify approximately 8% of the cases of depression, with 1.5% false positives. This inventory is a relatively new depression screening test patterned after the DSM–IV criteria for major depression. This study adds to a growing literature on the reliability, validity, and clinical usefulness of the test.


2019 ◽  
Vol 50 (8) ◽  
pp. 1368-1380 ◽  
Author(s):  
Yin Wu ◽  
Brooke Levis ◽  
Kira E. Riehm ◽  
Nazanin Saadat ◽  
Alexander W. Levis ◽  
...  

AbstractBackgroundItem 9 of the Patient Health Questionnaire-9 (PHQ-9) queries about thoughts of death and self-harm, but not suicidality. Although it is sometimes used to assess suicide risk, most positive responses are not associated with suicidality. The PHQ-8, which omits Item 9, is thus increasingly used in research. We assessed equivalency of total score correlations and the diagnostic accuracy to detect major depression of the PHQ-8 and PHQ-9.MethodsWe conducted an individual patient data meta-analysis. We fit bivariate random-effects models to assess diagnostic accuracy.Results16 742 participants (2097 major depression cases) from 54 studies were included. The correlation between PHQ-8 and PHQ-9 scores was 0.996 (95% confidence interval 0.996 to 0.996). The standard cutoff score of 10 for the PHQ-9 maximized sensitivity + specificity for the PHQ-8 among studies that used a semi-structured diagnostic interview reference standard (N = 27). At cutoff 10, the PHQ-8 was less sensitive by 0.02 (−0.06 to 0.00) and more specific by 0.01 (0.00 to 0.01) among those studies (N = 27), with similar results for studies that used other types of interviews (N = 27). For all 54 primary studies combined, across all cutoffs, the PHQ-8 was less sensitive than the PHQ-9 by 0.00 to 0.05 (0.03 at cutoff 10), and specificity was within 0.01 for all cutoffs (0.00 to 0.01).ConclusionsPHQ-8 and PHQ-9 total scores were similar. Sensitivity may be minimally reduced with the PHQ-8, but specificity is similar.


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